The Grape Fruit Bioflavonoid Naringin Protects Against the Doxorubicin-Induced Micronuclei Formation in Mouse Bone Marrow

Ch, Ganesh; Jagetia, ra; Reddy, Tiyagura Koti

doi:10.15406/ijmboa.2016.01.00006

Cited by 6 publications

(11 citation statements)

References 44 publications

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“…36,37 It also protects against radiation and doxorubicin induced chromosomal damage in mouse bone marrow cells. 35,38,39 It has been found to be anti-inflammatory, antidiabetic, antifibortic, antiosteoporotic, antidyslipidemic and protected against lipodystrophy and iron induced toxicity. [40][41][42][43][44] Naringin may also have protective effects on cognition and oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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Doxorubicin a photosensitive antibiotic is frequently used to treat various malignancies in clinics; however, doxorubicin is also taken up by the normal cells of the body leading to increased oxidative stress and subsequently DNA damage and dysfunction in the cells. The agents which can reduce the adverse effect of doxorubicin will of great value. The present study has attempted to study the effect of naringin a citrus flavonoid on the doxorubicininduced oxidative stress in mice liver. The mice were administered with 0, 1, 5 or 10mg/ kg body weight of doxorubicin and treated with 10mg/kg body weight of naringin before or after doxorubicin treatment. The glutathione concentration and lipid peroxidation and activities of glutathione-s-transferase, catalase and super oxide dismutase were studied at 0.5, 1, 2 and 4h post-treatment in the mouse liver. The doxorubicin increased the lipid peroxidation in a dose dependent manner at all the post treatment times. Conversely, it attenuated the activities of glutathione-s-transferase, catalase and super oxide dismutase in dose dependent fashion and time dependent manner. A similar effect was observed for glutathione concentration. Treatment of mice with naringin before or after doxorubicin treatment elevated all the antioxidants and reduced the doxorubicin -induced lipid peroxidation. The effect of naringin pretreatment was more effective when compared to its post treatment. The naringin was very effective in reducing the oxidative stress induced by doxorubicin as indicated by the elevated levels of glutathione concentration, glutathiones-transferase, catalase and super oxide dismutase. The pretreatment of naringin was better than its post treatment.

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Section: Introductionmentioning

confidence: 99%

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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“…The 10 mg/kg naringin was selected based on our earlier study where 10 mg/kg b. wt. of naringin was found to provide maximum protection against the DOX-induced DNA damage, when compared to other doses [30].…”

Section: Methodsmentioning

confidence: 86%

“…It has been reported to act as a cardioprotective, radioprotective, neuroprotective and antimutagenic agent [20][21][22][23][24][25][26][27]. Naringin has been found to reduce belomycin and doxorubicin induced genotoxicity in mice bone marrow, inhibit chemical carcinogenesis in mice, protect against iron-induced oxidative stress, lung fibrosis, osteoporosis, lipodystrophy and dyslipidemia in rats [28][29][30][31][32][33][34]. The administration of 16 g/kg b. wt.…”

Section: Doxorubicinmentioning

confidence: 99%

Naringin, a Grape Fruit Bioflavonoid Protects Mice Bone Marrow Cells against the Doxorubicin-Induced Oxidative Stress

Jagetia¹,

Lalrinengi²

2017

SOJB

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SOJ Biochemistry Open Access Research article cancer chemotherapeutic drugs, which acts on the specific phase of the cell cycle, especially the S phase of cell division [2]. The doxorubicin has been introduced in the clinics to treat various malignant diseases in the early 1970s and remains an integral part of various modern chemotherapeutic regimens where it is used to treat different malignant neoplasia including Hodgkin's and non-Hodgkin's lymphomas, myeloblastic leukemias, breast cancer, small cell lung cancer, ovarian cancer, childhood solid tumors, hepatocarcinomas, soft tissue sarcomas, Kaposi's sarcoma, and bone tumors [3-7].

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“…The elevated serum levels of CK-MB have been considered as a reliable marker of doxorubicin-induced cardiotoxicity [43]. The doxorubicin has been reported to increase the activity of CK-MB in mice, rats, and rabbits earlier [44][45][46][47][48][49][50][51][52][53]. The administration of rats with oltipraz reduced serum levels of CK-MB indicating that it protected the heart against the toxic effect of doxorubicin.…”

Section: Discussionmentioning

confidence: 99%

“…Oltipraz has been reported to protect rats against isoproterenol-induced heart failure [54]. Earlier a polyherbal preparation, antarth, Agele marmelos (bael), naringin, hesperidin, ellagic acid, carvedilol metformin, berberine, vanillic acid and chia seed oil have been reported to protect mice, rats and rabbits against the doxorubicininduced cardiotoxicity by reducing CK-MB activity and increasing antioxidants [44][45][46][47][48][49][50][51][52][53]. The iron chelator dexrazoxane (ICRF-187) has been used to reduce doxorubicin-induced cardiotoxicity in mice, rats, rabbits, dogs, swine, and humans [55][56][57].…”

Section: Discussionmentioning

confidence: 99%

Treatment Of Albino Rats With Oltipraz (4-MethyL-5-PyrazinyL-3H-1,2-Dithiole-3-Thione Protects Against Doxorubicin-Induced Cardiotoxicity

Jagetia¹,

Ramthianghlima²

2022

JCTR

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Doxorubicin is an anthracycline group of antibiotics that is frequently used in the treatment of various human neoplasias clinically. However, its adverse effect on the human heart is of major concern and limits its full clinical utilization. The present study was undertaken to alleviate the doxorubicin-induced myocardial toxicity by oltipraz an Nrf-2 inducer in albino rats. The albino rats were orally administered with 10 mg/kg body weight of oltipraz daily for three days before treatment with 15 mg/kg body weight of doxorubicin. The doxorubicininduced myocardial stress indicated by an increase in the CK-MB activity, and lipid peroxidation accompanied by a reduction in the glutathione, glutathione-s-transferase, catalase and superoxide dismutase in the rat heart. The administration of 10 mg/kg oltipraz for three days before doxorubicin treatment reduced the CK-MB activity and lipid peroxidation significantly followed by the significant elevation in the activities of glutathione-s-transferase, catalase and superoxide dismutase and glutathione in the rat heart. Our study demonstrates that oltipraz an Nrf-2 inducer reduced doxorubicin-induced myocardial stress in the rats.

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The Grape Fruit Bioflavonoid Naringin Protects Against the Doxorubicin-Induced Micronuclei Formation in Mouse Bone Marrow

Cited by 6 publications

References 44 publications

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Naringin, a Grape Fruit Bioflavonoid Protects Mice Bone Marrow Cells against the Doxorubicin-Induced Oxidative Stress

Treatment Of Albino Rats With Oltipraz (4-MethyL-5-PyrazinyL-3H-1,2-Dithiole-3-Thione Protects Against Doxorubicin-Induced Cardiotoxicity

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