The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection

Henß, Lisa; Auste, Arne; Schürmann, Christoph; Schmidt, Christin; Rhein, Christine von; Mühlebach, Michael D.; Schnierle, Barbara S.

doi:10.1099/jgv.0.001574

Cited by 112 publications

(114 citation statements)

References 50 publications

Supporting

Mentioning

107

Contrasting

Order By: Relevance

“…CoVs[23], was inhibited by EGCG treatment. Interestingly, EGCG was recently shown to significantly inhibit authentic SARS-CoV-2 infection, and time-of-addition experiments suggested that EGCG at least partially blocks SARS-CoV-2 entry[25], consistent with our findings. In this study, we expand the scope of EGCG activity to other CoVs, including murine and bat CoVs, and demonstrate the physiological relevance of the inhibitory activity of EGCG on CoV attachment and infection of lung epithelial cells.…”

supporting

confidence: 91%

“…Finally, recent studies have identified in vitro inhibitory effects of EGCG against the SARS-CoV-2 3C-like protease [34–37]. However, our time-of-addition experiments with HCoV-229E and HCoV-OC43, as well as those of others with SARS-CoV-2 [25], strongly suggest that EGCG predominantly inhibits authentic CoV infection by blocking entry, although other activities might be exerted at higher concentrations. Furthermore, we show that EGCG reduces cell surface binding of HCoV-OC43 and VSV-SARS-CoV-2, in a similar manner to heparin, which has been demonstrated to competitively block virion attachment [11].…”

Section: Discussionmentioning

confidence: 65%

See 1 more Smart Citation

The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus entry inhibitor

LeBlanc

Colpitts

2021

Preprint

View full text Add to dashboard Cite

The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emphasized the serious threat to human health posed by emerging coronaviruses. Effective antiviral countermeasures are urgently needed as vaccine development against an emerging coronavirus takes time, even in the best-case scenario. The green tea catechin, epigallocatechin gallate (EGCG), has broad spectrum antiviral activity. We demonstrate here that EGCG prevents murine and human coronavirus infection and blocks the entry of lentiviral particles pseudotyped with spike proteins from bat or highly pathogenic coronaviruses. We show that EGCG treatment reduces coronavirus attachment to target cell surfaces. Our results demonstrate the potential for the development of pan-coronavirus attachment inhibitors.

show abstract

supporting

confidence: 91%

Section: Discussionmentioning

confidence: 65%

The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus entry inhibitor

LeBlanc

Colpitts

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Despite several limitations, the findings of present study might help to elucidate on the mechanisms of action of the anti-viral effects of catechins in the oral cavity. Recent studies reported an inhibitory effect of EGCG on COVID-19, which has increased attention toward green tea as a non-pharmacological preventive measure [ 19 , 20 , 21 ]. Although there are still many unknowns regarding the clinical effects of catechins in humans, we believe that the results of this study will guide future research related to catechins and contribute to their further development toward enhancing human health.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Oral Retention of Tea Catechins in Humans: An Exploratory Interventional Study

et al. 2021

View full text Add to dashboard Cite

Green tea catechin ingestion or gargling exhibit anti-viral activity against upper respiratory infection. We hypothesized that retention in the oral cavity could improve the anti-viral effects of catechins. The present study investigated the oral retention of catechins in humans and the effect of catechin beverage viscosity on oral retention. Two intervention studies with different test beverages, beverage-C (40 mL, containing 73.4 mg of catechins) and beverage-XT (40 mL, beverage-C containing 100 mg xanthan gum) were conducted in 20 healthy volunteers (mean age 38.7 years). Catechin concentrations were measured in buccal mucosa samples collected at 10 min, 40 min, and 60 min after ingesting test beverages, and the catechin variability of the tissue after intake was compared between test beverages. As a result, the mean (SEM) concentrations of EGCG were 99.9 (27.2), 58.2 (16.6), and 22.3 (5.7) ng/mg-mucosa at 10, 40, and 60 min, respectively, after ingestion of beverage-XT. Similarly, the catechin concentrations were 86.1 (20.3), 32.2 (5.3), and 27.8 (5.9) ng/mg-mucosa after ingestion of beverage-C. The total retention volume over 60 min tended to be slightly higher after ingestion of beverage-XT, though the difference was not statistically significant. Additional studies are needed to confirm the effect of xanthan gum on improving oral retention of catechins.

show abstract

“…Epigallocatechin gallate (EGCG), an active constituent of green tea, has been identified as a potential inhibitor of the RBD domain and other proteins of SARS-CoV-2[ 37 ]. The effect of green tea consumption may be explored for inhibition of S protein domains to prevent its binding with ACE2[ 38 ]. This may be particularly effective in the gastrointestinal tract, as the oral route implies maximum availability in the digestive tract.…”

Section: Mechanisms Of Gastrointestinal Tract Involvementmentioning

confidence: 99%

COVID-19 and its effects on the digestive system

Cao¹,

Zhang²,

Pellegrini³

et al. 2021

WJG

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) is caused by infection of the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with typical respiratory symptoms. SARS-CoV-2 invades not only the respiratory system, but also other organs expressing the cell surface receptor angiotensin converting enzyme 2. In particular, the digestive system is a susceptible target of SARS-CoV-2. Gastrointestinal symptoms of COVID-19 include anorexia, nausea, vomiting, diarrhea, abdominal pain, and liver damage. Patients with digestive damage have a greater chance of progressing to severe or critical illness, a poorer prognosis, and a higher risk of death. This paper aims to summarize the digestive system symptoms of COVID-19 and discuss fecal-oral contagion of SARS-CoV-2. It also describes the characteristics of inflammatory bowel disease patients with SARS-CoV-2 infection and discusses precautions for preventing SARS-CoV-2 infection during gastrointestinal endoscopy procedures. Improved attention to digestive system abnormalities and gastrointestinal symptoms of COVID-19 patients may aid health care providers in the process of clinical diagnosis, treatment, and epidemic prevention and control.

show abstract

The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection

Cited by 112 publications

References 50 publications

The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus entry inhibitor

The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus entry inhibitor

Investigation of the Oral Retention of Tea Catechins in Humans: An Exploratory Interventional Study

COVID-19 and its effects on the digestive system

Contact Info

Product

Resources

About