The frequency of bladder cancer in Alexandria, Egypt, over the last two decades

Sayed, El; Elkhwsky, Fayek; Vecchia, Carlo La; Alicandro, Gianfranco

doi:10.1097/cej.0000000000000368

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…The eradication programs of schistosomiasis, through praziquantel mass drug administration and sanitation measures implemented in the selected Northern African countries over the last decades, explain the declining trends observed for bladder cancer ( Adeloye et al ., 2019 ; Parkin et al , 2020 ). The male-to-female ratio (M: F) was in the Southern African countries in line with that observed in Europe (around 4 : 1); the wider gender gap seen in Northern African countries (up to 8 : 1 in Morocco) reflects the strong gender disparities in smoking consumption and possibly occupational exposure to aromatic amines ( Felix et al ., 2008 ; El Sayed et al , 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Cancer mortality patterns in selected Northern and Southern African countries

Pizzato,

Santucci,

Parazzini

et al. 2023

European Journal of Cancer Prevention

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Background Non-communicable diseases have been rapidly increasing in African countries. We provided updated cancer death patterns in selected African countries over the last two decades. Methods We extracted official death certifications and population data from the WHO and the United Nations Population Division databases. We computed country- and sex-specific age-standardized mortality rates per 100 000 person-years for all cancers combined and ten major cancer sites for the periods 2005–2007 and 2015–2017. Results Lung cancer ranked first for male cancer mortality in all selected countries in the last available period (with the highest rates in Réunion 24/100 000), except for South Africa where prostate cancer was the leading cause of death (23/100 000). Prostate cancer ranked second in Morocco and Tunisia and third in Mauritius and Réunion. Among Egyptian men, leukemia ranked second (with a stable rate of 4.2/100 000) and bladder cancer third (3.5/100 000). Among women, the leading cancer-related cause of death was breast cancer in all selected countries (with the highest rates in Mauritius 19.6/100 000 in 2015–2017), except for South Africa where uterus cancer ranked first (17/100 000). In the second rank there were colorectal cancer in Tunisia (2/100 000), Réunion (9/100 000) and Mauritius (8/100 000), and leukemia in Egypt (3.2/100 000). Colorectal and pancreas cancer mortality rates increased, while stomach cancer mortality rates declined. Conclusion Certified cancer mortality rates are low on a global scale. However, mortality rates from selected screening detectable cancers, as well as from infection-related cancers, are comparatively high, calling for improvements in prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Cancer mortality patterns in selected Northern and Southern African countries

Pizzato,

Santucci,

Parazzini

et al. 2023

European Journal of Cancer Prevention

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“…Others suggested that soluble antigens of Schistosoma itself are the direct cause of genotoxicity, aided by chronic inflammation [ 30 ]. SIBC incidence is in decline owing to schistosomiasis infection control [ 31 ].…”

Section: What Causes Dna Genomic Alterations In Uc?mentioning

confidence: 99%

Molecular Basis of Tumorigenesis of Bladder Cancer and Emerging Concepts in Developing Therapeutic Targets

Abdeltwab,

Yacoub,

Rashad

et al. 2023

Bladder Cancer

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BACKGROUND: Advanced urothelial carcinoma (UC) is an aggressive disease whose mutagenic processes are yet to be elucidated. Targeted therapies are urgently needed, but the road from bench to bedside is slowly progressing. In this review, we discuss urothelial carcinoma etiology, along with the most recent advances in UC candidate targeted therapies. METHODOLOGY: A comprehensive database search was performed. We aimed to review the most recent updates on UC genomics and targeted therapies. Pre-clinical as well as clinical studies were included. RESULTS: Our review highlights the advances in understanding the molecular basis of urothelial tumorigenesis, including smoking, chemical parasitic carcinogens, inheritance, and APOBEC3 editing enzymes. We discussed how these factors contributed to the current mutational landscape of UC. Therapeutic options for UC are still very limited. However, several promising therapeutic approaches are in development to leverage our knowledge of molecular targets, such as targeting fibroblast growth factor receptors (FGFR), DNA damage repair pathways, and HER2. CONCLUSIONS: Blindly testing targeted therapies based on other cancer data is not sufficient. UC-specific biomarkers are needed to precisely use the appropriate drug for the appropriate population. More efforts to understand UC biology and evolution are urgently needed.

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Piceatannol inhibits proliferation and induces apoptosis of bladder cancer cells through regulation of the PTEN/AKT signal pathway

Li¹,

Zhang²,

Yan³

2020

Cell Mol Biol (Noisy-le-grand)

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This study was aimed to investigate the effect of piceatannol (PIC) on the proliferation and apoptosis of bladder cancer cell line EJ, and the underlying mechanism. Bladder cancer cell line EJ was incubated with different concentrations of PIC, and CCK-8 method was used to determine the effect of the treatment on cell proliferation. The effect of PIC on cell cycle, apoptosis and the expressions of related signal pathway proteins were determined using Western blotting. Flow cytometry showed that PIC inhibited the proliferation of EJ cells in a concentration- and time-dependent fashion. Moreover, EJ cells were significantly blocked in G0/G1 phase, when compared with the blank control group (p < 0.05). In addition, PIC enhanced apoptosis of EJ cells in a concentration-dependent manner (p < 0.05). Results from western blotting showed that, compared with the control group, PIC upregulated the protein expression of PTEN, but downregulated Akt protein phosphorylation, relative to control cells. PIC significantly inhibits the proliferation of EJ cells and enhances their apoptosis through a mechanism related to the activation of PTEN/Akt signaling pathway.

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The frequency of bladder cancer in Alexandria, Egypt, over the last two decades

Cited by 3 publications

References 9 publications

Cancer mortality patterns in selected Northern and Southern African countries

Cancer mortality patterns in selected Northern and Southern African countries

Molecular Basis of Tumorigenesis of Bladder Cancer and Emerging Concepts in Developing Therapeutic Targets

Piceatannol inhibits proliferation and induces apoptosis of bladder cancer cells through regulation of the PTEN/AKT signal pathway

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