The genetics of type 2 diabetes

McCarthy, Mark I.; Menzel, Stephan

doi:10.1046/j.1365-2125.2001.00346.x

Cited by 30 publications

(17 citation statements)

References 61 publications

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“…19,20 In the present study 35 patients had a positive family history indicating either one or both the parents had type 2 diabetes which was at one stage or the other transferred from one generation to another. 21 The average duration of diabetes mellitus in the present study was 5.35 years which was seen in collaboration with previous study by Hyun et al where the mean duration was 5.89 years. The mean changes in FPG in group A, B and C during titration phase were 13.27, 16.3 and 18.56 mg/ dl respectively.…”

Section: Discussionsupporting

confidence: 91%

Comparative Evaluation of DPP-IV Inhibitors and other Oral Hypoglycaemic Agents used Either Alone or in Combination with Reference to Glycemic Targets in Patients with Type 2 Diabetes Mellitus

Anjoom¹,

Kamaal²,

Beg³

et al. 2019

IJCMR

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Introduction: This study assumes significance as it compares head on DPP-IV inhibitors along with other oral hypoglycemic agents with respect to glycemic and non-glycemic targets. Study was done to evaluate the DPP-IV inhibitors and other oral hypoglycemic agents (OHA) either alone or in combination, with reference to glycemic targets like fasting plasma glucose (FPG), post prandial glucose (PPG) and glycosylated hemoglobin (HbA 1c) in type 2 diabetes mellitus. Material and Methods: This was an open labelled comparative study and included 90 patients with Type 2 DM. These patients were divided into 3groups: Each group was containing 30 patients i.e. Group A: DPP-IV inhibitors (n= 30); Group B: Oral hypoglycemic agents other than DPP-IV inhibitors (n= 30) and Group C: DPP-IV inhibitors + other oral hypoglycemic agents (n= 30). The patients were given drugs on the basis of physician's discretion, depending upon the glycemic of the patients at the time of presentation. A detailed history regarding age, sex, profession, duration of disease, treatment history, family history and personal history was taken for each patient. After stabilization patients observed at 0 weeks, 6 weeks, 12 weeks and 24 weeks. Results: Mean duration of diabetes was 5.35±0.53 years, and the mean age of onset of diabetes was 46.98±0.91years. There was no significant difference between the study groups with respect to FPG, PPG, and HbA1c levels. The HbA1c showed significant improvement in each group at the end of study period. Conclusion: In summary, this study showed that treatment with sitagliptin, either alone or in combination with other oral hypoglycemic agent led to clinically meaningful reductions in HbA1c, FPG and PPG over a 24 week period. Sitagliptin presents an alternative therapeutic strategy for patients with type 2 diabetes and, in general, showed significant improvements in glycemic control and is well tolerated, particularly with regard to weight change and hypoglycemia.

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Section: Discussionsupporting

confidence: 91%

Comparative Evaluation of DPP-IV Inhibitors and other Oral Hypoglycaemic Agents used Either Alone or in Combination with Reference to Glycemic Targets in Patients with Type 2 Diabetes Mellitus

Anjoom¹,

Kamaal²,

Beg³

et al. 2019

IJCMR

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“…It has a strong polygenic background on which environmental factors act and to a large extent determine the clinical presentation [2][3][4]. Overt T2DM is usually preceded by and/or associated with the MS (metabolic syndrome), which usually develops because of an excess intake of calories and a sedentary lifestyle, and is characterized by visceral obesity, insulin resistance, hyperinsulinaemia, hypertension, atherogenic dyslipidaemia [high triacylglycerols (triglycerides), low HDL (high-density lipoprotein) and an increase in smalldense LDL (low-density lipoprotein)] and a prothrombotic state [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Size of myocardial infarction induced by ischaemia/reperfusion is unaltered in rats with metabolic syndrome

et al. 2006

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Obesity is associated with metabolic syndrome and increased incidence of and mortality from myocardial infarction. The aim of the present study was to develop an animal model with metabolic syndrome and examine how that influences size of myocardial infarcts induced by occlusion and reperfusion of the left anterior descending coronary artery. Sprague-Dawley rats (n = 105) were fed either LF (low-fat) or MHF (moderately high-fat) diets for 13 weeks before coronary occlusion for 45 min, followed by reperfusion for 60 min. Compared with LF-fed and lean MHF-fed rats, obese MHF-fed rats developed metabolic disturbances similar to those seen in the metabolic syndrome, including being overweight by 24% (compared with lean MHF-fed rats), having 74% more visceral fat (compared with LF-fed rats), 15% higher blood pressure (compared with LF-fed rats), 116% higher plasma insulin (compared with lean MHF-fed rats), 10% higher fasting plasma glucose (compared with LF-fed rats), 35% higher non-fasting plasma glucose (compared with lean MHF-fed rats), 36% higher plasma leptin (compared with lean MHF-fed rats) and a tendency to lower plasma adiponectin and higher plasma non-esterified fatty acids. Infarct size was similar in the three groups of rats (36+/-14, 42+/-18 and 41+/-14% in obese MHF-fed, lean MHF-fed and LF-fed rats respectively). In conclusion, rats fed a MHF diet developed metabolic syndrome, but this did not influence myocardial infarct size.

