The Genetics of Disorders Affecting the Premature Newborn

Prosnitz, Aaron R.; Gruen, Jeffrey R.; Bhandari, Vineet

doi:10.1016/b978-0-12-383834-6.00171-3

Cited by 4 publications

(2 citation statements)

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“…Interferon gamma (IFNγ) is a pro-inflammatory cytokine that primarily activates macrophages and stimulates neutrophils [ 37 ]. Signal transducer and activator of transcription 1 (Stat1) increases macrophage inflammatory responses [ 38 ] and is one of the primary transcription factors activated by IFNγ, thus playing a major role in immune responses [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period

Hedley,

Gomez,

Kecelioglu

et al. 2024

J Neuroinflammation

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Respiratory infections are one of the most common causes of illness and morbidity in neonates worldwide. In the acute phase infections are known to cause wide-spread peripheral inflammation. However, the inflammatory consequences to the critical neural control centres for respiration have not been explored. Utilising a well characterised model of neonatal respiratory infection, we investigated acute responses within the medulla oblongata which contains key respiratory regions. Neonatal mice were intranasally inoculated within 24 h of birth, with either Chlamydia muridarum or sham-infected, and tissue collected on postnatal day 15, the peak of peripheral inflammation. A key finding of this study is that, while the periphery appeared to show no sex-specific effects of a neonatal respiratory infection, sex had a significant impact on the inflammatory response of the medulla oblongata. There was a distinct sex-specific response in the medulla coincident with peak of peripheral inflammation, with females demonstrating an upregulation of anti-inflammatory cytokines and males showing very few changes. Microglia also demonstrated sex-specificity with the morphology of females and males differing based upon the nuclei. Astrocytes showed limited changes during the acute response to neonatal infection. These data highlight the strong sex-specific impact of a respiratory infection can have on the medulla in the acute inflammatory phase.

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Section: Resultsmentioning

confidence: 99%

Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period

Hedley,

Gomez,

Kecelioglu

et al. 2024

J Neuroinflammation

View full text Add to dashboard Cite

show abstract

“…Genomic variants predisposing to BPD may be single nucleotide polymorphisms (SNPs), which may increase susceptibility to the disease. Candidate gene variants associated with BPD have been reviewed recently 12 , 13 and will not be discussed in detail in this manuscript.…”

Section: Genomics Of Bpdmentioning

confidence: 99%