The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019

Chong, Bryan; Kong, Gwyneth; Kannan, Shankar; Chew, H.S. Jocelyn; Lin, Chaoxing; Goh, Rachel; Chin, Yip Han; Tan, Darren Jun Hao; Chan, Kai En; Lim, Wen Hui; Syn, Nicholas; Chan, Siew Pang; Wang, Jiong‐Wei; Khoo, Chin Meng; Dimitriadis, Georgios K.; Wijarnpreecha, Karn; Sanyal, Arun J.; Noureddin, Mazen; Siddiqui, Mohammad Shadab; Foo, Roger; Mehta, Anurag; Figtree, Gemma A.; Hausenloy, Derek J; Chan, Mark Y; Ng, Cheng Han; Muthiah, Mark; Mamas, Mamas A.; Chew, Nicholas

doi:10.1016/j.metabol.2023.155402

Cited by 77 publications

(34 citation statements)

References 44 publications

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“…31 Additionally, data from Zhang et al indicated that the global childhood diabetes incidence rate in high SDI regions was 26.24 per 100,000 in 2019, surpassing the rates of 10.06 in low SDI regions, 10.6 in low-middle SDI regions, 9.17 in middle SDI regions, and 12.56 in high-middle SDI regions. 32,33 These findings further imply that the occurrence of cardiovascular diseases in regions with a high SDI might be influenced by underlying factors. In contrast, the relatively lower prevalence of thalassemia in the low SDI region may suggest that, in the low-resource setting, the limitation of insufficient medical resources and access to healthcare makes it hard to achieve full coverage and detection of diseased human populations.…”

Section: Discussionmentioning

confidence: 90%

Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades

Tang,

Zhang,

Deng

et al. 2023

Eur J Clin Investigation

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BackgroundTo assess the prevalence trend and contributing factors of heart failure (HF) impairment with thalassemias at global, regional and national levels.MethodsData on HF impairment with thalassemias was collected from the Global Burden of Disease study. The absolute number and prevalence of the disease were systematically collected for each year, and the estimated annual percentage changes (EAPC) in HF impairment were calculated by gender, region and country to measure temporal trends.ResultsThalassemias have caused a significant global burden since 1990, and the case number of HF related to thalassemias has been steadily increasing. The highest case number of HF impairments with thalassemias is observed in China (7739 cases) and the highest prevalence is in Pakistan (1.61 per 100,000) currently. Besides, the middle sociodemographic index (SDI) region carries the highest burden of comorbid disease yet exhibits the most evident trend for improvement across the five regions (EAPC = −.98). The burden of thalassemias and comorbid HF is generally higher in males than females with the gender gap growing chasm in the future. Besides, the hotspots of HF impairment with thalassemias have gradually shifted to low SDI regions, though middle SDI regions still hold a relatively higher prevalence (.37 per 100,000) across different regions.ConclusionsThe burden of thalassemias and accompanying HF, as well as their temporal trends, vary greatly across countries and regions. These findings can improve understanding of these conditions and guide policymakers in developing appropriate policies to address disparities between countries.

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Section: Discussionmentioning

confidence: 90%

Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades

Tang,

Zhang,

Deng

et al. 2023

Eur J Clin Investigation

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“…Because increasing obesity-related mortality trends underlie the concerning growing global burden of metabolic diseases, intervention for this specific high-risk population may also be important. 43…”

Section: Discussionmentioning

confidence: 99%

National Trends in Mortality and Urgent Dialysis after Acute Hypertension in Japan From 2010 Through 2019

