The FTO Obesity Gene. Genotyping and Gene Expression Analysis in Morbidly Obese Patients

Zabena, Carina; González-Sánchez, José Luis; Martı́nez-Larrad, Marı́a Teresa; García, Antonio Torres; Alvarez-Fernández-Represa, Jesús; Anchuelo, Arturo Corbatón; Pérez-Barba, Milagros; Serrano-Rı́os, Manuel

doi:10.1007/s11695-008-9727-0

Cited by 88 publications

(77 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, in our study, the association of these parameters was independent of body weight. In accord with other study (38), no association between leptin levels and rs9939609 genotypes were detected. In the other hand, Zimmerman et al (23) reported an association between circulating leptin levels and FTO variant, but the effect was accounted for by BMI and that the FTO A-allele tended to lower IL-6 levels.…”

Section: Discussionsupporting

confidence: 89%

Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

et al. 2016

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 89%

Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

et al. 2016

View full text Add to dashboard Cite

“…To date, only a few studies have examined FTO gene expression in paired OAT and SAT and discordant results were reported. Some studies found no site-specific difference (20)(21)(22)33), while another study found a threefold higher FTO expression in SAT compared to visceral adipose tissue (16). The discrepancy of our results with these studies is difficult to interpret, but it is worth noting that our population included women exclusively, and covered the lean to moderately obese range while other studies reporting no difference were performed mostly in severely obese patients of both sexes.…”

Section: Figure 4 Effect Of Fto Silencing On 3t3-l1 Differentiation contrasting

confidence: 91%

“…However, the function of FTO and its role in human obesity and T2D remains to be defined. In particular, the association of FTO expression in adipose tissue with fat depot and with obesity still remains controversial in humans (16,(20)(21)(22)33). In addition, very few studies have investigated the relationship between FTO expression in adipose tissue and insulin sensitivity (18,21).…”

Section: Discussionmentioning

confidence: 99%

The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity

Bravard

Veilleux

Disse

et al. 2013

Obesity

View full text Add to dashboard Cite

Objective: The fat mass and obesity associated (FTO) gene is related to obesity, but the regulation of FTO expression in adipose tissue is not fully understood. We investigated FTO expression in paired subcutaneous and omental adipose tissues (SAT and OAT) from healthy women undergoing gynecological surgeries, and its relation with adiposity and insulin sensitivity. Design and Methods: FTO expression in SAT of type 2 diabetic patients treated or not with Rosiglitazone was also compared. Results: Both the mRNA and protein levels of FTO were higher in OAT from women than in SAT. Only OAT FTO protein levels negatively correlated with BMI and body fat mass, whereas SAT FTO mRNA levels were negatively correlated with subcutaneous fat deposition. In addition, SAT FTO mRNA and protein levels were increased in insulin resistant women (high HOMA) compared to insulin sensitive women (low HOMA), whereas OAT FTO expression was not different between these two subgroups. Interestingly, FTO mRNA levels were increased in SAT of type 2 diabetic patients, and treatment of diabetics with Rosiglitazone improved insulin sensitivity and reduced SAT FTO mRNA levels. Lastly, FTO expression was transiently increased in the early phase of 3T3-L1 cell differentiation, which coincides with the induction of PPARc2 expression. However, partial reduction of FTO did not impact PPARc2 expression and adipocyte differentiation. Conclusion: Therefore, FTO gene expression is higher in OAT than in SAT in lean to moderately obese women. OAT FTO expression is associated with adiposity, whereas SAT FTO expression is associated with insulin sensitivity. These associations are independent of an effect of FTO on adipocyte differentiation.

show abstract

“…1 A genome-wide search for obesity and type 2 diabetessusceptibility genes identified several variants in the fat mass-and obesity-associated (FTO) gene region on chromosome 16q12.2, which were strongly associated with obesityrelated traits and increased the risk for this disease. [2][3][4][5][6][7] The human FTO is widely expressed in both fetal and adult tissues, including mesenteric fat, pancreas, liver and adipose tissue, with the highest concentration found in the brain, specifically in the hypothalamus. 2,8 Obese subjects show increased levels of subcutaneous adipose tissue FTO mRNA compared with non-obese subjects.…”

Section: Introductionmentioning

confidence: 99%

Placental FTO expression relates to fetal growth

et al. 2010

View full text Add to dashboard Cite

Objective: The fat mass and obesity-associated gene (FTO) participates in the control of postnatal weight gain. We assessed whether FTO is expressed in human placenta and whether such expression relates to prenatal weight gain and to the rs9939609 single nucleotide polymorphism (SNP) in FTO. Design and subjects: In a birth cohort study, placentas from women (n ¼ 147) with an uncomplicated, singleton, term pregnancy were weighed at delivery. Real-time PCR was used to study, in placental tissue, the expression of FTO and of housekeeping genes (TATA box binding protein and succinate dehydrogenase complex, subunit A) and to genotype the rs9939609 SNP in FTO. Weights and lengths of the newborns were measured; circulating insulin and insulin-like growth factor-I (IGF-I) were quantified in cord blood. Results: FTO was highly expressed in placenta and was associated with increased fetal weight and length (Po0.001 to Po0.0001). Maternal parity showed an interaction (Po0.001) in the association between placental FTO expression and placental weight. Placental FTO mRNA expression was associated with increased fetal-to-placental weight ratio (Po0.005) in infants from primiparous women, and was associated with increased fetal weight and length and placental weight (Po0.001 to Po0.0001) in infants from nonprimiparous women. These associations were not explained by either cord insulin or IGF-I. Placental FTO expression was unrelated to placental FTO rs9939609 SNP Conclusion: FTO is expressed in the human placenta. In a maternal parity-dependent manner, placental FTO may participate either in the control of fetal weight gain or in the partitioning between placental and fetal growth.

show abstract

The FTO Obesity Gene. Genotyping and Gene Expression Analysis in Morbidly Obese Patients

Cited by 88 publications

References 57 publications

Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

Association of the rs9939609 gene variant in FTO with insulin resistance, carciovascular risk factor and serum adipokine levels in obese patients

The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity

Placental FTO expression relates to fetal growth

Contact Info

Product

Resources

About