The future of CRISPR gene editing according to plant scientists

Lange, Job de; Nalley, Lawton Lanier; Yang, Wei; Shew, Aaron M.; Steur, Hans De

doi:10.1016/j.isci.2022.105012

Cited by 8 publications

(1 citation statement)

References 72 publications

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“…are the most deleterious pathogenic oomycetes [75]. The studies mitigating the risk of oomycetes disease via CRISPR-based technologies are limited and mainly focus on editing the effectors [76]. Targeting the transient expression of TcNPR3 in the leaves of Theobroma coca has achieved resistance against the pathogen P. tropicalis [77].…”

Section: Diseases Resistance Against Oomycetesmentioning

confidence: 99%

Recent Trends and Advancements in CRISPR-Based Tools for Enhancing Resistance against Plant Pathogens

Ijaz

Khan

Zaki

et al. 2023

Plants

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Targeted genome editing technologies are becoming the most important and widely used genetic tools in studies of phytopathology. The “clustered regularly interspaced short palindromic repeats (CRISPR)” and its accompanying proteins (Cas) have been first identified as a natural system associated with the adaptive immunity of prokaryotes that have been successfully used in various genome-editing techniques because of its flexibility, simplicity, and high efficiency in recent years. In this review, we have provided a general idea about different CRISPR/Cas systems and their uses in phytopathology. This review focuses on the benefits of knock-down technologies for targeting important genes involved in the susceptibility and gaining resistance against viral, bacterial, and fungal pathogens by targeting the negative regulators of defense pathways of hosts in crop plants via different CRISPR/Cas systems. Moreover, the possible strategies to employ CRISPR/Cas system for improving pathogen resistance in plants and studying plant–pathogen interactions have been discussed.

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Section: Diseases Resistance Against Oomycetesmentioning

confidence: 99%

Recent Trends and Advancements in CRISPR-Based Tools for Enhancing Resistance against Plant Pathogens

Ijaz

Khan

Zaki

et al. 2023

Plants

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CRISPR/Cas Systems for Enhancing Photosynthesis: Climate Resilience and Food Production

Barupal,

Kumar

2024

Gene Editing in Plants

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Exploring diverse food system actor perspectives on gene editing: a systematic review of socio-cultural factors influencing acceptability

Henderson,

Lang,

Kemper

et al. 2023

Agric Hum Values

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Despite the promise of new gene editing technologies (GETs) (e.g., CRISPR) in accelerating sustainable agri-food production, the social acceptability of these technologies remains unclear. Prior literature has primarily addressed the regulatory and economic issues impacting GETs ongoing acceptability, while little work has examined socio-cultural impacts despite evolving food policies and product commercialisation demanding input from various actors in the food system. Our systematic review across four databases addresses this gap by synthesising recent research on food system actors’ perspectives to identify the key socio-cultural factors influencing GET acceptability. This review extends prior literature by including views from a more diverse range of actors (e.g., farmers and NGOs) and provides a better understanding of their perceived social benefits and concerns. We find food system actors perceive positive and negative impacts of using GETs in agriculture. These perspectives are often entangled in broader debates regarding sustainability and food systems issues (e.g., social justice). We discuss practical recommendations for policymakers, agri-food industry managers, and scientists to better align gene edited foods (GEFs) with food system actors’ values. GEF policy, development, and commercialisation must reflect social values such as collective wellbeing and transparency to improve actors’ acceptability. More research is required among marginalised food actors such as Indigenous and smallholder farmers.

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The future of CRISPR gene editing according to plant scientists

Cited by 8 publications

References 72 publications

Recent Trends and Advancements in CRISPR-Based Tools for Enhancing Resistance against Plant Pathogens

Recent Trends and Advancements in CRISPR-Based Tools for Enhancing Resistance against Plant Pathogens

CRISPR/Cas Systems for Enhancing Photosynthesis: Climate Resilience and Food Production

Exploring diverse food system actor perspectives on gene editing: a systematic review of socio-cultural factors influencing acceptability

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