The Genomics Revolution: Will Canine Atopic Dermatitis Be Predictable and Preventable?

Review: Role of genetics and the environment in the pathogenesis of canine atopic dermatitis

“…We also may be able to identify dogs that may have a poor response or an increased risk of adverse effects to certain anti‐inflammatory drugs. Finally, it may be possible to discover atopic genotypes in young dogs and manage environmental and other factors to minimize their risk of developing clinical AD …”

Canine atopic dermatitis: breed risk in Australia and evidence for a susceptible clade

“…Extended selection for specific morphological phenotypes in purebred dogs has resulted in a relatively limited gene pool, leading to reduced genetic diversity of a specific breed or breed groups, and provides a powerful approach with which to investigate the genetics of inherited diseases in dogs . A number of genetic and genomic studies on CAD have reported that identifying relevant genes may require large populations from one geographical location . This will be facilitated through knowledge of dog breeds with a confirmed increase in disease susceptibility.…”

The Most Common Allergic Diseases in Dogs

“…Diagnosis of this disease cannot be made immediately after questioning the dog's owner about its medical history (De Boer and Hillier 2001). This is due to the diversity of the clinical picture, which may depend on genetic factors, the extent of the lesions, the stage of the disease (acute or chronic) and the presence of secondary microbial infections or other symptoms (Wilhem et al 2001;Nutall 2013). It is one of the most common immune disorders and one of the most commonly clinically diagnosed diseases, affecting about 10-15% of the canine population (Griffin et al 2001).…”