The global, regional, and national burden of atopic dermatitis in 195 countries and territories: An ecological study from the Global Burden of Disease Study 2017

Abstract

Introduction: Numerous population-based studies have focused on the global prevalence of atopic dermatitis (AD), but there are few studies on the global trends of the burden associated with AD. Methods: We analyzed the global AD trends in 2017 in 195 countries worldwide using the Global Burden of Disease (GBD) Study database, including prevalence rates, age and sex patterns, and AD burden, using disability-adjusted life years (DALYs). Age-standardized DALYs were also compared to the sociodemographic index values of all the countries in 2017. Results: The age-specific DALYs in 2017 showed a right-skewed distribution, with the highest DALYs between 1 and 5 years of age. Females had a higher burden of AD throughout all age groups and geographic regions. The GBD super region with the greatest burden of DALYs caused by AD was high income (178.63 DALYs per 100,000 males, 231.8 for females), and the country with the highest DALYs was Sweden (326.91). The GBD super region with the lowest age-standardized DALY burden caused by AD was south Asia (84.51 DALYs per 100,000 males, 100.54 for females). Conclusion: There is a large GBD caused by AD. The observed burden is the greatest in resource-rich countries, females, and young children. (JAAD Int 2021;2:12-8.)

Advances in atopic dermatitis

“…This is reflected in the Global Burden of Disease study, showing that dermatitis was the leading skin disease, measured by disability-adjusted life-years. 4,8,9 Patients with AD are more likely to require treatment for associated atopic comorbidities (such as asthma, allergic rhinitis and type-1 hypersensitivity to food), therefore, suffering an even greater disease burden. 9 Increased prevalence of depression and anxiety is also seen.…”

“…Adult onset AD (late onset) is also recognised. 2,4 While many cases of AD are mild, and can be managed with simple topical treatment, up to 50% of AD cases Regular application of topical emollients alongside treatment with topical corticosteroids or calcineurin inhibitors forms the foundation of treatment of all AD.…”

Urea-Based Patches with Controlled Release for Potential Atopic Dermatitis Treatment

“…Skin barrier disfunction, affecting people regardless of age, leads to transepidermal water loss and allergens penetration, which accelerate the course of a disease such as atopic dermatitis (AD) [ 1 ]. The symptoms are dry, itchy skin with a bacterial infection, which is difficult to treat and usually requires using different products for each symptom [ 2 ].…”

study on the efficacy of Staphyloccus aureus biofilm formation in atopic dermatitis severity

“…Patients who suffer from atopic dermatitis (AD; often referred to as "atopiceczema") have a higher likelihood of experiencing recurrent skin infections. (1)(2)(3)(4)(5)(6) Even while betahaemolytic streptococci may potentially be implicated, the most prevalent infecting organism is staphylococcus aureus. (7) In more severe situations, a cutaneous bacterial infection may develop abscesses, fever, and lymphadenopathy.…”