The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis

Chung, Tae‐Wook; Choi, Hee‐Jung; Park, Mi-Ju; Choi, Hyun Ki; Lee, Syng‐Ook; Kim, Keuk‐Jun; Kim, Cheorl-Ho; Hong, Changwan; Kim, Kyun-Ha; Joo, Myungsoo; Ha, Ki‐Tae

doi:10.18632/oncotarget.13878

Cited by 16 publications

(12 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overexpression of neoplastic gangliosides also results in tumour-specific immune response inhibition via interaction with Siglec-7 protein ( Kawasaki et al, 2010 ). Moreover, cancer cells tend to release large amounts of gangliosides to the neoplastic microenvironment ( Chung et al, 2017 ). Interactions with ganglioside receptors on the surface are crucial for vascular endothelial growth factor (VEGF) signalling pathway activation, resulting in angiogenesis ( Lang et al, 2001 ).…”

Section: Membrane Phospholipidsmentioning

confidence: 99%

“…Mutations or altered expression of genes involved in ganglioside biosynthetic pathways result in ganglioside membrane levels abnormalities. Despite the great importance of gangliosides and cerebrosides in cancer development, it should be remembered that the lipids act also as antigens, and therefore their role may be much more complex ( Chung et al, 2017 ).…”

Section: Membrane Phospholipidsmentioning

confidence: 99%

See 1 more Smart Citation

Lipid composition of the cancer cell membrane

Szlasa

Zendran

Zalesińska

et al. 2020

J Bioenerg Biomembr

266

191

View full text Add to dashboard Cite

Cancer cell possesses numerous adaptations to resist the immune system response and chemotherapy. One of the most significant properties of the neoplastic cells is the altered lipid metabolism, and consequently, the abnormal cell membrane composition. Like in the case of phosphatidylcholine, these changes result in the modulation of certain enzymes and accumulation of energetic material, which could be used for a higher proliferation rate. The changes are so prominent, that some lipids, such as phosphatidylserines, could even be considered as the cancer biomarkers. Additionally, some changes of biophysical properties of cell membranes lead to the higher resistance to chemotherapy, and finally to the disturbances in signalling pathways. Namely, the increased levels of certain lipids, like for instance phosphatidylserine, lead to the attenuation of the immune system response. Also, changes in lipid saturation prevent the cells from demanding conditions of the microenvironment. Particularly interesting is the significance of cell membrane cholesterol content in the modulation of metastasis. This review paper discusses the roles of each lipid type in cancer physiology. The review combined theoretical data with clinical studies to show novel therapeutic options concerning the modulation of cell membranes in oncology.

show abstract

Section: Membrane Phospholipidsmentioning

confidence: 99%

Section: Membrane Phospholipidsmentioning

confidence: 99%

Lipid composition of the cancer cell membrane

Szlasa

Zendran

Zalesińska

et al. 2020

J Bioenerg Biomembr

266

191

View full text Add to dashboard Cite

show abstract

“…Macrophages and microglia within the glioma microenvironment produce CCL2, which is critical for recruiting regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC) [ 43 ]. Additionally, tumor-derived angiogenesis induced by co-treatment of ganglioside GM1 and macrophages was reduced by the addition of the CCR2 antagonist RS102895 [ 44 ]. These evidences further verify that CCL2/CCR2 signaling is involved in the tumor microenvironment, which explained why l -CDL decreased the volume of tumor and diminished angiogenesis, and alleviated the TCIP after sciatic nerve injury.…”

Section: Discussionmentioning

confidence: 99%

Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway

Kodithuwakku

Zhou

et al. 2017

Molecules

View full text Add to dashboard Cite

Background: Tumor compression-induced pain (TCIP) is a complex pathological cancer pain. Spinal glial cells play a critical role in maintenance of cancer pain by releasing proinflammatory cytokines and chemokines. In this study, we verified the role of levo-corydalmine (l-CDL) on TCIP. Methods: Spontaneous pain, paw withdrawal threshold and latency were assessed using TCIP mouse model. Immunofluorescence was used to identify the reactions of glia. RT-PCR and western blot or ELISA were used to determine mRNA or protein expression of tumor necrosis factor-α (TNF-α), interlukin-1β (IL-1β), CC chemokine ligand 2 (CCL2) and chemotactic cytokine receptor 2 (CCR2) in vivo and in vitro. Results: l-CDL significantly attenuated TCIP hypersensitivity, accompanying with downregulation of TNF-α and IL-1β expression levels and declined astrocytes and microglial activation. It also significantly decreased the expression of the mRNA and protein level for CCL2 and CCR2. Further, l-CDL could suppress TNF-α-induced astrocytes activation and IL-1β expression through downregulating the CCL2/CCR2. Besides, CCL2-induced BV-microglia activation and inflammatory factors secretion were suppressed by l-CDL via CCR2. Conclusions: Suppression of CCL2/CCR2 by l-CDL may contribute to alleviate TCIP, offering an alternative medication for TCIP.

show abstract

“…GM3 synthase levels are significantly higher in human monocyte-derived macrophages than in monocytes and GM3 has been considered as a physiological modulator of macrophage differentiation in human atherosclerotic aorta [78]. In bone marrow-derived macrophages, peritoneal macrophages and the Raw264.7 macrophage cell line, exogenous GM1 contributes to the induction of arginase-1, a major M2 macrophage marker, and to the secretion of monocyte chemoattractant protein-1 (MCP-1) through CD206-mediated activation of signal transducer and activator of transcription (STAT) 6 [48].…”

Section: Inflammatory Cells and Gangliosidesmentioning

confidence: 99%

Vascular Diseases and Gangliosides

Sasaki

Toyoda

2019

IJMS

View full text Add to dashboard Cite

Vascular diseases, such as myocardial infarction and cerebral infarction, are most commonly caused by atherosclerosis, one of the leading causes of death worldwide. Risk factors for atherosclerosis include lifestyle and aging. It has been reported that lifespan could be extended in mice by targeting senescent cells, which led to the suppression of aging-related diseases, such as vascular diseases. However, the molecular mechanisms underlying the contribution of aging to vascular diseases are still not well understood. Several types of cells, such as vascular (endothelial cell), vascular-associated (smooth muscle cell and fibroblast) and inflammatory cells, are involved in plaque formation, plaque rupture and thrombus formation, which result in atherosclerosis. Gangliosides, a group of glycosphingolipids, are expressed on the surface of vascular, vascular-associated and inflammatory cells, where they play functional roles. Clarifying the role of gangliosides in atherosclerosis and their relationship with aging is fundamental to develop novel prevention and treatment methods for vascular diseases based on targeting gangliosides. In this review, we highlight the involvement and possible contribution of gangliosides to vascular diseases and further discuss their relationship with aging.

show abstract

The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis

Cited by 16 publications

References 51 publications

Lipid composition of the cancer cell membrane

Lipid composition of the cancer cell membrane

Levo-Corydalmine Alleviates Neuropathic Cancer Pain Induced by Tumor Compression via the CCL2/CCR2 Pathway

Vascular Diseases and Gangliosides

Contact Info

Product

Resources

About