The Function of lncRNAs as Epigenetic Regulators

Ayub, Ana Luísa Pedroso; Papaiz, Debora D’Angelo; Soares, Roseli da Silva; Jasiulionis, Miriam Galvonas

doi:10.5772/intechopen.88071

Cited by 2 publications

(1 citation statement)

References 70 publications

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“…In the signal archetype, the lncRNA sends a molecular signal to initiate regulation at the transcriptional level in response to different stimuli [ 35 , 45 ]. For instance, KCNQ1OT1 recruits PRC2 and chromatin-modifying enzymes (histone methyltransferases) by acting as a signal lncRNA [ 46 ].…”

Section: Lncrna Mechanisms Of Actionmentioning

confidence: 99%

Long Non-Coding RNAs and Their Potential Roles in the Vector–Host–Pathogen Triad

Ahmad

Bensaoud

Mekki

et al. 2021

Life

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Long non-coding (lnc)RNAs have emerged as critical regulators of gene expression and are involved in almost every cellular process. They can bind to other molecules including DNA, proteins, or even other RNA types such messenger RNA or small RNAs. LncRNAs are typically expressed at much lower levels than mRNA, and their expression is often restricted to tissue- or time-specific developmental stages. They are also involved in several inter-species interactions, including vector–host–pathogen interactions, where they can be either vector/host-derived or encoded by pathogens. In these interactions, they function via multiple mechanisms including regulating pathogen growth and replication or via cell-autonomous antimicrobial defense mechanisms. Recent advances suggest that characterizing lncRNAs and their targets in different species may hold the key to understanding the role of this class of non-coding RNA in interspecies crosstalk. In this review, we present a general overview of recent studies related to lncRNA-related regulation of gene expression as well as their possible involvement in regulating vector–host–pathogen interactions.

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Section: Lncrna Mechanisms Of Actionmentioning

confidence: 99%

Long Non-Coding RNAs and Their Potential Roles in the Vector–Host–Pathogen Triad

Ahmad

Bensaoud

Mekki

et al. 2021

Life

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Epigenetic Features in Uterine Leiomyosarcoma and Endometrial Stromal Sarcomas: An Overview of the Literature

et al. 2022

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There is a consensus that epigenetic alterations play a key role in cancer initiation and its biology. Studies evaluating the modification in the DNA methylation and chromatin remodeling patterns, as well as gene regulation profile by non-coding RNAs (ncRNAs) have led to the development of novel therapeutic approaches to treat several tumor types. Indeed, despite clinical and translational challenges, combinatorial therapies employing agents targeting epigenetic modifications with conventional approaches have shown encouraging results. However, for rare neoplasia such as uterine leiomyosarcomas (LMS) and endometrial stromal sarcomas (ESS), treatment options are still limited. LMS has high chromosomal instability and molecular derangements, while ESS can present a specific gene fusion signature. Although they are the most frequent types of “pure” uterine sarcomas, these tumors are difficult to diagnose, have high rates of recurrence, and frequently develop resistance to current treatment options. The challenges involving the management of these tumors arise from the fact that the molecular mechanisms governing their progression have not been entirely elucidated. Hence, to fill this gap and highlight the importance of ongoing and future studies, we have cross-referenced the literature on uterine LMS and ESS and compiled the most relevant epigenetic studies, published between 2009 and 2022.

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The Function of lncRNAs as Epigenetic Regulators

Cited by 2 publications

References 70 publications

Long Non-Coding RNAs and Their Potential Roles in the Vector–Host–Pathogen Triad

Long Non-Coding RNAs and Their Potential Roles in the Vector–Host–Pathogen Triad

Epigenetic Features in Uterine Leiomyosarcoma and Endometrial Stromal Sarcomas: An Overview of the Literature

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