The genetics of gestational trophoblastic disease: a rare complication of pregnancy

Hoffner, Lori; Surti, Urvashi

doi:10.1016/j.cancergen.2012.01.004

Cited by 73 publications

(72 citation statements)

References 148 publications

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“…Eight cases of CHMCF after ICSI were reported in literature [19] . The possibility of dispermic fertilization should be reduced when ICSI has been employed, but only about 20% of CHM results from dispermic fertilization [20] . Bruchim et al [21] speculated that forced ovulation of more than one egg by ovulation inducing agent might increase the rate of a nuclear 'empty' egg supporting development of a CHM.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Twin Pregnancies with Complete Hydatidiform Mole and Coexistent Normal Fetus: A Series of 13 Cases

Giorgione

Cavoretto

Cormio

et al. 2016

Gynecol Obstet Invest

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Aim: The study aimed to describe prenatal diagnosis and the outcome of complete hydatidiform mole and coexistent normal fetus (CHMCF). Methods: This was a retrospective case series of 13 patients with CHMCF. Prenatal diagnosis, outcome and development of gestational trophoblastic neoplasia (GTN) were reviewed. Results: Ultrasound diagnosis was carried out in 12 of 13 cases at 17 ± 2.7 weeks of gestation (mean ± SD). Six patients showed abnormalities suggestive of subchorionic hematoma on first trimester ultrasonography (US). Prenatal invasive procedures were performed in 8 of 13 cases (62%). Two women decided to terminate their pregnancies. Four ended in late miscarriages (36%, 4 of 11) between 13 and 21 weeks, and early neonatal death occurred in 1 case (9%, 1 of 11); 5 women delivered a live baby with a mean gestational age of 31 weeks (range 26-37 weeks) with an overall neonatal survival of 45% (5 of 11). GTN occurred in 31% of cases (4 of 13). Conclusions: The first trimester US features of CHMCF are not well-documented. Our series showed that abnormalities of CHMCF could be misdiagnosed as subchorionic hematoma in the early first trimester. When CHMCF is confirmed by expert US, prenatal invasive procedures should be carefully evaluated depending on the associated US findings and exhaustive counseling should be performed.

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Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Twin Pregnancies with Complete Hydatidiform Mole and Coexistent Normal Fetus: A Series of 13 Cases

Giorgione

Cavoretto

Cormio

et al. 2016

Gynecol Obstet Invest

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“…Há vasos contendo hemácias nucleadas, fetais, a indicar existência de concepto, ainda que seus remanescentes não possam ser evidenciados pela consequente degeneração do embrião. 14 …”

