The Guillain-Barré Syndrome, A Personal Experience

Henschel, Ernest O.

doi:10.1097/00000542-197708000-00013

Cited by 26 publications

(4 citation statements)

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“…[39] It is managed with frequent changes in position, NSAIDs and narcotics. [39,40] Antidepressants may be used as an adjuvant to manage sleep disturbances, parasthetic pain and emotional consequences of the illness. [41] Twenty three (39%) patients complained of pain.…”

Section: Discussionmentioning

confidence: 99%

Intensive care management of Guillain-Barre syndrome: A retrospective outcome study and review of literature

Bhagat

Dash

Chauhan

et al. 2014

Journal of Neuroanaesthesiology and Critical Care

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Introduction: Guillain-Barre syndrome (GBS) is an immune mediated disorder which is associated with demyelination of peripheral nervous system and progressive muscle weakness. Severely affected patients have respiratory dysfunction and may need ventilatory support which can cause significant morbidity and mortality. There is limited Indian data with regards to the outcome of severely affected GBS patients. The present study reflects the intensive care management of severely affected GBS patients at neurological centre of a tertiary care institute of India. Materials and Methods: The study was designed to retrospectively review the patient records who were admitted to neurological intensive care unit (ICU) of AIIMS, New Delhi. The epidemiology, clinical features, course of management and outcome of GBS patients admitted between April 2000 to December 2005 were recorded and analysed. Results: The data of 59 patients were available for inclusion in the study. The mean age of patients admitted to neurological ICU was 35 years with male preponderance. Ventilatory failure was the most common indication for ICU admission. 95% patients required ventilatory support for a mean duration of 30 days. The mortality data included 60 patients and 13 patients died during the course of management. Conclusions: The present study indicates that severely affected GBS patients may need prolonged mechanical ventilation. Despite management in a specialized neurological ICU the mortality can be as high as 21%.

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Section: Discussionmentioning

confidence: 99%

Intensive care management of Guillain-Barre syndrome: A retrospective outcome study and review of literature

Bhagat

Dash

Chauhan

et al. 2014

Journal of Neuroanaesthesiology and Critical Care

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“…Il faut rechercher la douleur plus particulièrement chez les patients intubés. Il convient d'insister sur le caractère opérateur-dépendant des aspirations trachéales [8,14,15]. Certains auteurs ont proposé l'administration d'oxygène lors des aspirations trachéales par l'intermédiaire d'une sonde mixte assurant oxygénation et aspiration de façon concomitante [16].…”

Section: Discussionunclassified

Perception par les patients de leur séjour en réanimation

et al. 2007

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“…This is possibly due to the differing properties of the two drugs; alfentanil, being an opioid with some sedative properties, does not appear to relieve anxiety. Reports from former patients indicate that the use of sedative drugs alone is not always the most appropriate or desirable way to relieve distress [16,17]. After the infusion was stopped, recovery was rapid -despite total doses in excess of 50 rag.…”

Section: Discussionmentioning

confidence: 99%

Alfentanil infusions on the intensive therapy unit

et al. 1988

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We have investigated the use of alfentanil by infusion to sedate 14 patients during controlled ventilation on the intensive therapy unit (ITU). An initial rate of 24 micrograms.kg-1.h-1 was chosen and altered thereafter according to patient response. Incremental doses of midazolam (2.5-5.0 mg) were given intravenously (i.v.) if indicated. In 4 patients, the use of a muscle relaxant was necessary to allow adequate controlled ventilation of the patient. The mean duration of infusion was 27.9 h (range 10-141 h), and the mean total dose of alfentanil was 69.3 mg (12.5-240 mg). Spontaneous ventilation was rapidly achieved in 11 patients after stopping the infusion. The mean arterial carbon dioxide tension (PaCO2) was 5.38 kPa, 15-30 min after stopping the infusion. The clinical condition of 2 patients necessitated a change in sedation technique and one patient died during the alfentanil infusion. Alfentanil by infusion caused no major cardiovascular effects and did not influence the plasma cortisol response to trauma. There was no major alteration in blood biochemistry or haematology during the infusions of alfentanil. The plasma concentrations of alfentanil during infusion showed a wide variability. These probably relate to both changes in the volume of distribution of the drug and in hepatic clearance.

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The Guillain-Barré Syndrome, A Personal Experience

Cited by 26 publications

References 0 publications

Intensive care management of Guillain-Barre syndrome: A retrospective outcome study and review of literature

Intensive care management of Guillain-Barre syndrome: A retrospective outcome study and review of literature

Perception par les patients de leur séjour en réanimation

Alfentanil infusions on the intensive therapy unit

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