Water vapor plays a major role in the process of radiation, cloud formation, energy exchange within a system, and remains a key component of the Earth's atmosphere. The purpose of this study is to examine the water vapor content of the troposphere over Europe and the Northern Atlantic. Both temporal and spatial differences were examined for total column water vapor (TCWV) and vertically integrated water vapor flux (IWVF) based on ERA-Interim reanalysis data. The statistical relationship between circulation patterns, as expressed by empirical orthogonal function (EOF) modes, and TCWV were examined, as were statistical relationships between distinguished advection types and TCWV and IWVF. The study confirmed the significance of atmospheric circulation in the formation of moisture content in the winter season (i.e., January) and its markedly lower impact in other seasons. The relationships noted in the study are characterized by statistically significant spatial differentiation. Spatial pattern analysis was used to identify six regions with different moisture content over the course of the year. The boundaries of the regions confirm the significant role of local factors impacting moisture content.