The globalization of nonalcoholic fatty liver disease: Prevalence and impact on world health

Rinella, Mary E.; Charlton, Francesca

doi:10.1002/hep.28524

Cited by 224 publications

(214 citation statements)

References 8 publications

Supporting

Mentioning

205

Contrasting

Unclassified

Order By: Relevance

“…Although the prevalence of NAFLD varies among studies due to the different sensitivities of the instruments used and the ethnic makeup of the populations studied, there is no doubt that the incidence of NAFLD is increasing to epidemic proportions, especially in developing countries. As the incidence of viral infections such as Hepatitis B virus (HBV) and Hepatitis C virus (HCV) is decreasing, NAFLD is becoming the most prevalent liver disease (Wang et al, 2014; Younossi et al, 2015; Rinella and Charlton, 2016). NAFLD encompasses a spectrum of diseases ranging from simple hepatic steatosis, to non-alcoholic steatohepatitis (NASH), to cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease

2016

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies (GWAS), genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13) may promote the development of NAFLD.

show abstract

Section: Introductionmentioning

confidence: 99%

Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease

2016

View full text Add to dashboard Cite

show abstract

“…Helicobacter pylori is the main pathologic cause of PU [3] and is one of the most important causes of gastric cancer [4]. Around 65-95 % of gastric and 50-75 % of duodenal ulcers are causally related to H. pylori infection [5]. Upper abdominal pain, abdominal fullness, gastroesophageal reflux and nausea are the most common symptoms of PU, and are jointly known as dyspepsia.…”

mentioning

confidence: 99%

Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial

et al. 2016

View full text Add to dashboard Cite

show abstract

“…It afflicts more than one third of the population in modern society, paralleling the escalation in global obesity prevalence [2]. A number of pathogenic factors may induce this disease, however, the molecular mechanisms of this disease still remain unknown [3].…”

Section: Introductionmentioning

confidence: 99%

ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data

Yang

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease with unclear molecular mechanisms. Our study intended to identify potential long non-coding RNAs (lncRNAs) and genes, and to determine the potential molecular mechanisms of NAFLD pathogenesis. Methods: The microarrays of GSE24031 and GSE57425 were downloaded from the Gene Expression Omnibus database. GSE24031 included 4 control and 4 model mice and GSE57425 included 3 control and 3 model mice on the basis of GPL1261 platform. Differentially expressed lncRNAs and mRNAs between control and NAFLD liver tissue were calculated. Gene ontology (GO), pathway enrichment analyses, co-expression network and PPI were performed to analyze the biological roles and pathways for the differentially expressed lncRNAs and mRNAs. Non-alcoholic steatohepatitis (NASH) rats were further chosen to investigate the key protein identified based on co-expression network and protein-protein interaction (PPI) network data. Results: A total of 6 significantly up-regulated and 39 down-regulated lncRNAs, 340 up-regulated and 281 down-regulated mRNAs were identified. LncRNA-mRNA co-expression network were analyzed to show a total of 16 key lncRNAs (node degree > 10) in NAFLD samples compared to control tissues. Three key protein identified on co-expression network and protein-protein interaction (PPI) network data were verified in NASH in vivo. The protein level of ATP-citrate lyase (Acly) was significantly increased while lncNONMMUT010685 and NONMMUT050689 in NAFLD samples, whose regulator gene was x-box binding protein 1 (XBP1) and receptor-interacting protein 1 kinase (RIPK1) respectively, were gradually reduced in NASH. Conclusion: In summary, we found a set of lncRNAs and mRNAs differentially expressed in the development of NAFLD. LncRNA Ttc39aos1 and Acly, may be crucial biomarkers for NAFLD. LncRNA NONMMUT010685 and NONMMUT050689, the regulator of XBP1 gene and RIPK1 gene respectively, played important roles in the development of NAFLD.

show abstract

The globalization of nonalcoholic fatty liver disease: Prevalence and impact on world health

Cited by 224 publications

References 8 publications

Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease

Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease

Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial

ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data

Contact Info

Product

Resources

About