“…Seed-based classification was done by first thresholding the images such that only voxels with at least 10 samples were kept (21,45,92). Following standard procedures, voxel values were converted into proportions, such that the value at each voxel becomes the number of tracts reaching the target mask for that voxel, divided by the number of tracts that reach any of the 10 a priori target masks based on single or a combination of the standard automated anatomical labeling (AAL) maps [AAL map numbers within parentheses (21,45)]: mOFC (28,6,26), vlPFC (10,16), IFG (triangular partIFG: 14), dlPFC (4,8), PCC (68), ACC (32), dACC (34), hippocampus (38), amygdala (42), and SMA (20). The striatum mask was based on the combined striatal volumes produced by the freesurfer subcortical segmentation algorithm.…”