The Global Prevalence of Class 1 Integron and Associated Antibiotic Resistance in <i>Escherichia coli</i> from Patients with Urinary Tract Infections, a Systematic Review and Meta-Analysis

Halaji, Mehrdad; Feizi, Awat; Mirzaei, Arezoo; Ebrahim‐Saraie, Hadi Sedigh; Fayyazi, Amirhossein; Ashraf, Ali; Havaei, Seyed Asghar

doi:10.1089/mdr.2019.0467

Cited by 31 publications

(22 citation statements)

References 52 publications

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“…UTI is the most common disease among KTPs [16,17], and the main cause of UTI is UPEC [18]. Furthermore, quinolones are the most common antibiotic used to treat UTI.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Plasmid‐Mediated Quinolone Resistance and Serogroup Distributions of Uropathogenic Escherichia coli among Iranian Kidney Transplant Patients

Sadeghi

Halaji

Fayyazi

et al. 2020

BioMed Research International

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Introduction. Urinary tract infection (UTI) is one of the most frequent infections in kidney transplant patients (KTPs). This infection is mainly caused by uropathogenic Escherichia coli (UPEC). Plasmid-mediated quinolone resistance (PMQR) was also increasingly identified in UPEC. This study proposed to investigate the frequency of quinolone-resistance plasmid genes and the O-antigen serogroup among UPEC isolated from KTPs and non-KTP with UTI. Methods. Totally, 114 UPEC isolates from 49 KTPs and 65 non-KTPs patients diagnosed with an UPEC-associated UTI were obtained from June 2019 to December 2019 at three laboratory centers in Isfahan, Iran. The isolates were confirmed through phenotypic and genotypic methods. Moreover, the antimicrobial susceptibility test to nalidixic acid, ciprofloxacin, norfloxacin, and ofloxacin was performed using a disk diffusion method. The presence of the qnr gene as well as the serogroup distribution was identified using the PCR method. Result. According to data, the distribution of O1, O2, O4, O16, and O25 serogroups were 3.5%, 2.6, 3.5, 3.5, and 20.2%, respectively. Antibiotic susceptibility pattern revealed that the highest and lowest resistance rates were to nalidixic acid (69.3%) and norfloxacin (43.9%), respectively. Also, the frequency of qnrS and qnrB genes were 33.3% and 15.8%, respectively, while none of the isolates was found to be positive for the qnrA gene. There was no significant association between the presence of qnr genes and higher antibiotic resistance. Conclusion. This study recognized that the qnrS gene, O25 serotype, and resistance to nalidixic acid had the highest frequencies in UPEC strains isolated from UTI patients.

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“…UTI is the most common disease among KTPs [16,17], and the main cause of UTI is UPEC [18]. Furthermore, quinolones are the most common antibiotic used to treat UTI.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Plasmid‐Mediated Quinolone Resistance and Serogroup Distributions of Uropathogenic Escherichia coli among Iranian Kidney Transplant Patients

Sadeghi

Halaji

Fayyazi

et al. 2020

BioMed Research International

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“…Class 1 integrons are by far the most prevalent and clinically relevant. Recently, the class 1 integrons were found in a considerable fraction of E. coli isolates [29].…”

Section: Mobile Genetic Elementsmentioning

confidence: 99%

The Escherichia coli SOS Response: Much More than DNA Damage Repair

Podlesek¹,

Bertok²

2023

Escherichia Coli - Old and New Insights

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The Escherichia coli SOS response is an inducible DNA damage repair pathway controlled by two key regulators, LexA, a repressor and RecA, an inducer. Upon DNA damage RecA is activated and stimulates self cleavage of LexA, leading to, in E. coli, derepresion of approximately 50 SOS genes. The response is triggered by exogenous and endogenous signals that bacteria encounter at a number of sites within the host. Nevertheless, besides regulating DNA damage repair the SOS response plays a much broader role. Thus, SOS error prone polymerases promote elevated mutation rates significant for genetic adaptation and diversity, including antibiotic resistance. Here we review the E. coli SOS response in relation to recalcitrance to antimicrobials, including persister and biofilm formation, horizontal gene tranfer, gene mobility, bacterial pathogenicity, as well SOS induced bacteriocins that drive diversification. Phenotypic heterogeneity in expression of the SOS regulator genes, recA and lexA as well as colicin activity genes is also discussed.

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“…In another definition MDR means non-susceptibility to at minim one agent in three or more antimicrobial categories, XDR means non-susceptibility to at minim one agent in all but two or fewer antimicrobial categories [18]. In bacteria, integrons as transposable elements and extended spectrum β-lactamases (ESBLs) enzymes in a variety of Gram negative bacteria are related to an increased resistance to commonly used antibiotics [19][20][21]. There is no denying the fact that if there is no efficient timely respond, the problem of resistance to antibiotic is becoming a huge difficulty in the future years.…”

Section: Introductionmentioning

confidence: 99%

A retrospective cross-sectional survey on nosocomial bacterial infections and their antimicrobial susceptibility patterns in hospitalized patients in northwest of Iran

et al. 2021

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Objective Nosocomial infections (NIs) are known as one of the remarkable problems in all countries. This study is aimed to estimate the prevalence rate of nosocomial bacterial agents with antimicrobial susceptibility pattern in hospitalized patients. This study was conducted from April 2017 to September 2018, on 4029 hospitalized patients. We set out to recognize the commonest bacterial infections and antimicrobial susceptibility patterns of nosocomial infection. Results Of the 4029 patients, 509 (12.6%) of them were culture positive. Of these Escherichia coli (E. coli) (98.3%) and Staphylococcus epidermidis (S. epidermidis) (37.5%) were the most abundant bacterial identified in the urinary tract and bloodstream cultures respectively, Moreover, Acinetobacter spp. (100%) and Pseudomonas aeruginosa (22.2%) were the most abundant organisms detected in the respiratory system. According to susceptibility testing results, 370 (80.5%) and 264 (57.3%) in Gram-negatives and 44 (91.7%) and 35 (72.9%) in gram positives isolated strains were classified as multidrug-resistant (MDR) and extensive drug-resistant (XDR) strain respectively. On account of the high prevalence of MDR and XDR bacterial species, there is a pressing need for the expansion of new strategies on antibiotic supervision and infection control to introduce new guideline on empirical antibiotic therapy.

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The Global Prevalence of Class 1 Integron and Associated Antibiotic Resistance in Escherichia coli from Patients with Urinary Tract Infections, a Systematic Review and Meta-Analysis

Cited by 31 publications

References 52 publications

Characterization of Plasmid‐Mediated Quinolone Resistance and Serogroup Distributions of Uropathogenic Escherichia coli among Iranian Kidney Transplant Patients

Characterization of Plasmid‐Mediated Quinolone Resistance and Serogroup Distributions of Uropathogenic Escherichia coli among Iranian Kidney Transplant Patients

The Escherichia coli SOS Response: Much More than DNA Damage Repair

A retrospective cross-sectional survey on nosocomial bacterial infections and their antimicrobial susceptibility patterns in hospitalized patients in northwest of Iran

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