Section: Patologiaunclassified

Doença trofoblástica gestacional

Braga

Obeica

Moraes

et al. 2014

Revista Hospital Universitário Pedro Ernesto

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ResumoDoença trofoblástica gestacional é anomalia de gravidez que engloba formas clínicas benignas (mola hidatiforme completa e parcial) e malignas (mola invasora, coriocarcinoma, tumor trofoblástico do sítio placentário e tumor trofoblástico epitelioide). Sua forma mais comum, a mola hidatiforme, acomete 1:200 grávidas brasileiras. No passado era comum a paciente com mola hidatiforme apresentasse sintomatologia exuberante: hemorragia copiosa, cistos teca-luteínicos dos ovários, útero aumentado para a idade gestacional, pré-eclâmpsia precoce, hiperemese e hipertireoidismo. Hoje, com o diagnóstico precoce feito pela ultrassonografia, muitas pacientes são diagnosticadas com gestação molar ainda em fase assintomática. Todavia, este diagnóstico precoce tem dificultado a análise histopatológica do material molar, tornando as técnicas imuno-histoquímica e de biologia molecular importantes para a confirmação diagnóstica. Por seu potencial de evoluir para neoplasia trofoblástica gestacional, as pacientes acometidas por gravidez molar devem ser atendidas em Centros de Referência, onde são inicialmente submetidas ao esvaziamento uterino pela técnica de vácuo-aspiração. Nestes serviços especializados, elas também terão monitorados seus níveis de gonadotrofina coriônica humana a fim de detectar precocemente a persistência da doença e sua progressão maligna. Vale salientar que o uso rigoroso de contracepção hormonal é fundamental para manter fidedigno o marcador tumoral dessa doença. Espera-se que cerca de 20% das pacientes com mola hidatiforme evolvam para neoplasia trofoblástica, cujo tratamento quimioterápico é capaz de curar a grande maioria das pacientes, preservando sua capacidade reprodutiva que, pelo geral, não se altera. O objetivo desse artigo é rever aspectos clínicos, genéticos, patológicos e terapêuticos da doença trofoblástica gestacional, importante causa de hemorragia da gestação.Descritores: Mola hidatiforme; Gonadotrofina Coriônica Humana; Contracepção. AbstractGestational trophoblastic disease is disorder of pregnancy that encompasses clinical benign forms (complete and partial hydatidiform mole) and malignant forms (invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor). Its most common form, hydatidiform mole, affects 1:200 pregnant in Brazil. In the past it was common for a patient with hydatidiform mole present exuberant symptoms: copious bleeding, theca lutein cysts of the ovary, enlarged uterus for gestational age, early preeclampsia, hyperemesis and hyperthyroidism. Nowadays, with early diagnosis made by ultrasound, many patients are still diagnosed asymptomatic. However, this situation has hindered early diagnosis histopathological analysis of molecular material, making immunohistochemistry and molecular biology major in the diagnostic. For its potential to develop into gestational trophoblastic neoplasia, patients affected by molar pregnancy should be followed in the Reference Centers, where they are initially subjected to uterine vacuum aspiration ...

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“…Choriocarcinoma is characterized by trophoblastic tissue invading the myometrium and potentially metastasizing through the uterine blood vessels to the rest of the body. Choriocarcinoma is rare in domestic animals and occurs in approximately 1 in 20 000 to 40 000 human pregnancies (Hoffner & Surti 2012, Monchek & Wiedaseck 2012. Gestational chorio carcinoma occurs when the neoplasm is derived from pregnancies, induced or spontaneous abortions, ectopic pregnancies, and term or preterm deliveries (Hoffner & Surti 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Choriocarcinoma is rare in domestic animals and occurs in approximately 1 in 20 000 to 40 000 human pregnancies (Hoffner & Surti 2012, Monchek & Wiedaseck 2012. Gestational chorio carcinoma occurs when the neoplasm is derived from pregnancies, induced or spontaneous abortions, ectopic pregnancies, and term or preterm deliveries (Hoffner & Surti 2012). Latent choriocarcinoma has appeared years after the last known pregnancy (Dehner 1980).…”

Section: Introductionmentioning

confidence: 99%

“…Symptoms may include abnormal bleeding for more than 6 wk following a pregnancy or may be more subtle. Monitoring blood serum levels of human chorionic gonadotropin, which is produced by all gestational trophoblastic tumors, can aid in diagnosis of this type of neoplasm (Hoffner & Surti 2012). This hormone generally increases or plateaus at an abnormally high levels (Soper et al 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ectopic pregnancy with associated gestational choriocarcinoma in a California sea lion (Zalophus californianus)

Fravel¹,

Lowenstine²,

Koehne³

2016

Dis. Aquat. Org.

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The genetics of gestational trophoblastic disease: a rare complication of pregnancy

Cited by 73 publications

References 148 publications

Prenatal Diagnosis of Twin Pregnancies with Complete Hydatidiform Mole and Coexistent Normal Fetus: A Series of 13 Cases

Prenatal Diagnosis of Twin Pregnancies with Complete Hydatidiform Mole and Coexistent Normal Fetus: A Series of 13 Cases

Doença trofoblástica gestacional

Ectopic pregnancy with associated gestational choriocarcinoma in a California sea lion (Zalophus californianus)

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