The Frequency of Autoimmune Thyroid Disease in Alopecia Areata and Vitiligo Patients

Kurtipek, Gülcan Saylam; Ci̇han, Fatma Gökşin; Demirbaş, Şule Erayman; Ataseven, Arzu

doi:10.1155/2015/435947

Cited by 29 publications

(33 citation statements)

References 19 publications

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“…However, Gulcan Saylam Kurtipek, et al, found high levels of anti-TPO in 16 (14.8%) and anti-TG in 9 (8.3%) out of 108 vitiligo patients, these rates are lower than our study [16]. In addition, previous studies reported a significantly increased prevalence of vitiligo in patients with autoimmune thyroid disease compared to patients with non-autoimmune thyroid disease [10,16].…”

Section: Discussioncontrasting

confidence: 74%

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Thyroid Dysfunction in Libyan Vitiligo Patients

SA¹,

Na²

2017

IJCDR

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Background: Vitiligo is an acquired depigmenting disorder due to destruction of melanocytes, many hypotheses have been suggested for its pathogenesis. One of these hypotheses suggest that there are autoimmune and endocrine dysfunction involvement. The involvement of vitiligo with thyroid autoimmune diseases, with the increased prevalence of auto antibodies including thyroid auto antibodies in vitiligo support the hypothesis. Patients and Methods: 50 Libyan patients under same age and gender with vitiligo, and 50 controls . Patients were excluded if they had a history of thyroid, or other autoimmune diseases. Data on age, onset of illness, duration and disease activity were determined . Serum T3, T4, TSH , and antibodies to TPO and TG were measured in both vitiligo patients & controls. All patients and control subjects underwent thyroid ultrasonography. Results: Fifty patients with vitiligo and their 50 matched controls were studied. More than half of the patients (52%) were females and 48% were males, their mean of age was 40 ± 11 years, and the duration of vitiligo was 11± 9 years. Vitiligo vulgaris type was the most common form seen in 68% of the patients, and 42% reported at least one family member affected with vitiligo. Family history of thyroid disorder was seen in 20% of the patients. Thyroid functional abnormalities were significantly seen more in patients than control subjects. The frequency of TG and TPO thyroid autoantibodies was significantly higher in vitiligo patients than in healthy controls (P < 0.01). Abnormal thyroid ultrasound study was seen in 18 (36%) of the patients compared to 6 (12%) of the control subjects (P < 0.05). Conclusion: Our findings pointed to a significant association between vitiligo and thyroid autoimmunity and showed that testing the level of thyroid autoantibodies is relevant in vitiligo patients.

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Section: Discussioncontrasting

confidence: 74%

“…In addition, previous studies reported a significantly increased prevalence of vitiligo in patients with autoimmune thyroid disease compared to patients with non-autoimmune thyroid disease [10,16].…”

Section: Discussionmentioning

confidence: 93%

Thyroid Dysfunction in Libyan Vitiligo Patients

SA¹,

Na²

2017

IJCDR

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“…Furthermore, results vary among studies. Positive thyroglobulin antibodies were found in 22–46% of patients with AA and positive thyroid peroxidase antibodies were found in 9–48% of patients with AA . Abnormal thyroid function tests were found in 8.9–27% of patients with AA .…”

Section: Discussionmentioning

confidence: 96%

Alopecia areata and overt thyroid diseases: A nationwide population‐based study

Han

Lee

Noh

et al. 2018

The Journal of Dermatology

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An association between alopecia areata (AA) and other autoimmune diseases has been reported. We investigated the associations between AA and overt autoimmune thyroid diseases. A nationwide, population-based, cross-sectional study was performed using the Korea National Health Insurance claims database. We defined patients with AA as those whose records showed at least four physician contacts in which AA, alopecia totalis (AT) or alopecia universalis (AU) was the principal diagnosis. We also established an age- and sex-matched control group without AA. In a subgroup analysis, patients with AT or AU were classified into the severe AA group, and the remainder were classified into the mild to moderate AA group. Patients with AA were at an increased risk of Graves' disease (odds ratio [OR], 1.415; 95% confidence interval [CI], 1.317-1.520) and Hashimoto thyroiditis (OR, 1.157; 95% CI, 1.081-1.237), and the associations were stronger in the severe AA group (Graves' disease: OR, 1.714; 95% CI, 1.387-2.118; Hashimoto thyroiditis: OR, 1.398; 95% CI, 1.137-1.719). In conclusion, AA was significantly associated with overt autoimmune thyroid diseases. Furthermore, the risk was much higher in the severe AA group.

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“…Several other studies document higher frequencies of AITD in women . Conversely, another study found the association between overt thyroid disease and vitiligo to be stronger in males compared to females, while others found no association between gender and AITD or between gender and anti‐TPO levels …”

Section: Specific Autoimmune Comorbiditiesmentioning

confidence: 95%

“…Alopecia areata is an autoimmune disease that is characterized by patchy or total hair loss of the scalp hair and sometimes universal loss of all body hair . A sizable proportion of vitiligo patients have simultaneous alopecia areata.…”

Section: Specific Autoimmune Comorbiditiesmentioning

confidence: 99%

Comorbidities in vitiligo: comprehensive review

2018

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Vitiligo is a common skin disorder characterized by idiopathic, progressive cutaneous hypomelanosis. Vitiligo is associated with several comorbid autoimmune, systemic, and dermatological diseases, primarily thyroid disease, alopecia areata, diabetes mellitus, pernicious anemia, systemic lupus erythematosus, rheumatoid arthritis, Addison's disease, inflammatory bowel disease, Sjögren's syndrome, dermatomyositis, scleroderma, ocular and audiological abnormalities, psoriasis, and atopic dermatitis. It is essential to increase awareness of these comorbidities in order to improve the disease burden and quality of life of patients with vitiligo. Herein, we review the association with the most frequent comorbidities associated with vitiligo.

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The Frequency of Autoimmune Thyroid Disease in Alopecia Areata and Vitiligo Patients

Cited by 29 publications

References 19 publications

Thyroid Dysfunction in Libyan Vitiligo Patients

Thyroid Dysfunction in Libyan Vitiligo Patients

Alopecia areata and overt thyroid diseases: A nationwide population‐based study

Comorbidities in vitiligo: comprehensive review

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