The Future of the N. E. A.

Harris, William T.; Greenwood, J. M.; Schaeffer, Nathan C.; Green, James M.; Bardeen, C. W.; Keyes, Charles H.; Mott, T. A.; Carr, J. W.; McAndrew, William

doi:10.1177/002205740506200101

Journal of Education

1905

DOI: 10.1177/002205740506200101

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The Future of the N. E. A.

William T. Harris¹,

J. M. Greenwood²,

Nathan C. Schaeffer³

et al.

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1988

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“…Several studies have shown that antibodies binding to solid-phase cardiolipin also hind readily lo other negatively charged phospholipids such as phosphatidylserine and phosphatidylinositol. and sevenit groups of cardioiipin-binding antibodies differing in specificity have been described [9,11], Little is known about how these antibodies are induced. They may be true autoantibodies induced by autologous structures that become exposed after cell destruction in infections.…”

mentioning

confidence: 99%

Effective Inhibition of Cardiolipin‐Binding Antibodies in Gram‐Negative Infections by Bacterial Lipopolysaccharide

1988

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Anticardiolipin antibodies (ACA) were detected by solid-phase enzyme immunoassay in the majority of sera from patients with Gram-positive and Gram-negative bacterial infections. The response involved all the major immunoglobulin classes IgG, IgM, and IgA. The specificity of the ACA was studied in competitive inhibition experiments with three putative antigens: cardiolipin, lipopolysaccharide (LPS) isolated from Salmonella minnesota, strain Re 595, and synthetic Escherichia coli lipid A. The binding of IgG class ACA from the sera of five patients with Gram-negative infections was effectively inhibited by LPS, whereas 100-fold more cardiolipin was required for comparable inhibition. Pure lipid A was a less effective inhibitor of anticardiolipin activity than LPS. This pattern of reactivity was not seen in sera from patients with Gram-positive infections, syphilis, or systemic lupus erythematosus. Our findings suggest that cardiolipin may not be the inducing antigen for the cardiolipin-binding antibodies that develop in Gram-negative infections.

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confidence: 99%

Effective Inhibition of Cardiolipin‐Binding Antibodies in Gram‐Negative Infections by Bacterial Lipopolysaccharide

1988

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The Future of the N. E. A.

Cited by 1 publication

References 0 publications

Effective Inhibition of Cardiolipin‐Binding Antibodies in Gram‐Negative Infections by Bacterial Lipopolysaccharide

Effective Inhibition of Cardiolipin‐Binding Antibodies in Gram‐Negative Infections by Bacterial Lipopolysaccharide

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