The function and regulatory mechanism of RNA-binding proteins in breast cancer and their future clinical treatment prospects

Abstract

Breast cancer is the most common female malignancy, but the mechanisms regulating gene expression leading to its development are complex. In recent years, as epigenetic research has intensified, RNA-binding proteins (RBPs) have been identified as a class of posttranscriptional regulators that can participate in regulating gene expression through the regulation of RNA stabilization and degradation, intracellular localization, alternative splicing and alternative polyadenylation, and translational control. RBPs play an important role in the development of normal mammary glands and breast cancer. Functional inactivation or abnormal expression of RBPs may be closely associated with breast cancer development. In this review, we focus on the function and regulatory mechanisms of RBPs in breast cancer, as well as the advantages and challenges of RBPs as potential diagnostic and therapeutic targets in breast cancer, and discuss the potential of RBPs in clinical treatment.

Dual RNA-seq to catalogue host and parasite gene expression changes associated with virulence of T. annulata-transformed bovine leukocytes: towards identification of attenuation biomarkers

“…TA03875 codes for RNA poly(A)-binding protein which is a post-transcriptional regulator of gene expression controlling mRNA stability, polyadenylation, and other functions. An aberrant expression of this gene has previously been reported to be associated with the development of breast cancer 64 , 65 , this gene was down-regulated in attenuated passage in the attenuated Beja passage (log2 Fold Change = − 0.9; p < 0.001). We also found that this gene contains a nucleus localization signal (NLS) which suggest its possible transport into the host nucleus, however this needs to be confirmed since previous studies showed that some genes such as TaMISHIP (T. annulata proline‐rich microtubule and SH3 domain‐interacting protein) presented NLS but they were not detected in the host nucleus 66 .…”

Viral Hijacking of Host RNA-binding Proteins: Implications for Viral Replication and Pathogenesis

“…For example, RBPs can act as cofactors for viral RNA polymerases or helicases, enhancing their activity and promoting efficient viral RNA synthesis [6,7]. Additionally, RBPs may regulate RNA stability and secondary structure, ensuring proper template recognition and efficient replication [8].…”

From the disruption of RNA metabolism to the targeting of RNA‐binding proteins: The case of polyglutamine spinocerebellar ataxias

“…During the process of developing therapies, it is necessary to consider the RBP effects in the context of polyQ SCAs, promoting the beneficial ones and reducing those that are harmful, with the final goal of restoring RNA homeostasis (Cornelius et al., 2022). To this end, some potential therapeutic strategies targeting RBPs can encompass gene‐coding delivery (Cornelius et al., 2022) and pharmacological agents (Lu et al., 2022).…”