The gene map of the rabbit (&lt;i&gt;Oryctolagus cuniculus&lt;/i&gt; L.)

Echard, G.; Gellin, Joël; Benne, F.; Gillois, M.

doi:10.1159/000131566

Cited by 9 publications

(1 citation statement)

References 6 publications

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“…Such a release from selective confinements of chromosome association might also explain the extreme chromosomal variations within certain groups such as the Canidae (order Carnivora). The species of Canidae vary continuously in chromosome number from a minimum of 36 metacentric and submetacentric chromosomes in the red fox (Vulpes vulpes) to a maximum of 72 acrocentric and telocentric chromosomes in the domestic dog (Canisfamiliaris) (12,38,39). A more apparent example would be the well-known case of the genus Muntiacus in which one species, the Chinese muntjac (M. reevesi), has a diploid number of46, while a second species, the Indian munqtac (M. muntjac), has a diploid number of6 in females and…”

Section: Discussionmentioning

confidence: 99%

Conserved regions of homologous G-banded chromosomes between orders in mammalian evolution: carnivores and primates.

Nash¹,

O’Brien²

1982

Proc. Natl. Acad. Sci. U.S.A.

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The recent derivation ofa biochemical map of33 loci of the domestic cat (Felis cattu) revealed a striking conservation of chromosomal linkage associations between the cat and humans. A comparison of homologous (by linkage criteria) chromosomes by using conventionally extended and high-resolution Gbanding of human and feline chromosomes is presented. Four criteria for establishing probable cytogenetic homologies of chromosomal regions were invoked: (i) map placement of homologous genes to the same chromosomes; (ii) cytological correlation of Gbanding pattern; (iii) placement of homologous genes, by regional gene mapping, in the region of cytological homology; and (iv) a requirement that the putative region of homology be ancestral and evolutionarily conserved within their respective orders. Five subchromosomal regions (homologous to human chromosome ip, 2p, 2q, 12, and X) were found to be conserved and homologous by all the stated criteria. The conserved regions constitute nearly 20% by length of the human chromosomal genome. The implications of conservation of chromosome homologies between mammalian orders whose last common ancestor became extinct more than 60 million years ago is discussed.The increasing application ofchromosome banding methods to cytogenetic studies of mammalian chromosomes has made it possible to monitor more accurately the divergence of chromosome structure over tens of millions of years of mammalian evolution (1)(2)(3). By using the pattern of banding as a guide, homologous regions in the chromosomes of two species can often be identified even when the overall morphologies of the chromosomes are quite different. While the chromosomes of nearly all major mammalian taxa have been investigated with modern banding procedures, phylogenetic chromosome relationships have been extensively studied in the primates and carnivores with particular attention to the Felidae family (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).The elegant analyses of primate phylogenies presented by Dutrillaux and co-workers have established the feasibility of tracking the cytogenetic rearrangements that have occurred during the development of the primate order (1,(4)(5)(6)(7)(8)(9)(10). More recent studies using high-resolution banding techniques have shown that extensive chromosome banding homology exists not only between closely related primates (e.g., human, chimpanzee, gorilla, and orangutan) but also to a lesser extent between distantly related primates such as man and woolly monkey or lemur (6,7,9). Comparative cytological analyses of more than 70 extant primate species has permitted the reconstruction of more than 150 chromosome rearrangements (robertsonian translocations, paracentric and pericentric inversions, acrocentric fusions, and metacentric chromosome fissions) that presumably occurred during the 60-80 million years of primate evolution. The chromosome homologies have been further extended in the primates by comparative gene mapping of homologous enzyme structural genes using somatic cell hybrids...

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Section: Discussionmentioning

confidence: 99%