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The technetium-99m generator has experienced many improvements and changes since it was introduced to nuclear medicine in the late 1950 s. In the industrialized countries of the world, the. most common form in use today is the chromatographic generator, based on fission molybdenum-99. This presents significant problems to the less industrialized countries and to overcome these much research is under way searching for viable alternatives. Improvements have been made to techniques for generating technetium-99m by MEK extraction and sublimation. A new technology, based on the separation of technetium-99m from an insoluble gel containing (η,γ) molybdenum-99, introduces exciting prospects which promise all the advantages currently enjoyed only by the fission-molybdenum-99 generator without any of the concomitant problems of complex processing, pollution and the need to dispose of high activity wastes. The paper addresses a number of these developments which are seen as signposts to the future.

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