Matsuki,

Genma,

Mandai

et al. 2023

Hypertension

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Background: Despite increasing incidences of hypertension, recent trends in mortality and urgent dialysis following acute hypertension (AHT) remain undetermined. Methods: This retrospective observational cohort study evaluated 50 316 hospitalized AHT patients from 2010 to 2019, using an administrative claims database in Japan. We examined trends in incidence, urgent dialysis, mortality, and its risk factors using Poisson regression models. Using ICD-10 codes, AHT was categorized into 5 spectrums: malignant hypertension ( n =1792), hypertensive emergency ( n =17 907), hypertensive urgency ( n =1562), hypertensive encephalopathy ( n =6593), and hypertensive heart failure (HHF; n =22 462). Results: The median age of the patients was 76 years, and 54.9% were females. The total AHT incidence was 70 cases per 100 000 admission year. The absolute death rate increased from 1.83% (95% CI, 1.40–2.40) to 2.88% ([95% CI, 2.42–3.41]; Cochran-Armitage trend test, P< 0.0001). Upward trends were observed in patients aged ≥80, with lean body mass index ≤18.4, and with HHF. Urgent dialysis rates increased from 1.52% (95% CI, 1.12–2.06) to 2.60% (2.17–3.1; Cochran-Armitage trend test; P= 0.0071) in 48 235 patients, excluding maintenance dialysis patients. Older age, male, lean body mass, malignant hypertension, HHF, and underlying chronic kidney disease correlated with higher mortality risk; greater hospital volume correlated with lower mortality risk; and malignant hypertension, HHF, diabetes, chronic kidney disease, and scleroderma correlated with a higher risk of urgent dialysis. Conclusions: Mortality and urgent dialysis rates following AHT have increased. Aging, complex comorbidities, and HHF-type AHT contributed to the rising trend of mortality.

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“…Our findings are concordant with current literature, showing heterogeneity in the knowledge across various cardiometabolic diseases and subgroups of the population ( 38 ). In recent years, cardiometabolic diseases have been on the rise across the globe ( 39 ), especially in Asia, attributed to globalization, socioeconomic changes, technological advancements, and sedentary living ( 5 , 40 – 42 ). The study extends the current literature by providing a comprehensive overview of the associations between knowledge, attitudes, perceived risk, and actions taken toward cardiometabolic health in a multi-ethnic Singaporean population.…”

Section: Discussionmentioning

confidence: 99%

General Public’s knowledge, awareness, and perception of Cardiometabolic diseases: data from a Singapore study population

et al. 2023

Self Cite

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BackgroundHealth literacy and illness perception play crucial roles in tackling the cardiometabolic disease epidemic. We aim to compare the attitudes, knowledge, self-perceived risks and actions taken, between individuals with and without metabolic risk factors (MFs).MethodsFrom 5 June to 5 October 2022, participants of the general public were invited to complete a self-administered questionnaire. MF status was defined as the presence of hypertension, hyperlipidemia, diabetes mellitus and/or current/previous smoking. Participants were assessed based on four categories (knowledge-based, attitude-based, perceived risk, and action-based) of questions pertaining to four cardiometabolic diseases – diabetes mellitus, hypertension, hyperlipidemia, and non-alcoholic fatty liver disease.ResultsA total of 345 participants were enrolled, of whom 34.5% had at least one MF. Compared to those without MFs, participants with MFs had lower knowledge scores, but higher perceived risk scores across all cardiometabolic diseases. The largest knowledge gap pertained to hypertension-related questions. After adjustment, linear regression demonstrated that the presence of MFs (β:2.752, 95%CI: 0.772–4.733, p = 0.007) and higher knowledge scores (β:0.418, 95%CI: 0.236–0.600, p < 0.001) were associated with higher perceived risk. Despite increased perceived risk in those with MFs, this translated to only few increased self-reported preventive actions, when compared to those without MFs, namely the reduction in red meat/processed food consumption (p = 0.045) and increase in fruits/vegetables consumption (p = 0.009).ConclusionThis study identified a vulnerable subpopulation living with MFs, with high perceived risks, and discordant levels of knowledge and preventive actions taken. Nationwide efforts should be channeled into addressing the knowledge-to-action gap.

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The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019

Cited by 77 publications

References 44 publications

Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades

Changing trends in the prevalence of heart failure impairment with Thalassemias over three decades

National Trends in Mortality and Urgent Dialysis after Acute Hypertension in Japan From 2010 Through 2019

General Public’s knowledge, awareness, and perception of Cardiometabolic diseases: data from a Singapore study population

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