The genus Carpesium: A review of its ethnopharmacology, phytochemistry and pharmacology

Three New Highly Oxygenated Germacranolides from Carpesium Divaricatum and Their Cytotoxic Activity

“…The genus Carpesium (Asteraceae) includes 25 species worldwide, most of which are distributed across Asia and Europe, particularly in southwest China [ 1 , 2 ]. In China, Korea, and Japan, many Carpesium species have been used for the treatment of fevers, colds, bruises, and snake bites, due to their antipyretic, analgesic, vermifugic, hemostatic, detoxifying, and anti-inflammatory properties [ 2 ]. The genus is rich in diverse sesquiterpenoid lactones, such as eudesmanolides and germacranolides [ 2 , 3 , 4 , 5 , 6 ].…”

“…In China, Korea, and Japan, many Carpesium species have been used for the treatment of fevers, colds, bruises, and snake bites, due to their antipyretic, analgesic, vermifugic, hemostatic, detoxifying, and anti-inflammatory properties [ 2 ]. The genus is rich in diverse sesquiterpenoid lactones, such as eudesmanolides and germacranolides [ 2 , 3 , 4 , 5 , 6 ]. Previous investigations indicate that sesquiterpenoid lactones possessing an α -methylene- γ -lactone moiety are cytotoxic to human cancer cells [ 2 , 3 , 4 , 5 , 6 , 7 ].…”

Vlasouliolides A-D, four rare C17/C15 sesquiterpene lactone dimers with potential anti-inflammatory activity from Vladimiria souliei

“…Naturally occurring sesquiterpene lactone dimers (SLDs) are a type of complex found in natural products with many pharmacological activities12. Since the first SLD absinthin was isolated from Artemisia absinthium in 19533, more than 160 SLDs have been obtained.…”

The effect of carabrone on mitochondrial respiratory chain complexes inGaeumannomyces graminis

“…Studies have shown that the reaction between the electrophilic a-methylene-c-lactone of sesquiterpene lactones and nucleophilic intracellular thiols constitutes the molecular mechanism of this cytotoxicity (Han et al 2009;Liu et al 2009). Carabrone is a bicyclic sesquiterpenic lactone isolated from Carpesium macrocephalum, which is widely distributed in Asia and Europe (Minato et al 1964;Feng et al 2010;Zhang et al 2015). The extraction of carabrone is described by Minato et al (1964).…”