The Frequency of Tumor-infiltrating Tie–2-expressing Monocytes in Renal Cell Carcinoma: Its Relationship to Angiogenesis and Progression

Ji, Jindong; Zhang, Guangbo; Sun, Bo; Yuan, Huipin; Huang, Yuhua; Zhang, Jianglei; Wei, Xuedong; Zhang, Xuefeng; Hou, Jianquan

doi:10.1016/j.urology.2013.05.026

Cited by 21 publications

(16 citation statements)

References 25 publications

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“… 21 Our preliminary study also showed that in renal cancer, a significant increase in the frequency of TEMs among infiltrating mononuclear cells occurs with tumor progression and angiogenesis, which was positively correlated with MVD. 22 The results of the present study demonstrated that Tie-2 is highly expressed in the vascular endothelium of ccRCC and that its expression is related to tumor staging and lymph node metastasis. These results indicate that Tie-2 is involved in ccRCC angiogenesis and is associated with invasion and metastasis in ccRCC patients.…”

Section: Discussionsupporting

confidence: 53%

Expression and significance of B7-H3 and Tie-2 in the tumor vasculature of clear cell renal carcinoma

Zhang

et al. 2017

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Tumor angiogenesis is required for tumor growth and metastasis, and the Ang/Tie-2 axis plays a pivotal role in angiogenesis. B7-H3, a new member of the B7 family of costimulatory molecules, has a critical function in the T-cell-mediated antitumor immune response, and abnormal tumor B7-H3 expression is frequently associated with a poor prognosis. However, the relationship between B7-H3 and angiogenesis in clear cell renal carcinoma (ccRCC) remains unclear. In this study, we used immunohistochemical methods to detect tumor vascular expression of B7-H3 and Tie-2 in tissue microarrays of 82 ccRCC patient samples. According to the results, B7-H3 is highly expressed in the tumor vascular endothelium of ccRCC and is associated with the ccRCC grade and tumor-node-metastasis (TNM) stage. Although vascular Tie-2 expression was also correlated with T stage and lymph node metastasis, it was not related to ccRCC grade or distant metastasis. The microvessel density (MVD) labeled by CD34 was correlated with tumor grade and TNM stage. Expression of B7-H3 and Tie-2 was positively correlated, and the levels were positively associated with the MVD. Additionally, immunofluorescence staining revealed coexpression of B7-H3 and Tie-2 in the vascular endothelia of ccRCC. Collectively, our findings suggest that expression of B7-H3 and Tie-2 in ccRCC tumor vasculature is closely related to the progression and prognosis of the disease. Furthermore, B7-H3 possibly promotes ccRCC angiogenesis through the Tie-2 pathway. Thus, B7-H3 might serve as an effective endothelial marker for ccRCC prognosis and become a promising target for ccRCC anti-angiogenic-targeted therapy.

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Section: Discussionsupporting

confidence: 53%

Expression and significance of B7-H3 and Tie-2 in the tumor vasculature of clear cell renal carcinoma

Zhang

et al. 2017

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“…Finally, these TIE2 + PV TAMs may also have a proangiogenic role in human cancers as their frequency has been reported to correlate with the density of tumor microvessels, as well as lymph node status, tumor grade, and distant metastasis (Ji et al, 2013; Matsubara et al, 2013). …”

Section: Tumor Angiogenesismentioning

confidence: 98%

The Multifaceted Role of Perivascular Macrophages in Tumors

2016

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Evidence has emerged for macrophages in the perivascular niche of tumors regulating important processes like angiogenesis, various steps in the metastatic cascade, the recruitment and activity of other tumor-promoting leukocytes, and tumor responses to frontline therapies like irradiation and chemotherapy. Understanding the mechanisms controlling the recruitment, retention, and function of these cells could identify important targets for anti-cancer therapeutics.

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“…Developing such approaches requires a more detailed insight in the environmental stimuli that instruct TAM heterogeneity within a tumor, in the signalling pathways and effector molecules that contribute to TAM functionality and in the appreciation that macrophages residing in different tissues display different characteristics. Though more and more studies are appearing describing the presence, regulation and function of tumor-associated macrophages, Tie2-expressing monocytes and other myeloid cells in human tumors (eg[174,[182][183][184]), the available evidence for TAM heterogeneity in patients is scarce. Future work will need to identify useful markers to discriminate between human TAM subsets and to firmly establish correlations between particular TAM populations and outcome for the patient.A C C E P T E D M A N U S C R I P TAcknowledgements QL is supported by a grant from Stichting tegen Kanker.…”

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confidence: 99%

Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment

Lahmar

Keirsse

Laoui

et al. 2016

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

113

117

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The Frequency of Tumor-infiltrating Tie–2-expressing Monocytes in Renal Cell Carcinoma: Its Relationship to Angiogenesis and Progression

Cited by 21 publications

References 25 publications

Expression and significance of B7-H3 and Tie-2 in the tumor vasculature of clear cell renal carcinoma

Expression and significance of B7-H3 and Tie-2 in the tumor vasculature of clear cell renal carcinoma

The Multifaceted Role of Perivascular Macrophages in Tumors

Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment

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