The future of SPECT in a time of PET

Jansen, Floris; Vanderheyden, Jean-Luc

doi:10.1016/j.nucmedbio.2007.06.013

Cited by 49 publications

(23 citation statements)

References 6 publications

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“…Though SPECT technology has been widely relied upon over the last few decades, only a limited number of new SPECT radiopharmaceuticals have been developed in the recent times compared to large number of interesting PET tracers which are continuously being reported from different parts of the world for clinical diagnosis (26–29). The major reasons for the decreasing interest in SPECT are its lower sensitivity and resolution compared to PET.…”

Section: Single-photon Emission Computed Tomographymentioning

confidence: 99%

Image-Guided Drug Delivery with Single-Photon Emission Computed Tomography: A Review of Literature

Chakravarty

Hong²,

Cai³

2015

CDT

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Tremendous resources are being invested all over the world for prevention, diagnosis, and treatment of various types of cancer. Successful cancer management depends on accurate diagnosis of the disease along with precise therapeutic protocol. The conventional systemic drug delivery approaches generally cannot completely remove the competent cancer cells without surpassing the toxicity limits to normal tissues. Therefore, development of efficient drug delivery systems holds prime importance in medicine and healthcare. Also, molecular imaging can play an increasingly important and revolutionizing role in disease management. Synergistic use of molecular imaging and targeted drug delivery approaches provides unique opportunities in a relatively new area called `image-guided drug delivery' (IGDD). Single-photon emission computed tomography (SPECT) is the most widely used nuclear imaging modality in clinical context and is increasingly being used to guide targeted therapeutics. The innovations in material science have fueled the development of efficient drug carriers based on, polymers, liposomes, micelles, dendrimers, microparticles, nanoparticles, etc. Efficient utilization of these drug carriers along with SPECT imaging technology have the potential to transform patient care by personalizing therapy to the individual patient, lessening the invasiveness of conventional treatment procedures and rapidly monitoring the therapeutic efficacy. SPECT-IGDD is not only effective for treatment of cancer but might also find utility in management of several other diseases. Herein, we provide a concise overview of the latest advances in SPECT-IGDD procedures and discuss the challenges and opportunities for advancement of the field.

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Section: Single-photon Emission Computed Tomographymentioning

confidence: 99%

Image-Guided Drug Delivery with Single-Photon Emission Computed Tomography: A Review of Literature

Chakravarty

Hong²,

Cai³

2015

CDT

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“…Image quality is a tradeoff between resolution, sensitivity, field of view (FOV) and detector area [14]. While overall image quality in PET is considered superior for many applications, the new advances in instrumentation and software have made SPECT highly valued.…”

Section: Image Qualitymentioning

confidence: 99%

Radiotracers for SPECT imaging: current scenario and future prospects

Adak¹,

Bhalla²,

Raj³

et al. 2011

Radiochimica Acta

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Summary. Single photon emission computed tomography (SPECT) has been the cornerstone of nuclear medicine and today it is widely used to detect molecular changes in cardiovascular, neurological and oncological diseases. While SPECT has been available since the 1980s, advances in instrumentation hardware, software and the availability of new radiotracers that are creating a revival in SPECT imaging are reviewed in this paper.The biggest change in the last decade has been the fusion of CT with SPECT, which has improved attenuation correction and image quality. Advances in collimator design, replacement of sodium iodide crystals in the detectors with cadmium zinc telluride (CZT) detectors as well as advances in software and reconstruction algorithms have all helped to retain SPECT as a much needed and used technology.Today, a wide spectrum of radiotracers is available for use in cardiovascular, neurology and oncology applications. The development of several radiotracers for neurological disorders is briefly described in this review, including [123 I]FP-CIT (DaTSCAN™) available for Parkinson's disease. In cardiology, while technetium-99m labeled tetrofosmin and technetium-99m labeled sestamibi have been well known for myocardial perfusion imaging, we describe a recently completed multicenter clinical study on the use of [ 123 I]mIBG (AdreView™) for imaging in chronic heart failure patients. For oncology, while bone scanning has been prevalent, newer radiotracers that target cancer mechanisms are being developed. Technetium-99m labeled RGD peptides have been reported in the literature that can be used for imaging angiogenesis, while technetium-99m labeled duramycin has been used to image apoptosis.While PET/CT is considered to be the more advanced technology particularly for oncology applications, SPECT continues to be the modality of choice and the workhorse in many hospitals and nuclear medicine centers. The cost of SPECT instruments also makes them more attractive in developing countries where the cost of a scan is still prohibitive for many patients.

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“…The sensitivity of a preclinical PET for the detection of annihilation events is 2–4% and provides images with a spatial resolution of 1–2 mm, 123,146 whereas the sensitivity of a preclinical SPECT is approximately 0.3% and provides images with a spatial resolution of ≈0.5 mm. 123,146 A broad comparative analysis of relative strengths and limitations of SPECT and PET can be found elsewhere. 146,147 PET is 10 times as sensitive as SPECT.…”

Section: Nuclear Imaging Modalitiesmentioning

confidence: 99%

“…123,146 A broad comparative analysis of relative strengths and limitations of SPECT and PET can be found elsewhere. 146,147 PET is 10 times as sensitive as SPECT. On the other hand, availability of large number of radionuclides, simultaneous imaging of multiple agents, cost-effectiveness, and adaptability to specific imaging situations are amongst the few advantages of SPECT.…”

Section: Nuclear Imaging Modalitiesmentioning

confidence: 99%

Whole animal imaging

Sandhu

Solorio

Broome

et al. 2010

WIREs Mechanisms of Disease

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Translational research plays a vital role in understanding the underlying pathophysiology of human diseases, and hence development of new diagnostic and therapeutic options for their management. After creating an animal disease model, pathophysiologic changes and effects of a therapeutic intervention on them are often evaluated on the animals using immunohistologic or imaging techniques. In contrast to the immunohistologic techniques, the imaging techniques are noninvasive and hence can be used to investigate the whole animal, oftentimes in a single exam which provides opportunities to perform longitudinal studies and dynamic imaging of the same subject, and hence minimizes the experimental variability, requirement for the number of animals, and the time to perform a given experiment. Whole animal imaging can be performed by a number of techniques including x-ray computed tomography, magnetic resonance imaging, ultrasound imaging, positron emission tomography, single photon emission computed tomography, fluorescence imaging, and bioluminescence imaging, among others. Individual imaging techniques provide different kinds of information regarding the structure, metabolism, and physiology of the animal. Each technique has its own strengths and weaknesses, and none serves every purpose of image acquisition from all regions of an animal. In this review, a broad overview of basic principles, available contrast mechanisms, applications, challenges, and future prospects of many imaging techniques employed for whole animal imaging is provided. Our main goal is to briefly describe the current state of art to researchers and advanced students with a strong background in the field of animal research.

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The future of SPECT in a time of PET

Cited by 49 publications

References 6 publications

Image-Guided Drug Delivery with Single-Photon Emission Computed Tomography: A Review of Literature

Image-Guided Drug Delivery with Single-Photon Emission Computed Tomography: A Review of Literature

Radiotracers for SPECT imaging: current scenario and future prospects

Whole animal imaging

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