The genus Sida L. (Malvaceae): An update of its ethnomedicinal use, pharmacology and phytochemistry

Rodrigues, Felicidade Caroline; Oliveira, Antônio Fernando Morais de

doi:10.1016/j.sajb.2020.04.030

Cited by 21 publications

(9 citation statements)

References 48 publications

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“…The genus Sida L. is one of the most diverse in the Malvaceae family, with about 200 species scattered in every part of tropical and subtropical regions in the world [ 18 , 34 , 35 ]. In addition, 142 chemical constituents belonging to various classes have been reported for Sida sp.…”

Section: Discussionmentioning

confidence: 99%

“…In several countries, Sida L . (Malvaceae) has been used for centuries in traditional medicines for the prevention and treatment of different diseases such as diarrhea, dysentery, gastrointestinal and urinary infections, cancer, malaria, and helminth infections [ 11 – 18 ]. Moreover, during the last decade, Jatsa et al [ 19 – 21 ] have demonstrated the in vitro and in vivo anti-schistosomal potency of Sida pilosa .…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Assessment of the Cercaricidal Activity of Sida acuta Burm. F. and Sida rhombifolia Linn. (Malvaceae) Hydroethanolic Extracts, Cytotoxicity, and Phytochemical Studies

Femoe

Fassi

Jatsa

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Despite the global efforts, schistosomiasis remains a public health problem in several tropical and subtropical countries. One of the major challenges in the fight against schistosomiasis is the interruption of the parasite life cycle. Here, we evaluated the anticercarial, cytotoxicity, and phytochemical profiles of Sida acuta (HESa) and Sida rhombifolia (HESr) hydroethanolic extracts (Malvaceae). Schistosoma mansoni cercaria was collected from fifteen Biomphalaria pfeifferi-infected snails. Twenty-five cercariae were incubated in duplicate with different concentrations (31.25–1,000 μg/mL) of HESa or HESr. The cercaria viability was monitored at 30 min time intervals for 150 min, and the concentration-response curve of each plant extract was used to determine their respective lethal concentration 50 (LC50). Additionally, the cytotoxicity profile of each plant extract was evaluated on the Hepa 1–6 cell line at a concentration range of 15.625–1,000 µg/mL using the WST-8 assay method and its inhibitory concentration 50 (IC50) was calculated. Moreover, phytochemical characterization of each plant extract was carried out by HPLC-MS. Both extracts exhibited cercaricidal activity in a time- and concentration-dependent manner. At 30 min time point, HESa (LC50 = 28.41 ± 3.5 µg/mL) was more effective than HESr (LC50 = 172.42 ± 26.16 µg/mL) in killing S. mansoni cercariae. Regarding the cytotoxicity effect of both extracts, the IC50 of HESa (IC50 = 109.67 µg/mL) was lower than that of HESr (IC50 = 888.79 µg/mL). The selectivity index was 3.86 and 5.15 for HESa and HESr, respectively. Fifteen compounds were identified from HESa and HESr after HPLC-MS analysis. N-Feruloyltyramine, a polyphenol, and thamnosmonin, a coumarin, were identified in both extracts. HESa and HESr displayed cercaricidal activity and were not toxic on Hepa 1–6 cell line. Based on the selectivity index of these extracts, S. rhombifolia extract could be more effective on S. mansoni cercariae than S. acuta extract. This study could provide baseline information for further investigations aiming to develop plant-based alternative drugs against S. mansoni.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro Assessment of the Cercaricidal Activity of Sida acuta Burm. F. and Sida rhombifolia Linn. (Malvaceae) Hydroethanolic Extracts, Cytotoxicity, and Phytochemical Studies

Femoe

Fassi

Jatsa

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…showed molluscicidal activity against the snail Biomphalaria glabrata (Say), the intermediated host of Schistosoma mansoni Sambon (Diplostomida: Schistosomatidae) [27]. Moreover, several of the identified plants, such as C. erecta, Lourteigia ballotaefolia (Kunth) R.M.King and H.Rob., A. absinthium, Centratherum punctatun Cass., Sida spp., and Solanum lycocarpum A.St.-Hil., contain compounds with medical properties or have been traditionally used as medicinal plants [28][29][30][31][32][33][34].…”

Section: Arthropods and Plants Diversitymentioning

confidence: 99%

The Temporal and Spatial Variation of Arthropod Associations Inhabiting Non-Crop Vegetation in a Sisal Crop, Agave sisalana in the Caatinga Biome

et al. 2021

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Sisal, Agave sisalana Perrine, is cultivated for fiber production, with Brazil being its leading producer. Nowadays, given the increasing interest in organic products, the market for sisal could become an economical alternative for rural areas with low economic inputs. However, sisal is threatened by different pests and diseases. Conservation biological control could contribute to the limitation of these plant enemies, but this agroecosystem is poorly known. In this context, we aimed: (i) to identify the diversity of plants and arthropods and their potential relations, (ii) to study the spatial patterns of arthropods and plants in function of the proximity to the margin of the field, and (iii) to determine the minimum sampling effort needed to record the occurring biodiversity in a sisal crop. Arthropods were sampled using pit-fall traps located close to the border and in the inner plant of the sisal crop from June to September. Simultaneously, plant species and their abundance in quadrats next to each pitfall were recorded. Diversity indexes were calculated to describe the biodiversity, a redundancy analysis was performed to analyze relations among arthropods and plants and the spatial distribution was evaluated using the non-parametric Wilcoxon rank-sum test. The redundancy analysis and the Wilcoxon test revealed a temporal and spatial distribution of arthropods and plants during the period of study. Results indicated (i) similar temporal diversity patterns from June to July for both plants and arthropods, with a maximum in July, whereas in September the biodiversity increased for arthropods and decreased for plants; (ii) the importance of particular plant species for Collembola; and (iii) that arthropods seem to colonize the sisal crop from the fields beyond the crop during the rainy season. These results provide new information about arthropods and plant biodiversity from an agroecosystem in a semi-arid region and raise further queries about the management of sisal crops.

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“…There are multiple benefits of SCs, including anti-inflammatory and analgesic activity, antibacterial, antioxidant, antidiabetic properties, anticancer activity, and wound healing properties. Certain herbal formulations derived from the genus of Sida have already been patented for various health concerns [7,8]. In the years between 1980 and 2021, the term "Sida cordifolia" was associated with a variety of terms to compile information published between these years.…”

Section: Introductionmentioning

confidence: 99%

Sida cordifolia - an Update on Its Traditional Use, Phytochemistry, and Pharmacological Importance

Srinivasan¹,

Murali²,

Sivakrishnan³

2022

Int J Pharm Res Allied Sci

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The genus Sida L. (Malvaceae): An update of its ethnomedicinal use, pharmacology and phytochemistry

Cited by 21 publications

References 48 publications

In Vitro Assessment of the Cercaricidal Activity of Sida acuta Burm. F. and Sida rhombifolia Linn. (Malvaceae) Hydroethanolic Extracts, Cytotoxicity, and Phytochemical Studies

In Vitro Assessment of the Cercaricidal Activity of Sida acuta Burm. F. and Sida rhombifolia Linn. (Malvaceae) Hydroethanolic Extracts, Cytotoxicity, and Phytochemical Studies

The Temporal and Spatial Variation of Arthropod Associations Inhabiting Non-Crop Vegetation in a Sisal Crop, Agave sisalana in the Caatinga Biome

Sida cordifolia - an Update on Its Traditional Use, Phytochemistry, and Pharmacological Importance

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