1986
DOI: 10.1159/000195099
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The Function and Properties of Human Lung Mast Cells

Abstract: Mast cells may be recovered from human subjects by bronchoalveolar lavage. Such bronchoalveolar mast cells will release histamine in response to IgE-dependent challenge in a reaction that is dose-, time- and energy-dependent. They possess functional characteristics distinct from dispersed human lung mast cells. The percentage of mast cells within the bronchoalveolar cell population is critically dependent upon the underlying pathology. Greater numbers of mast cells may be recovered from the bronchoalveolar com… Show more

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Cited by 15 publications
(5 citation statements)
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“…The early phase reaction occurs ϳ15 min after allergen provocation and is thought to be mediated by allergen binding to IgE receptors on mast cells (9,55). Subsequently, this event leads to activation and the release of histamine and leukotrienes, triggering an immediate bronchoconstriction (19,22). In contrast, the late phase reaction begins 3-4 h used allergen provocation, peaks between 6 -12 h, and generally resolves within 24 h (8,13,19).…”
Section: Discussionmentioning
confidence: 99%
“…The early phase reaction occurs ϳ15 min after allergen provocation and is thought to be mediated by allergen binding to IgE receptors on mast cells (9,55). Subsequently, this event leads to activation and the release of histamine and leukotrienes, triggering an immediate bronchoconstriction (19,22). In contrast, the late phase reaction begins 3-4 h used allergen provocation, peaks between 6 -12 h, and generally resolves within 24 h (8,13,19).…”
Section: Discussionmentioning
confidence: 99%
“…The EPR in humans has been extensively studied and is likely a consequence of allergen-mediated cross-linking of IgE-Fc⑀R on mast cells initiating events leading to degranulation and the release of inflammatory mediators (e.g., histamine and leukotrienes) precipitating bronchoconstriction (7,9). In contrast to this working model in humans, reconstitution of OVA-sensitized/challenged B cell-deficient mice with IgG-depleted serum from OVA-sensitized/ challenged wild-type animals, restoring serum total IgE to wildtype levels in the recipients (i.e., 122 Ϯ 5 ng/ml), did not elicit an EPR following OVA provocation (Fig.…”
Section: Early Phase Bronchoconstriction In the Mouse Is Mediated Excmentioning
confidence: 99%
“…The current paradigm explaining the EPR in asthmatic subjects involves mechanisms in which allergen binds to, and cross-links, IgE receptors on mast cells (7,8). This event subsequently leads to activation and the release of histamine and leukotrienes, triggering an immediate bronchoconstrictive response (9,10). In contrast, the LPR begins ϳ3 h following allergen provocation, peaks between 6 -12 h, and generally resolves within 24 h (3,5).…”
mentioning
confidence: 99%
“…(17) Bronchial biopsies from atopic asthmatic subjects before and after treatment Decreased numbers of activated mast cells, eosinophils, CD4 + T cells, CD3 + T cells, CD8 + T cells; reduced expression of VCAM-1, ICAM-1, ELAM-1 Ref. (20) BAL mast cells from healthy, normal subjects Blocked mannitol-induced histamine release and anti-IgE-induced release of leukotriene C4 and prostaglandin C2 Ref. (19) Lung tissue from sensitized rats Inhibited histamine and SRS-A release Ref.…”
Section: Mechanism Of Actionmentioning
confidence: 99%