The genetics of pre-eclampsia and other hypertensive disorders of pregnancy

Williams, Paula; Pipkin, Fiona Broughton

doi:10.1016/j.bpobgyn.2011.02.007

Cited by 215 publications

(181 citation statements)

References 88 publications

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“…These findings could be consistent with a genetic origin of HDP, but while the familial clustering of preeclampsia is well documented,50 there is limited knowledge about a possible genetic basis for the disorder 51. The higher risk of HDP in women who were born prematurely or with low birthweight52 supports that the elevated cardiovascular risk factor levels in women with HDP may be attributed to genes or to adverse in utero conditions 53.…”

Section: Discussionmentioning

confidence: 70%

Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway

Haug

Horn

Markovitz

et al. 2018

JAHA

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BackgroundWomen with hypertensive pregnancy disorders have adverse levels of cardiovascular risk factors. It is unclear how this adverse risk factor profile evolves during adult life. We compared life course trajectories of cardiovascular risk factors in women with preeclampsia or gestational hypertension in their first pregnancy to normotensive women.Methods and ResultsWe linked information on cardiovascular risk factors from the population‐based HUNT (Nord‐Trøndelag Health Study) surveys with pregnancy information from the Medical Birth Registry of Norway. Trajectories of cardiovascular risk factors were constructed for 22 308 women with a normotensive first pregnancy; 1092 with preeclampsia, and 478 with gestational hypertension in first pregnancy. Already before first pregnancy, women with preeclampsia in their first pregnancy had higher measures of adiposity, blood pressure, heart rate, and serum lipids and glucose compared with women with a normotensive first pregnancy. After first pregnancy, there was a parallel development in cardiovascular risk factor levels, but women with a normotensive first pregnancy had a time lag of >10 years compared with the preeclampsia group. There were no clear differences in risk factor trajectories between women with gestational hypertension and women with preeclampsia.ConclusionsWomen with hypertensive pregnancy disorders in their first pregnancy had an adverse cardiovascular risk factor profile before pregnancy compared with normotensive women, and the differences persisted beyond 50 years of age. Hypertensive disorders in pregnancy signal long‐term increases in modifiable cardiovascular risk factors, and may be used to identify women who would benefit from early prevention strategies.

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Section: Discussionmentioning

confidence: 70%

Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway

Haug

Horn

Markovitz

et al. 2018

JAHA

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“…Relationships between Apo E polymorphisms and lipid metabolism have been extensively studied in cardiovascular and neurodegenerative disorders such as Alzheimer disease and Parkinson disease and allele E4 has been implicated as risk factor in these conditions [14]. In normal pregnancy the cholesterol level is naturally increased and as a result Apo E could be involved [15]. On this basis, the present study was designed to investigate frequency of various genotypes of Apo E in two groups of women: a group of RPL patients versus normal controls.…”

Section: Introductionmentioning

confidence: 99%

Positive association of Apolipoprotein E4 polymorphism with recurrent pregnancy loss in Iranian patients

Asgari

Akbari

Zare

et al. 2013

J Assist Reprod Genet

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Problem Numerous lines of evidence implicate Apolipoprotein E (Apo E) in lipid metabolism during pregnancy. Hence, a role for its polymorphism has been envisaged in recurrent pregnancy loss (RPL) considering major structural and functional differences between different Apo E genotypes. Method of study A case control study of 81 women with two or more pregnancy losses that did not have any other known risk factors including anatomic anomalies of the reproductive system, infections, immunologic factors, hormonal imbalances, chromosomal abnormalities and environmental factors was carried out. The control group consisted of 81 women with at least two healthy children and no RPL in their reproductive history. DNA was extracted from the peripheral blood following written consent and Apo E genotyping was carried out by amplifying exon 4 of the gene and subjecting it to digestion by HhaI restriction enzyme. Results Genotyping was concluded by analyzing different fragment sizes produced, which resulted in finding significantly higher frequency of combined E3/E4 and E4/E4 genotypes in the patients (about 20 %) compared to the normal controls (2.4 %). The genotypes were confirmed by DNA sequencing. Conclusion Allelic frequency for E4 was 13.5 % in the patients and only 1 % in the non-RPL group. Our findings confirm and are in line with a number of similar studies carried out on other populations. Therefore, Apo E4 polymorphism seems to be contributing to the thrombophilic risk factors as a background to RPL.

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“…Many theories have been suggested regarding its aetiopathogenesis, which range from genetic predisposition 2 to defective trophoblastic invasion of spiral arterioles 3 . It is a multisystem disorder with a propensity to affect almost all major organ systems of our body.…”

Section: Introductionmentioning

confidence: 99%

Role of Postpartum Curettage in the Control of Hypertension in Severe Preeclampsia

R¹

2017

jmscr

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The genetics of pre-eclampsia and other hypertensive disorders of pregnancy

Cited by 215 publications

References 88 publications

Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway

Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway

Positive association of Apolipoprotein E4 polymorphism with recurrent pregnancy loss in Iranian patients

Role of Postpartum Curettage in the Control of Hypertension in Severe Preeclampsia

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