The global burden of asthma: executive summary of the GINA Dissemination Committee Report

Masoli, Matthew; Fabian, Denise; Holt, Shaun; Beasley, Richard

doi:10.1111/j.1398-9995.2004.00526.x

Cited by 3,100 publications

(2,408 citation statements)

References 7 publications

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“…Asthma is the most common disorders of the airways of the lungs and is one of the major global health problems [199]. It is characterized by chronic inflammation of the airways involving variable and recurrent airflow obstruction and bronchial hyperreactivity associated with airway remodelling [200,201].…”

Section: Asthmamentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals,

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Section: Asthmamentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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“…23 As such, the joint association between the TLR2 and T1D and allergic asthma may represent a common susceptibility pathway before CD4 differentiation, or a pathway involving the regulatory T cells. This is of interest in light of the fact that for both diseases, the prevalence is increasing, 34,35 warranting studies exploring possible common factors influencing disease susceptibility.…”

Section: T1d Versus Allergic Asthmamentioning

confidence: 99%

A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma

et al. 2009

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Type 1 diabetes (T1D) and allergic asthma are immune-mediated diseases. Pattern recognition receptors are proteins expressed by cells in the immune system to identify microbial pathogens and endogenous ligands. Toll-like receptors (TLRs) and CD14 are members of this family and could represent a molecular link between microbial infections and immune-mediated diseases. Diverging hypotheses regarding whether there exists a common or inverse genetic etiology behind these immunemediated diseases have been presented. We aimed to test whether there exist common or inverse associations between polymorphisms in the pattern recognition receptors TLR2, TLR4 and CD14 and T1D and allergic asthma. Eighteen single nucleotide polymorphisms (SNPs) were genotyped in TLR2 (2), TLR4 (12) and CD14 (4) in 700 T1D children, 357 nuclear families with T1D children and 796 children from the 'Environment and Childhood Asthma' study. Allele and haplotype frequencies were analyzed in relation to diseases and in addition transmission disequilibrium test analyses were performed in the family material. Both T1D and allergic asthma were significantly associated with the TLR2 rs3804100 T allele and further associated with the haplotype including this SNP, possibly representing a susceptibility locus common for the two diseases. Neither TLR4 nor CD14 were associated with T1D or allergic asthma.

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“…In the developed world, between 5% and 10% of the adult population suffer from asthma 3. Depending on the criteria used for diagnosis, OSAS affects 2‐4% of men and 1‐2% of women in the United States 4, with an estimated prevalence of 3‐6% in the general Spanish population 5.…”

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confidence: 99%

Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea

Serrano-Pariente

Plaza

Soriano

et al. 2016

Allergy

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BackgroundContinuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies.MethodsProspective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index ≥20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention‐to‐treat basis.ResultsThe mean ± SD score of the ACQ decreased from 1.39 ± 0.91 at baseline to 1.0 ± 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 ± 1.38 to 5.63 ± 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients’ weight.ConclusionsAsthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.

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The global burden of asthma: executive summary of the GINA Dissemination Committee Report

Cited by 3,100 publications

References 7 publications

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma

Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea

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