The purpose of the research conducted by the authors is to identify key problems in organizing the digital security of technology parks as prototypes of the "smart city" and points of innovative development of the economy. In the research the authors adhered to the hypothesis that the development in Technopolis's of a single digital platform for the interaction of the management company, residents, government bodies will serve as the basis for the development of the regional economy if key informational cyber threats are considered taking into account the maturity of business processes of organizations and newly involved information technologies. Within the framework of the article different tasks were solved. They were an analysis of automation efficiency of key business processes in resident companies and the management company; comparison the approaches of leaders in the digital transformation of the business to the choice of information technology / systems to form the "digital layer" of the organization; development of guidelines for the digital security of information systems of representatives in the real sector of the economy on a single digital platform. The empirical material of the research were 169 technology parks of the Russian Federation, which were evaluated in terms of information openness and contribution to the sustainable development of the region. Information openness involved an assessment of the information systems and technologies used by foreign resident companies (including Indonesia). The methodology of the study is based on statistical methods of research, observation, survey, and comparison. The main result of the study is the identification and ranking of digital security threats for technology parks as prototypes of "smart cities" in terms of importance, development of recommendations for monitoring projects of digital business transformation in an unstable environment. The paper clarifies the features of building information systems of resident companies during their integration into the information system of a Technopolis's and further into a single digital platform. The authors' basic research area is the digital security of information systems of industrial organizations under the conditions of the development of smart contract technologies, predictive analytics, reverse engineering, and enhanced digital qualified signatures. The authors consider the further research development in this area as improvement of interaction mechanisms of single digital platforms of Technopolis's with state authorities, financial institutions, and fiscal authorities, as well as with investors, both in the Russian Federation and Indonesia.