The GATA family (vertebrates and invertebrates)

Patient, Roger; McGhee, James D.

doi:10.1016/s0959-437x(02)00319-2

Cited by 501 publications

(395 citation statements)

References 51 publications

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“…GATA proteins are transcription factors, which regulate diverse processes during embryogenesis and in adults (Patient and McGhee, 2002). The GATA4, 5, and 6 genes are all important in vertebrates for endoderm formation (Weber et al, 2000;Afouda et al, 2005) and are central regulators of heart development (Gove et al, 1997;Reiter et al, 1999;Peterkin et al, 2003Peterkin et al, , 2007Holtzinger and Evans, 2005;Afouda et al, 2008;Haworth et al, 2008;Takeuchi and Bruneau, 2009).…”

Section: Introductionmentioning

confidence: 99%

Different requirements for GATA factors in cardiogenesis are mediated by non‐canonical Wnt signaling

Afouda¹,

Hoppler²

2011

Developmental Dynamics

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GATA factors and Wnt signals are key regulators of vertebrate cardiogenesis, but specific roles for individual GATA factors and how they interact with Wnt signaling remain unknown. We use loss of function and overexpression approaches to elucidate how these molecules regulate early cardiogenesis in Xenopus. In order to minimize indirect effects due to abnormal early embryogenesis, we use pluripotent embryonic tissues as cardiogenic assays. We confirm central roles for GATA4, 5, and 6 in cardiogenesis, but also discover individual and different requirements. We show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation. We also show that Wnt11b signaling can rescue reduced cardiac differentiation resulting from loss of function of GATA4 and 6 but not GATA5. We conclude that Wnt11b mediates the differential requirements for GATA factors during vertebrate cardiogenesis. Developmental Dynamics 240:649-662,

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Section: Introductionmentioning

confidence: 99%

Different requirements for GATA factors in cardiogenesis are mediated by non‐canonical Wnt signaling

Afouda¹,

Hoppler²

2011

Developmental Dynamics

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“…7 GATA4, 5 and 6 are expressed early in the heart tissue and endodermal derivatives. 7,8 Of these three GATA transcription factors, GATA4 has been most extensively studied and is thought to have a dominant role in heart development. 9 Numerous mutations in GATA4 have been recognized in a wide range of cases, including tetralogy of Fallot (TOF), pulmonary stenosis, atrial septal defects (ASDs), ventricular septal defects, atrioventricular septal defects and patent ductus arteriosus.…”

Section: Introductionmentioning

confidence: 99%

A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect

et al. 2010

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GATA6 is a member of the GATA family of transcription factors, and its expression and functions overlap with those of GATA4 during heart development. Mutations in GATA4 have been related to human congenital heart diseases (CHDs) in several studies, whereas mutations in GATA6 have only recently been reported in patients with persistent truncus arteriosus. Animal experiments have revealed critical roles for GATA6 in the development of the myocardium and cardiac morphogenesis, thereby highlighting the potential involvement of GATA6 defects in the pathogenesis of CHDs. Here, we screened the GATA6 in 270 individuals with sporadic CHDs by direct sequencing. After identification of the mutation, a luciferase reporter assay and real-time quantitative polymerase chain reaction were performed to detect functional changes in the mutant transcription factor. The same heterozygous missense mutation (Ser184Asn) was identified in three patients, including one with tetralogy of Fallot and two with atrial septal defects. This mutation was not found in 500 unrelated ethnically matched healthy subjects. Direct sequencing of this region in the parents of these three patients revealed the same mutation in one of the parents for each patient, and one of the parent carriers presented with a bicuspid aortic valve. Biological analysis revealed clearly decreased transcriptional activity of GATA6 Ser184Asn in vitro. All these data suggest that GATA6 Ser184Asn is a novel mutation associated with CHDs and has an important role in disease pathogenesis.

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“…GATA3 is located at chromosome 10p15 [2]. GATA 1, 2 and 3 are critically involved in myeloerythropoiesis whereas GATA 4, 5 and 6 are implicated in cardiac and intestinal development [3]. The binding element comprises two C4 zinc finger motifs shared with the steroid hormone receptor super family, and is highly conserved among different vertebrate and invertebrate species [1].…”

Section: Introductionmentioning

confidence: 99%

The significance of GATA3 expression in breast cancer: a 10-year follow-up study

Ciocca¹,

Daskalakis²,

Ciocca³

et al. 2009

Human Pathology

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The GATA family (vertebrates and invertebrates)

Cited by 501 publications

References 51 publications

Different requirements for GATA factors in cardiogenesis are mediated by non‐canonical Wnt signaling

Different requirements for GATA factors in cardiogenesis are mediated by non‐canonical Wnt signaling

A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect

The significance of GATA3 expression in breast cancer: a 10-year follow-up study

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