The garlic-derived organosulfur compound diallyl trisulphide suppresses tissue factor function

Okue, Sachiko; Yaguchi, Manami; Miura, Asako; Ozaki-Masuzawa, Yori; Hosono, Takashi; Seki, Taiichiro

doi:10.1039/d1fo02206g

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…Therefore, inhibition of the JNK pathway by DATS may inhibit the induction of TF by TNF-α. DATS inhibited not only TF activity but also TF mRNA and protein expression in vitro ( Okue et al, 2022 ). Garlic is a promising food with anti-thrombotic function, which can suppress both primary and secondary clot formation.…”

Section: The Pharmacological Activity Of Garlicmentioning

confidence: 99%

Roles and mechanisms of garlic and its extracts on atherosclerosis: A review

Yun

Wang

et al. 2022

Front. Pharmacol.

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The prevention and treatment of cardiovascular diseases (CVDs) have achieved initial results, but the number of CVDs patients will increase rapidly in the next 10 years. Atherosclerosis (AS) is a significant risk factor for CVDs. The impact of lifestyle and daily diet varies considerably between different countries and continents and has been shown to affect the development of various diseases such as diabetes and CVDs. Primary and secondary prevention using alternative supplements and methods to avoid or reduce the use of traditional pharmacological drugs have also become popular. One of the reasons for this is that pharmacological drugs with lipid-lowering, and blood pressure-lowering effects cause many side effects that may negatively impact the quality of life. Patients are now emphasizing reliance on lifestyle changes to reduce cardiovascular risks. Garlic is a medicinal and edible plant that has been used for a long time. In order to reveal garlic application in the prevention and treatment of AS, reviewing the latest domestic and international studies through searching databases. The result shows that the antiatherogenic role of garlic is eximious. And the mechanisms are mainly related to hypolipidemic, antioxidant, antithrombotic, inhibiting angiogenesis, protecting endothelial cells, anti-inflammatory, anti-apoptotic, inhibiting vascular smooth muscle proliferation, and regulating gut microbiota. The main signaling pathways involve AMPK/TLRs, Keap1/Nrf2, PI3K/AKT, PPARγ/LXRα, GEF-H1/RhoA/Rac, etc. The antiatherogenic actions and molecular mechanism of garlic were reviewed in this study to obtain a robust evidence basis for the clinical application and mechanistic study and provide a theoretical basis for further utilization of garlic.

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Section: The Pharmacological Activity Of Garlicmentioning

confidence: 99%

Roles and mechanisms of garlic and its extracts on atherosclerosis: A review

Yun

Wang

et al. 2022

Front. Pharmacol.

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“…16 DATS administration in mice tended to decrease the atherosclerotic lesion size and suggested a poss-ible inhibition of plaque formation. 17 In addition, 2VD inhibits human preadipocyte differentiation and has anti-inflammatory properties. 18 All of the above allow us to test the hypothesis whether supplementation with OMG to the regular diet of adult ApoE-KO mice would prevent the increase in systemic oxidative stress and inflammation usually developed in these animals, protecting from oxidative/inflammatory injury at the vascular and kidney levels.…”

Section: Introductionmentioning

confidence: 99%