Over the past decade, a growing interest in the possibility that biological factors, including genes, might contribute to individual differences in political and social behaviors has emerged. Behavioral genetic techniques have provided a variety of approaches to quantify the effects of genetic and nongenetic inheritance. However, until quite recently, these methods were largely unknown to political scientists. In this essay, we review the general approaches to modeling genetic and social influences on differences in complex human social traits. In so doing, we focus on the “genetics of politics,” including attitudes, ideologies, voting, and partisanship. The emergence of this research reflects a paradigm shift in the study of social traits necessitating the inclusion of biological influences, and recognizing the interdependence of genetic, social, and environmental factors in the development of political behaviors over the life course.