The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men

Polonikov, Alexey; Yarosh, Sergey L.; Кохтенко, Е. В.; Starodubova, Nina I.; Пахомов, С. П.; Orlova, V. S.

doi:10.1016/j.fertnstert.2009.11.006

Cited by 26 publications

(16 citation statements)

References 19 publications

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“…However, one study in Russian men with idiopathic infertility reported an increase in risk for infertility with nondeletion genotype of the GSTT1 gene. 23 Also, there are two case-control studies in which the role of GSTT1, GSTM1 genotypes in male infertility has been addressed in patients with varicocele. 29,30 Okubo et al 29 concluded that the response rate to varicocelectomy is significantly better in patients with the GSTT1 genotype than the GSTT1-null genotype.…”

Section: Discussionmentioning

confidence: 99%

“…Aydemir et al 22 reported that in patients with idiopathic infertility, GSTM1 polymorphism might be an important source of variation in susceptibility of spermatozoa to oxidative damage. In a study conducted in Russian men, Polonikov et al 23 reported that the nondeletion genotype of the GSTT1 gene is strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia. Wu et al 24 reported that there was no statistically significant association between GSTT1 null genotype and Chinese infertile patients with varicocele.…”

Section: Introductionmentioning

confidence: 99%

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The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

2010

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The effects of the GST genes (GSTM1, GSTT1 and GSTP1) on male factor infertility have not been well elucidated. A casecontrol study was performed to investigate the association between functionally important polymorphisms in GST genes and idiopathic male infertility. The study group consisted of 166 men suffering from idiopathic oligoasthenoteratozoospermia (OAT) and an equal number of age-matched healthy fertile male controls. Genomic DNA extracted from the peripheral blood, was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Multivariate regression analysis showed an increase in risk to infertility in the patients with null genotype of GSTM1 (OR: 2.18; 95% CI: 1.64-3.32; P¼0.001) or GSTT1 (OR: 1.88; 95% CI:1.12-2.52; P¼0.04). Our data further showed that combination of deletion genotypes of GST (GSTM1 and GSTT1) pose an even higher risk of infertility. In addition, GSTP1 wild-type genotype in combination with GSTM1 null or GSTT1 null genotype increased probability for infertility (OR: 2.47, 95% CI: 1.46-4.17: and OR: 2.69, 95% CI: 1.39-5.32, respectively). Similarly a much higher risk for infertility was noted in the patients carrying a genotype combination of GSTM1 null, GSTT1 null and GSTP1 (Ile/Ile) (OR: 4.45; 95% CI: 1.59-12.24; P¼0.002). The variant genotypes of GSTP1 (Ile/Val and Val/Val) resulted in a significant decreased risk to infertility in the cases (OR: 0.44; 95% CI: 0.29-0.78, P¼0.004). These results support the hypothesis of increased risk of GSTM1 or GSTT1null genotypes for developing infertility, but the nondeletion GSTM1 and GSTT1genotypes emerged as protective factors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

2010

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“…The characteristics of selected studies are summarized in Table 1. A total of 12 eligible studies met the inclusion criteria, including 11 studies for GSTM1 [14,15,[25][26][27][28][29][30][31][32][33] and 9 ones for GSTT1 [17,26,27,[29][30][31][32][33]. All the included studies were case-control studies.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

“…GSTT1 has functional polymorphisms that result in the virtual absence of enzyme activity [13]. Polonikov et al [15] reported that the nondeletion genotype of the GSTT1 gene is strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia. In a study conducted in Chinese men, Wu et al [16] reported that there was no statistically significant association between GSTT1 null genotype and infertile patients with varicocele.…”

Section: Introductionmentioning

confidence: 99%

Association of the Glutathione S-transferases M1 and T1 polymorphism with male infertility: a meta-analysis

Song

Zhao

Cai

et al. 2012

J Assist Reprod Genet

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Background Genes of different pathways regulate spermatogenesis, and the complexity of the spermatogenic process indicates that polymorphisms or mutations in these genes could cause male infertility. Published data on the association between the GSTM1 and GSTT1 polymorphism and male infertility risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Methods A total of 11 studies regarding GSTM1 and 9 studies regarding GSTT1 between 1999 and 2012 were identified through researching MEDLINE, EMBASE and the Chinese Biomedical Database. It was performed to obtain summary estimated odd ratios and 95 % confidence intervals of GSTM1 and GSTT1 for male infertility, with attention to study quality and publication bias. Results Overall, a significant association was seen between GSTM1 (OR01.20, 95 % CI 01.02-1.40, P heterogeneity 0 0.000, P00.027) genotypes and male infertility. Significant associations were also observed in subgroups of Caucasian populations (OR01.65, 95 %CI01.16-2.34, P heterogeneity 0 0.006, P00.005), but were not observed in Asian populations (OR01.09, 95 % CI00.72-1.65, P heterogeneity 00.054, P00.697) when stratified by ethnicity. While there was no significant association was seen between GSTT1 (OR0 1.00, 95 % CI00.74-1.35, P heterogeneity 00.000, P00.980) null genotypes and male infertility. Simultaneously, significant associations were not observed in subgroups of Caucasian populations (OR 00.94, 95 %CI 00.44-2.00, P heterogeneity 00.000, P 00.867) and Asian populations (OR00.93, 95 % CI00.46-1.87, P heterogeneity 00.002, P0 0.838) when stratified by ethnicity. Conclusion Our results suggest the GSTM1 null genotype contributes to male infertility susceptibility, while GSTT1 gene polymorphisms are not associated with male infertility in our study.

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“…Polymorphic genes for xenobiotic-metabolizing enzymes are considered to be important modifiers of susceptibility to male infertility (Aydos et al, 2009;Rubes et al, 2010;Schuppe et al, 2000;Yarosh et al, 2013). Many studies have observed that functional polymorphisms in genes such as CYP1A1, GSTM1 and GSTT1 are associated with the risk of idiopathic male infertility (Aydos et al, 2009;Jaiswal et al, 2012;Polonikov et al, 2010;Safarinejad et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility

Yarosh

Кохтенко

Churnosov

et al. 2014

Reproductive BioMedicine Online

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The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men

Cited by 26 publications

References 19 publications

The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

Association of the Glutathione S-transferases M1 and T1 polymorphism with male infertility: a meta-analysis

Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility

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