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“…1 Pada awitan penyakit, T2DM tidak menunjukkan gejala apa pun. 3 Saat terdiagnosis, pasien T2DM seringkali datang dengan satu atau lebih komplikasi kronik. 3 Oleh karena itu, deteksi dini dan pencegahan sangat penting untuk mengurangi mortalitas dan morbiditas yang berkaitan dengan T2DM.…”

Section: Pendahuluanunclassified

“…3 Saat terdiagnosis, pasien T2DM seringkali datang dengan satu atau lebih komplikasi kronik. 3 Oleh karena itu, deteksi dini dan pencegahan sangat penting untuk mengurangi mortalitas dan morbiditas yang berkaitan dengan T2DM. 4 Bagi orang yang berisiko terhadap T2DM, upaya pencegahan terdiri dari kontrol berat badan, aktivitas fisik, diet yang sehat, dan tata laksana farmakologis bila perlu.…”

Section: Pendahuluanunclassified

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Peran Riwayat Ayah Diabetes Melitus Tipe 2 pada Status Prediabetes Anak Kandung Penderita Diabetes Melitus Tipe 2

Ekaputri

Citrawijaya

Adhimulia

et al. 2020

JPDI

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Pendahuluan. Pasien diabetes melitus tipe 2 (DMT2) pada umumnya memiliki satu atau lebih komplikasi kronik pada saat terdiagnosis. Deteksi dini dan pencegahan sangat penting untuk mengurangi angka mortalitas dan morbiditas terkait DMT2, terutama pada kelompok dengan risiko tinggi seperti anak penderita DMT2. Studi ini bertujuan untuk mencari faktor-faktor yang berkaitan dengan status prediabetes pada anak dari penderita diabetes melitus tipe 2.Metode. Studi ini merupakan studi potong lintang yang melibatkan 54 anak dari penderita DMT2. Subjek dikumpulkan secara konsekutif. Status prediabetes ditentukan melalui HbA1C berstandar national glycohemoglobin standardization program (NGSP). Aktivitas fisik ditentukan melalui kuisioner global physical activity questionnaire (GPAQ)-versi Bahasa Indonesia. Tekanan darah dan data antropometrik diukur secara langsung. Analisis bivariat dan multivariat dilakukan dengan IBM SPSS 23.Hasil. Dilakukan analisis terhadap 54 subjek. Mayoritas subjek adalah perempuan (79,6%) dan rerata umur adalah 38,8 tahun. Proporsi prediabetes mencapai 31,5%. Analisis multiavariat menunjukkan hubungan bermakna antara riwayat paternal DMT2 (adjusted OR 7,520; IK 95%=1,071-52,784), lingkar pinggang berisiko (adjusted OR 5,482; IK 95%=1,019-29,504) terhadap status prediabetes.Simpulan. Riwayat paternal DMT2 dan lingkar pinggang berkaitan dengan status prediabetes pada anak dari penderita DMT2.Kata Kunci: Anak penderita DM tipe 2, HbA1C, intoleransi glukosa, prediabetes The Role of Paternal History of Type 2 Diabetes Mellitus on Prediabetes Status among The Offspring of Type 2 Diabetes Mellitus Patients Introduction. Since patients with type 2 diabetes mellitus (T2DM) often present with one or more chronic complications, at the time of diagnosis, early detection and prevention is essential to reduce T2DM-associated mortality and morbidity, espescially among high risk population such as the offspring of T2DM. This study aimed to investigate several factors associated with prediabetes status among the offsprings of T2DM patients.Methods. A cross-sectional study was conducted involving 54 offsprings of T2DM patients. Subjects were recruited consecutively. We collected demographic data, anthropometric measurement, blood pressure, and HbA1c level. Physical activity were assessed by using Indonesian version of global physical activity questionnaire (GPAQ). Prediabetes status was investigated by standardized national glycohemoglobin standardization program (NGSP) HbA1c. Bivariate statistical and multivariate analysis was performed by using IBM SPSS 23.Results: The majority of subjects were female (79.6%) and the mean age was 38.8 years old. The proportion of prediabetes was 31.5%. Multivariate analysis showed significant association among paternal history of T2DM (adjusted OR 7.520; 95%CI=1.071-52.784), waist circumference at risk (adjusted OR 5.482; 95%CI=1.019-29.504), and prediabetes status.Conclusion: Paternal history of T2DM and waist circumference were associated with prediabetes status among the offspring of T2DM patients.

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The genetics of type 2 diabetes

Cited by 30 publications

References 61 publications

Comparative Evaluation of DPP-IV Inhibitors and other Oral Hypoglycaemic Agents used Either Alone or in Combination with Reference to Glycemic Targets in Patients with Type 2 Diabetes Mellitus

Comparative Evaluation of DPP-IV Inhibitors and other Oral Hypoglycaemic Agents used Either Alone or in Combination with Reference to Glycemic Targets in Patients with Type 2 Diabetes Mellitus

Size of myocardial infarction induced by ischaemia/reperfusion is unaltered in rats with metabolic syndrome

Peran Riwayat Ayah Diabetes Melitus Tipe 2 pada Status Prediabetes Anak Kandung Penderita Diabetes Melitus Tipe 2

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