The Grueneberg ganglion: signal transduction and coding in an olfactory and thermosensory organ involved in the detection of alarm pheromones and predator-secreted kairomones

Fleischer, Joerg

doi:10.1007/s00441-020-03380-w

Cited by 10 publications

(15 citation statements)

References 87 publications

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“…In this respect, birds step out of the line in the sense that, like fish, they have only one OS that resembles the main OS of mammalian species (32,36). In many mammalian species, the OS is made up of numerous anatomically, cellularly, and molecularly distinct subsystems, including the main OS, the accessory OS, the septal organ of Masera (SO), the Gr€ uneberg ganglion (GG), and the guanylate cyclase-D (GC-D) necklace system (see 25,37,38). The generic bauplans of these subsystems are remarkably similar, but they largely respond to different odorants, express different olfactory receptors, employ different transduction pathways, and connect to different higher brain centers (25,27).…”

Section: Principles Of Organization and Functioning Of Biological Olfactory Systemsmentioning

confidence: 99%

“…Receptor neurons of the GG do not have the typical morphology of canonical receptor neurons; they possess neither dendrites, olfactory cilia, or microvilli, nor do they seem to have direct access to the nasal lumen (25,34,37). Nevertheless, GG receptor neurons can be activated by odorants and have been reported to express OMP TAARs, V2Rs, ACIII, Ga olf , Ga o , or Ga i , the guanylate cyclase G (GC-G), and the potassium channel TREK-1 (34,37,153). The functional particularity of these cells is that they consistently respond to cool temperature (34,37,(272)(273)(274)(275)(276)(277).…”

Section: Transduction Mechanisms In Receptormentioning

confidence: 99%

“…Nevertheless, GG receptor neurons can be activated by odorants and have been reported to express OMP TAARs, V2Rs, ACIII, Ga olf , Ga o , or Ga i , the guanylate cyclase G (GC-G), and the potassium channel TREK-1 (34,37,153). The functional particularity of these cells is that they consistently respond to cool temperature (34,37,(272)(273)(274)(275)(276)(277).…”

Section: Transduction Mechanisms In Receptormentioning

confidence: 99%

“…GC-D-positive neurons have been shown to coexpress receptors encoded by the family of ms4A genes (38,149,150). GC-G is expressed in neurons of the main OE and the GG (37,349,350).…”

Section: Receptor Gene Familiesmentioning

confidence: 99%

“…5.2.4). Some OR-type olfactory receptors, TAARs, and V1Rs are also expressed in receptor neurons of the GG and SO (25,34,37).…”

Section: Olfactory Subsystem-specific Expressionmentioning

confidence: 99%

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Principles of odor coding in vertebrates and artificial chemosensory systems

Manzini

Schild

Natale

2022

Physiological Reviews

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The biological olfactory system is the sensory system responsible for the detection of the chemical composition of the environment. Several attempts to mimic biological olfactory systems have led to various artificial olfactory systems using different technical approaches. Here we provide a parallel description of biological olfactory systems and their technical counterparts. We start with a presentation of the input to the systems, the stimuli, and treat the interface between the external world and the environment where receptor neurons or artificial chemosensors reside. We then delineate the functions of receptor neurons and chemosensors as well as their overall I-O relationships. Up to this point, our account of the systems goes along similar lines. The next processing steps differ considerably: while in biology the processing step following the receptor neurons is the "integration" and "processing" of receptor neuron outputs in the olfactory bulb, this step has various realizations in electronic noses. For a long period of time, the signal processing stages beyond the olfactory bulb, i.e., the higher olfactory centers were little studied. Only recently there has been a marked growth of studies tackling the information processing in these centers. In electronic noses, a third stage of processing has virtually never been considered. In this review, we provide an up-to-date overview of the current knowledge of both fields and, for the first time, attempt to tie them together. We hope it will be a breeding ground for better information, communication, and data exchange between very related but so far little connected fields.

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Section: Principles Of Organization and Functioning Of Biological Olfactory Systemsmentioning

confidence: 99%

Section: Transduction Mechanisms In Receptormentioning

confidence: 99%

Section: Transduction Mechanisms In Receptormentioning

confidence: 99%

“…GC-D-positive neurons have been shown to coexpress receptors encoded by the family of ms4A genes (38,149,150). GC-G is expressed in neurons of the main OE and the GG (37,349,350).…”

Section: Receptor Gene Familiesmentioning

confidence: 99%

“…5.2.4). Some OR-type olfactory receptors, TAARs, and V1Rs are also expressed in receptor neurons of the GG and SO (25,34,37).…”

Section: Olfactory Subsystem-specific Expressionmentioning

confidence: 99%

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Principles of odor coding in vertebrates and artificial chemosensory systems

Manzini

Schild

Natale

2022

Physiological Reviews

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Epigenetic programming of stochastic olfactory receptor choice

Yusuf,

Monahan

2024

Genesis

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SummaryThe mammalian sense of smell relies upon a vast array of receptor proteins to detect odorant compounds present in the environment. The proper deployment of these receptor proteins in olfactory sensory neurons is orchestrated by a suite of epigenetic processes that remodel the olfactory genes in differentiating neuronal progenitors. The goal of this review is to elucidate the central role of gene regulatory processes acting in neuronal progenitors of olfactory sensory neurons that lead to a singular expression of an odorant receptor in mature olfactory sensory neurons. We begin by describing the principal features of odorant receptor gene expression in mature olfactory sensory neurons. Next, we delineate our current understanding of how these features emerge from multiple gene regulatory mechanisms acting in neuronal progenitors. Finally, we close by discussing the key gaps in our understanding of how these regulatory mechanisms work and how they interact with each other over the course of differentiation.

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Smelling the Basis of Social Connectedness: Chemosensory Communication in Humans

Pause

2023

Chemical Signals in Vertebrates 15

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The Grueneberg ganglion: signal transduction and coding in an olfactory and thermosensory organ involved in the detection of alarm pheromones and predator-secreted kairomones

Cited by 10 publications

References 87 publications

Principles of odor coding in vertebrates and artificial chemosensory systems

Principles of odor coding in vertebrates and artificial chemosensory systems

Epigenetic programming of stochastic olfactory receptor choice

Smelling the Basis of Social Connectedness: Chemosensory Communication in Humans

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