The gel generator: a viable alternative source of 99mTc for nuclear medicine

Boyd, R.E.

doi:10.1016/s0969-8043(96)00298-9

Cited by 43 publications

(27 citation statements)

References 2 publications

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“…It can be seen from Table 2 that the chemical yield of 99m Tc was 71-75 % based on the 10 and 15 MeV bremsstrahlung irradiation. The ZrMo gel generator has been established as an alternative user friendly column source to obtain 99m Tc from low specific activity 99 Mo [37][38][39]. The 99m Tc-elution performance of the gel is assessed based on the following important factors: the 99m Tc elution efficiency, the 99 Mo breakthrough in the 99m Tc eluate, the gel synthesis conditions such as the molar ratios of zirconium to molybdenum, the drying conditions i.e.…”

Section: Resultsmentioning

confidence: 99%

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Gopalakrishna¹,

Naik

Suryanarayana

et al. 2015

J Radioanal Nucl Chem

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The radionuclide 99 Mo has been prepared by 100 Mo(c, n) reaction using two types of natural molybdenum compound (molybdenum trioxide and zirconium molybdate gel) with the bremsstrahlung end-point energies of 10 and 15 MeV. After the equilibrium, 99m Tc was separated as NaTcO 4 from the irradiated samples using two different chemical procedures to examine the chemical yield. The separated Na[ 99m Tc]TcO 4 from the ZrMo gel has the 99Mo breakthrough of \10 -4 %, radiochemical purity[99 % as well as chemical impurities of Al, Mo and Zr \ 10 ppm. The estimation of 99 Mo and 99m Tc was done by using off-line c-ray spectrometric technique. The chemical yield of the separated 99m Tc from the dissolved molybdenum trioxide is 70.7-75.2 %, whereas in the undissolved zirconium molybdate gel, it is 19.1-43 %. The second method is preferable because it is user friendly in hospital radiopharmacy throughout the shelf-life.Keywords Medical isotope 99 Mo-9m Tc Á 100 Mo(c,n) reaction Á Molybdenum trioxide Á Zirconium molybdate gel Á Off-line c-ray spectrometric technique Á Chemical yield

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Section: Resultsmentioning

confidence: 99%

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Gopalakrishna¹,

Naik

Suryanarayana

et al. 2015

J Radioanal Nucl Chem

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“…The post-irradiation process is only dissolution of the irradiated solid targets with an alkaline solution, and only a small amount of radioactive waste is generated in the process compared with the (n, f) method. The 99 Mo production cost of this method or the (n, γ) method is only 0.83 US$/37 GBq (Boyd, 1997).…”

Section: Solid Irradiation Methodsmentioning

confidence: 97%

“…Caused by the radioactive waste, the separation process of 99 Mo is too complex, and 99 Mo production with the (n, f) method needs expensive facilities and extreme care to avoid contamination with FPs. The 99 Mo production cost by this method achieves 57 US$/37 GBq (Boyd, 1997), and it is too expensive.…”

Section: Fission Methods ((N F) Method)mentioning

confidence: 99%

Development of 99Mo Production Technology with Solution Irradiation Method

Inaba¹

2012

Nuclear Reactors

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“…Furthermore, some gel and distillation generators have been developed [cf . 8,9] but their overall efficiencies are not comparable to that of the alumina column generator. In view of the situation, combined with the fact that for production purposes irradiations are mostly done at medium-flux reactors, the method of choice for production of 99 Mo for medical use is the fission process.…”

Section: Gamma Emitters For Spectmentioning

confidence: 94%

The present and future of medical radionuclide production

Qaim

2012

Radiochimica Acta

103

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Reactor and cyclotron production of medical radionuclides / γ -ray emitters for SPECT / Positron emitters for PET / Corpuscular radiation emitters for internal radiotherapy / Low and intermediate energy nuclear reactions / Radionuclide generators / Future directionsSummary. Medical radionuclide production technology is well established. Both reactors and cyclotrons are utilized for production; the positron emitters, however, are produced exclusively using cyclotrons. A brief survey of the production methods of most commonly used diagnostic and therapeutic radionuclides is given. The emerging radionuclides are considered in more detail. They comprise novel positron emitters and therapeutic radionuclides emitting low-range electrons and α-particles. The possible alternative production routes of a few established radionuclides, like 68 Ga and 99m Tc, are discussed. The status of standardisation of production data of the commonly used as well as of some emerging radionuclides is briefly mentioned. Some notions on anticipated future trends in the production and application of radionuclides are considered.

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The gel generator: a viable alternative source of 99mTc for nuclear medicine

Cited by 43 publications

References 2 publications

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Development of 99Mo Production Technology with Solution Irradiation Method

The present and future of medical radionuclide production

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