The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response

Dougherty, Graeme J.; Murdoch, Sarah J.; Hogg, Nancy

doi:10.1002/eji.1830180107

Cited by 322 publications

(141 citation statements)

References 23 publications

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“…[41][42][43] Recently, CD21 has been shown to mediate homotypic and heterotypic cell binding of normal B cells and B cell lines through adhesion to its ligand, CD23. [44][45][46] Since anti-CD21 but not anti-CD23 impaired the anti-CD19-induced aggregation of B-CLL cells, CD21 appears to employ a ligand different from CD23 for this homotypic adhesion.…”

Section: Discussionmentioning

confidence: 99%

Differential adhesion pattern of B cell chronic lymphocytic leukemia cells

Behr

Korinth²,

Schriever³

1998

Leukemia

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Section: Discussionmentioning

confidence: 99%

Differential adhesion pattern of B cell chronic lymphocytic leukemia cells

Behr

Korinth²,

Schriever³

1998

Leukemia

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“…It has been reported that ICAM-1 is expressed on the surface of resting peripheral blood leukocytes, and that its expression is increased by activation of monocytes, T lymphocytes, and B lymphocytes (22,23). Since 1983, we have analyzed subsets of peripheral blood mononuclear cells, including monocyte/macrophages, in patients with KD by fluorescence-activated cell sorter.…”

Section: Discussionmentioning

confidence: 99%

Increased levels of circulating intercellular adhesion molecule 1 in kawasaki disease

Furukawa

Imai

Matsubara

et al. 1992

Arthritis & Rheumatism

134

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Objective. We investigated whether levels of intercellular adhesion molecule 1 (ICAM-1) antigen shed into the circulation increase during acute Kawasaki disease (KD). We also compared ICAM-1 levels in acute KD with those in anaphylactoid purpura (AP) and in measles.Methods. Serum ICAM-1 levels were measured by a double-determinant immunoassay using 2 monoclonal antibodies in the FAST (Falcon assay screening test) system. Serum levels of tumor necrosis factor a (TNFa) were measured by a specific and sensitive sandwich enzyme immunoassay.Results. Patients with KD, but not those with AP or measles, had increased levels of shed ICAM-1 antigen in serum samples obtained during acute stages. Moreover, during the acute stage, KD patients with coronary artery lesions (CAL) had still higher levels of shed ICAM-1 than did those without CAL. We found a

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“…Recent studies of mouse fibroblasts transfected with ICAM-1 and HLA class I1 genes show that they have a markedly enhanced ability to present antigen to human T lymphocytes, as compared with fibroblasts transfected with HLA class I1 genes only (27), and it has been suggested that ICAM-I has a function in the generation of an immune response (28). Thus, it is reasonable to postulate that fibroblasts in the RA pannus with both up-regulated JCAM-I and HLA class I1 antigens may play a major role in antigen presentation and subsequent maintenance of chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Role of cytokines in inflammatory synovitis

Chin

Winterrowd

Krzesicki

et al. 1990

Arthritis & Rheumatism

118

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This study was undertaken in an effort to understand the role of cytokines in T lymphocyte trafficking into inflamed synovium and in the potential enhancement of antigen presentation by human synovial fibroblasts. We found that interleukin-lp (IL-lp), tumor necrosis factor a (TNFa), and interferon-y (IFNy) each increased the cell surface expression of intercellular adhesion molecule I (ICAM-I) on human synovial fibroblasts in a dose-and time-dependent manner. Maximal ICAM-1 expression occurred within 8 hours of induction, with the following order of efficacy: IFNy > TNFa > IL-1p. The number of cells bearing the ICAM-1 antigen also increased, from a basal level of -30% to more than 83% after cytokine induction (for all 3 cytokines). ICAM-1 expression rapidly decreased fdlowing cytokine removal. The expression of lymphocyte function-associated antigen 3 was also examined, but it was not changed by any of the 3 cytokines. Class I major histocompatibility complex antigen expression was increased modestly by all 3 cytokines, and expression was maximal by 24 hours after treatment. Only IFNy induced HLA class I1 antigen expression, and this expression persisted for up to 6 days following removal of the lymphokine. IL-6 and granulocyte-macrophage colony- stimulating factor had no effect on any of the parameters examined. Our data support an interactive role for inflammatory cytokines and the expression of adhesion ligands and HLA antigens by human synovial fibroblasts in the pathogenesis of synovial inflammation in rheumatoid arthritis.Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized in part by the proliferation of pannus tissue in diseased joints, which leads to eventual degradation of the articular cartilage and the subchondral bone (1)(2)(3). It has been demonstrated that the RA synovium contains cells that express HLA-DR antigens (4-7). There is also evidence that indicates that cells populating the inflamed tissue lining the RA joint have adhesion molecules as ligands for homing receptors on circulating T lymphocytes (8,9). It is hypothesized that the increased adhesiveness of the inflamed synovial tissue may play a central role in lymphocyte homing and retention in the diseased joint. The current study was initiated in an effort to elucidate cellular mechanisms that may be involved in chronic inflammatory synovitis. We examined the time and dose effects of various cytokines present in the inflammatory microenvironment in RA (10) on the expression of adhesion ligands intercellular adhesion molecule I (ICAM-1) and lymphocyte function-associated antigen 3 (LFA-3), and the expression of class I and class I1 major histocompatibility complex (MHC) antigens, 4 fibroblast cell surface molecules whose regulation may play critical roles in synovial inflammation.In previous studies, interferon-y (IFNy) has been shown to induce the expression of class I1 MHC antigens on synovial fibroblasts (1 l), and ICAM-1 has MATERIALS AND METHODSRecombinant cytokines and antibodies. Recombinant human i...

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The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response

Cited by 322 publications

References 23 publications

Differential adhesion pattern of B cell chronic lymphocytic leukemia cells

Differential adhesion pattern of B cell chronic lymphocytic leukemia cells

Increased levels of circulating intercellular adhesion molecule 1 in kawasaki disease

Role of cytokines in inflammatory synovitis

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