The gold standard for interpretation of slow wave frequency in <i>in vitro</i> and <i>in vivo</i> recordings by extracellular electrodes

Sarna, Sushil K.

doi:10.1113/jphysiol.2013.260976

Cited by 10 publications

(6 citation statements)

References 8 publications

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“…When in direct contact with the serosa, the Reveal LINQ device was capable of recording slow waves with consistent quality compared to the control recordings from high-resolution FPC electrode arrays (Figure 3D), which have been validated as the gold-standard approach for extracellular gastric slow-wave recordings. 1,32 Altogether, the results of this study demonstrate that the commercially available Reveal LINQ cardiac monitoring device has the potential to function as an IGM. Such an application may provide an efficient solution for future slow-wave research where implanted electrode monitoring is required.…”

Section: Discussionmentioning

confidence: 58%

Translation of an existing implantable cardiac monitoring device for measurement of gastric electrical slow‐wave activity

Dowrick,

Jungbauer Nikolas,

Offutt

et al. 2023

Neurogastroenterology Motil

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BackgroundDespite evidence that slow‐wave dysrhythmia in the stomach is associated with clinical conditions such as gastroparesis and functional dyspepsia, there is still no widely available device for long‐term monitoring of gastric electrical signals. Actionable biomarkers of gastrointestinal health are critically needed, and an implantable slow‐wave monitoring device could aid in the establishment of causal relationships between symptoms and gastric electrophysiology. Recent developments in the area of wireless implantable gastric monitors demonstrate potential, but additional work and validation are required before this potential can be realized.MethodsWe hypothesized that translating an existing implantable cardiac monitoring device, the Reveal LINQ™ (Medtronic), would present a more immediate solution. Following ethical approval and laparotomy in anesthetized pigs (n = 7), a Reveal LINQ was placed on the serosal surface of the stomach, immediately adjacent to a validated flexible‐printed‐circuit (FPC) electrical mapping array. Data were recorded for periods of 7.5 min, and the resultant signal characteristics from the FPC array and Reveal LINQ were compared.Key ResultsThe Reveal LINQ device recorded slow waves in 6/7 subjects with a comparable period (p = 0.69), signal‐to‐noise ratio (p = 0.58), and downstroke width (p = 0.98) to the FPC, but with reduced amplitude (p = 0.024). Qualitatively, the Reveal LINQ slow‐wave signal lacked the prolonged repolarization phase present in the FPC signals.Conclusions & InferencesThese findings suggest that existing cardiac monitors may offer an efficient solution for the long‐term monitoring of slow waves. Translation toward implantation now awaits.

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Section: Discussionmentioning

confidence: 58%

Translation of an existing implantable cardiac monitoring device for measurement of gastric electrical slow‐wave activity

Dowrick,

Jungbauer Nikolas,

Offutt

et al. 2023

Neurogastroenterology Motil

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“…For example, in the cat stomach the frequency increased from 4.1 to 12.0 cpm (Xue et al, 1995) and in excised human tissue samples, frequency was reported to be as high as 7.4 cpm in the antrum, while the excised fundus (normally devoid of cyclic activity) had a frequency of 5.1 cpm (Rhee et al, 2011). Therefore, in vivo slow wave recordings are likely to be a more accurate representation of intrinsic physiology (Angeli et al, 2013;Sarna, 2013;Huizinga, 2017).…”

Section: Electrical Conduction System Of the Stomachmentioning

confidence: 99%

Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

et al. 2021

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Gastric pacing and stimulation strategies were first proposed in the 1960s to treat motility disorders. However, there has been relatively limited clinical translation of these techniques. Experimental investigations have been critical in advancing our understanding of the control mechanisms that innervate gut function. In this review, we will discuss the use of pacing to modulate the rhythmic slow wave conduction patterns generated by interstitial cells of Cajal in the gastric musculature. In addition, the use of gastric high-frequency stimulation methods that target nerves in the stomach to either inhibit or enhance stomach function will be discussed. Pacing and stimulation protocols to modulate gastric activity, effective parameters and limitations in the existing studies are summarized. Mathematical models are useful to understand complex and dynamic systems. A review of existing mathematical models and techniques that aim to help refine pacing and stimulation protocols are provided. Finally, some future directions and challenges that should be investigated are discussed.

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“…Even recently, the validity of extracellular recordings have been questioned and subsequently the frequency of slow wave events challenged (Bayguinov et al 2011, Rhee et al 2011). However, the claims have yet to be substantiated by other researchers, and the discrepancies of these results compared with historical and current knowledge appear to be attributed to limitations from the experimental setup, analysis techniques and differences between in vivo and in vitro setups , Sarna 2013. O'Grady et al (2013) provides an excellent review of the practical considerations for reliable in vivo based extracellular recordings.…”

Section: Experimental Challengesmentioning

confidence: 99%

Slow wave conduction patterns in the stomach: from Waller's Foundations to Current Challenges

Cheng

2014

Acta Physiol

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This review provides an overview of our understanding of motility and slow wave propagation in the stomach. It begins by reviewing seminal studies conducted by Walter Cannon and Augustus Waller on in vivo motility and slow wave patterns. Then our current understanding of slow wave patterns in common laboratory animals and humans is presented. The implications of slow wave dysrhythmic patterns that have been recorded in animals and patients suffering from gastroparesis are discussed. Finally, current challenges in experimental methods and techniques, slow wave modulation and the use of mathematical models are discussed.

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The gold standard for interpretation of slow wave frequency in in vitro and in vivo recordings by extracellular electrodes

Cited by 10 publications

References 8 publications

Translation of an existing implantable cardiac monitoring device for measurement of gastric electrical slow‐wave activity

Translation of an existing implantable cardiac monitoring device for measurement of gastric electrical slow‐wave activity

Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches

Slow wave conduction patterns in the stomach: from Waller's Foundations to Current Challenges

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