The Genetics of Impulsivity: A Synthesis of Findings in Humans and Rodent Models

Jupp, Bianca; Dalley, Jeffrey W.

doi:10.1007/978-1-4939-3777-6_3

Cited by 2 publications

(1 citation statement)

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“…Activities in the frontostriatal networks mentioned above is modulated by the ascending monoaminergic systems [ 92 , 93 ], specifically dopamine from the ventral tegmental area [ 94 ], serotonin from the dorsal and medial raphe nuclei [ 95 ], and noradrenaline from the locus coeruleus [ 96 ]. It should also be noted that non-monoaminergic transmission including GABA, glutamate, and endogenous opioids also modulate trait impulsivity [ 97 ]; however such systems are outside the scope of this review.…”

Section: Neurobiology Of Trait Impulsivity In Pdmentioning

confidence: 99%

Trait Impulsivity as a Feature of Parkinson’s Disease Treatment and Progression

Spencer,

Anderton

2024

Parkinson's Disease

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Heightened trait impulsivity in both subclinical and pathological senses is becoming increasingly recognised in Parkinson’s disease (PD). Impulsive behaviours and impulse control disorders (ICDs) are a consequence of perturbation to the rewards pathway leading individuals to conduct activities in a repetitive, excessive, and maladaptive fashion. Commonly linked to PD, heightened trait impulsivity has been found to primarily manifest in the forms of hypersexuality, pathological gambling, compulsive shopping, and binge eating, all of which may significantly impact social and financial standing. Subsequent burden to quality of life for both individuals with PD and caregivers are common. Although risk factors and indicators for ICDs in PD are currently lacking, it is recognised that the condition is often precipitated by dopamine replacement therapies, primarily dopamine agonist administration. While this nonmotor symptom is being increasingly diagnosed in PD populations, it remains relatively elusive in comparison to its motor counterparts. Through discussion of impulsivity characteristics, neuroanatomy, and neurochemistry, in addition to reviewing existing research on the potential contributing factors to impulsivity in PD, this review highlights impulsivity as a significant and detrimental PD symptom. Thus, emphasising the imperative need to establish efficacious diagnostic tools and treatments.

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Section: Neurobiology Of Trait Impulsivity In Pdmentioning

confidence: 99%

Trait Impulsivity as a Feature of Parkinson’s Disease Treatment and Progression

Spencer,

Anderton

2024

Parkinson's Disease

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Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1

Jupp

Pitzoi

Petretto

et al. 2020

Sci Rep

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Differential gene expression within the identified linkage region in highly-impulsive rats. To identify potential candidate genes within the linkage region we conducted a microarray analysis to investigate differences in transcript levels between HI and LI from both the outbred base population and animals from the sixth generation of the pedigree to identify common alterations in transcriptome expression associated with impulsivity. We investigated transcript expression in the NAcC, NAcS and in the case of sixth generation rats, the ventromedial PFC, or infralimbic cortex (IL) (Fig. 4A). Of the 148 genes within the linkage region represented on the array (Supplementary Table S5), several of these genes were found to be differentially-regulated in HI and LI rats (false discovery rate 10%) based on a non-parametric ranking analysis of the microarray data. A total of 13 transcripts were found to be up-regulated and 16 down-regulated in HI rats of the outbred base population, while 6 transcripts were up-regulated and 7 down-regulated in the F6 generation of HI rats (Table 2). Of these differentially-expressed transcripts, two were found to be consistently differentially-regulated in the same direction, in the same brain region between the two generations examined, Hbb and Nmb (Fig. 4B). After integration of the differential expression findings with the WGS results, we found that some of the differentially-expressed genes were also polymorphic (Pde3b, Sv2b, and Hbb; Supplementary Table S3) or had indels (Sv2b,

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The Genetics of Impulsivity: A Synthesis of Findings in Humans and Rodent Models

Cited by 2 publications

References 281 publications

Trait Impulsivity as a Feature of Parkinson’s Disease Treatment and Progression

Trait Impulsivity as a Feature of Parkinson’s Disease Treatment and Progression

Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1

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