The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13).

Abstract

A clone that cross-hybridizes with a mouse p53 probe has been isolated from a cDNA library of simian virus 40-transformed human fibroblasts. This cloned human p53 cDNA was used as a probe to examine DNAs obtained from human-rodent somatic cell hybrids that have segregated human chromosomes. The results show that the human p53 gene is located on chromosome 17. In addition, Southern analysis of hybrids prepared from human cells containing a chromosome 17 translocation allowed regional localization of the human p53 gene to the most distal band on the short arm of this chromosome (17p13). Localization of the p53 gene to 17pl3 was confirmed by in situ hybridization of metaphase spreads with the human p53 probe.

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

“…For example, the amplification expression of mir-17, mir-21 and mir-155 relatively cause tumour initiation and progression by inhibiting the expression of tumour suppressor genes, such as phosphatase and tensin homologue (PTEN), and programmed cell death 4 (PDCD4) (Meng et al, 2007;Petrocca et al, 2008;Frankel et al, 2008). In contrast, p53, also known as tumour protein 53, and is a tumour protein that in humans is encoded by the TP53 gene (McBride et al, 1986), is the most important and well-studied cancer gene that regulates the cell cycle involved in preventing cancer. Fundamentally, the action of p53 is to induce the expression of miRNAs, best described by the miR-34 family, which represses genes that can promote proliferation and apoptosis (He et al, 2007).…”

Duplication polymorphism within the third intron of thep53 gene is a rare event in Japanese population

“…One of the tumor suppressor genes, human p53 gene has been assigned to 17p13.1 (Isobe et al, 1986;McBride et al, 1986) and its molecular abnormalities were frequently found in various tumor cells. The sequence polymorphisms within tumor suppressor genes are useful for the detection of loss of allele, and also it is important to be aware of rare sequence polymorphisms in the screening for gene mutations.…”

Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma.

“…The p53 tumor suppressor gene, located on the short arm of human chromosome 17 (1,2), encodes a 53-kd nuclear phos-phoprotein that functions as a negative regulator of cell proliferation (3,4). p53 is a transcription activating factor that acts as a "checkpoint" control late in GI to block the progression of cells through the cell cycle, particularly in the presence of DNA damage (5)(6)(7)(8)(9).…”