In current research on the Anthropocene, assessing the impact of human activities via stratigraphic records of sediments and demarcating the Anthropocene epoch globally are critical scientific issues that urgently need to be addressed. The northeastern Qinghai-Xizang Plateau (QXP), where humans first settled permanently in large numbers in the QXP, has varying sedimentary environments that are extremely sensitive to human activities. In contrast to other regions of the QXP, the northeastern sector boasts a richer array of climatic and environmental reconstruction sequences. This distinctive feature renders it an exemplary locale for investigating the stratigraphic boundary of the Anthropocene. Through in-depth analysis and integration of existing paleoclimate and paleoenvironment sequences in the northeastern QXP, we draw the following conclusions: (1) Throughout the past millennium, the impact of human activities on the environment of the northeastern QXP has become increasingly significant, especially in the past 200–300 years, gradually overshadowing climatic factors. (2) Since AD 1950, multiple physicochemical indicators related to human activities in the northeastern QXP have shown exponential growth, forming a distinct peak within the past millennium and clearly depicting the global “Great Acceleration” phenomenon and its development process. (3) Intensified human activities have driven swift environmental shifts and “decoupled” the interplay between climatic variations and the ecological environment, propelling the northeastern QXP into the “Early Anthropocene” from the “Late Holocene”. On the basis of the above findings, we construct a model suitable for identifying the stratigraphic boundary of the Anthropocene in the northeastern QXP and note that since the ecological environment in the northeastern QXP has entered the “Early Anthropocene”, the climate signals of certain physicochemical indicators in sediments are gradually becoming weaker, whereas the signals of human activities are becoming stronger.