The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases

Jiang, Zengliang; Zhuo, Lai-Bao; He, Yan; Fu, Yuanqing; Shen, Luqi; Xu, Fengzhe; Gou, Wanglong; Miao, Zelei; Shuai, Menglei; Liang, Yuhui; Xiao, Congmei; Liang, Xiubo; Tian, Yunyi; Wang, Jiali; Tang, Jun; Deng, Kui; Zhou, Hongwei; Chen, Yu Ming; Zheng, Ju‐Sheng

doi:10.1038/s41467-022-30712-x

Cited by 75 publications

(48 citation statements)

References 80 publications

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“…Secondary bile acids such as DCA and LCA are positively correlated with the abundance of members of the Firmicutes such as Clostridiales, Enterococcaceae, Eubacteriaceae, Lachnospiraceae, and Ruminococcaceae in the gut and negatively correlated with the abundance of Enterococcus, Lactobacillus, and others (Connors et al, 2020;Li et al, 2021;Yang et al, 2021). Jiang et al found that Ruminococcaceae UCG-002 and UCG-003 are positively correlated with secondary bile acids (IsoLCA, LCA and UDCA) and negatively correlated with primary bile acids (MCA and NorCA) in chronic insomnia and cardiometabolic disease (Jiang et al, 2022). In addition, Wei et al, in a study of obesity susceptibility, found that Clostridium scindens is positively correlated with LCA, DCA, and UDCA and that Clostridium hylemonae is significantly positively correlated with UDCA (Wei et al, 2020).…”

Section: The Gut Microbiota-bile Acid Axismentioning

confidence: 99%

“…The interaction between the gut microbiota and bile acids is complex and bidirectional in the host, known as the gut microbiota–bile acid axis ( Hou et al., 2021 ; Wu et al., 2021b ; Jiang et al., 2022 ). The gut microbiota can transform and modify bile acids, influence bile acid production, and alter bile acid receptor signaling.…”

Section: The Gut Microbiota–bile Acid Axis In Liver Fibrosismentioning

confidence: 99%

“…Jiang et al. found that Ruminococcaceae UCG-002 and UCG-003 are positively correlated with secondary bile acids (IsoLCA, LCA and UDCA) and negatively correlated with primary bile acids (MCA and NorCA) in chronic insomnia and cardiometabolic disease ( Jiang et al., 2022 ). In addition, Wei et al., in a study of obesity susceptibility, found that Clostridium scindens is positively correlated with LCA, DCA, and UDCA and that Clostridium hylemonae is significantly positively correlated with UDCA ( Wei et al., 2020 ).…”

Section: The Gut Microbiota–bile Acid Axis In Liver Fibrosismentioning

confidence: 99%

“…In the intestine, primary bile acids are biotransformed into secondary bile acids by enzymes produced by the gut microbiota via deconjugation, dehydroxylation, oxidation and isomerization, esterification and desulfation reactions ( Pavlidis et al., 2015 ; Thomas et al., 2022 ). Bacteria with bile salt hydrolase activity ( Bacteroides, Clostridium, Lactobacillus, Bifidobacterium , Enterococcus, Ruminococcaceae , and Listeria ) dominate the bile acid deconjugation process ( Ridlon et al., 2006 ; Long et al., 2017 ; Guzior and Quinn, 2021 ; Jiang et al., 2022 ; Thomas et al., 2022 ). Furthermore, hydroxysteroid dehydrogenases produced by the gut microbiota such as Clostridium are necessary for catalyzing the oxidation, isomerization, and dehydroxylation of bile acids ( Guzior and Quinn, 2021 ).…”

Section: The Gut Microbiota–bile Acid Axis In Liver Fibrosismentioning

confidence: 99%

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The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis

Zhang

Gou

et al. 2022

Front. Cell. Infect. Microbiol.

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Liver fibrosis involves the proliferation and deposition of extracellular matrix on liver tissues owing to various etiologies (including viral, alcohol, immune, and metabolic factors), ultimately leading to structural and functional abnormalities in the liver. If not effectively treated, liver fibrosis, a pivotal stage in the path to chronic liver disease, can progress to cirrhosis and eventually liver cancer; unfortunately, no specific clinical treatment for liver fibrosis has been established to date. In liver fibrosis cases, both the gut microbiota and bile acid metabolism are disrupted. As metabolites of the gut microbiota, bile acids have been linked to the progression of liver fibrosis via various pathways, thus implying that the gut microbiota–bile acid axis might play a critical role in the progression of liver fibrosis and could be a target for its reversal. Therefore, in this review, we examined the involvement of the gut microbiota–bile acid axis in liver fibrosis progression to the end of discovering new targets for the prevention, diagnosis, and therapy of chronic liver diseases, including liver fibrosis.

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Section: The Gut Microbiota-bile Acid Axismentioning

confidence: 99%

Section: The Gut Microbiota–bile Acid Axis In Liver Fibrosismentioning

confidence: 99%

Section: The Gut Microbiota–bile Acid Axis In Liver Fibrosismentioning

confidence: 99%

Section: The Gut Microbiota–bile Acid Axis In Liver Fibrosismentioning

confidence: 99%

See 2 more Smart Citations

The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis

Zhang

Gou

et al. 2022

Front. Cell. Infect. Microbiol.

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“…And the acute circadian rhythm disturbance caused by sleep-wake shifts affect the human gut microbiota (75), especially the functional profiles of gut microbes and interactions among them. Thus, the gut microbiome is a potential target for reducing the impact of chronic insomnia on cardiometabolic health (76). Due to a causal relationship between the gut microbiome and hypertension (77), the former may be a target for treatment of OSA-related and other typical hypertension.…”

Section: Mechanisms Mediated By Sleep and Microbiomementioning

confidence: 99%

The “brain-heart-gut” axis and novel mechanisms of future cardiovascular disease

2022

Preprint

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Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in the globe. Both established cardiovascular disease (eCVD) and future CVD (fCVD) need to further explore the mechanisms. This article briefly introduces current major studies on axis and CVD, which were published in cardiovascular journals and non-cardiovascular journals (Table 1 & Table 2), and brings up and discusses the new origins of fCVD linking to major risk factors in early life due to unhealthy “environment-sleep-emotion-exercise-diet” intervention [E(e)SEEDi] lifestyle referred as to a “Golden Hoop Curse”, and the “brain-heart-gut” axis—a fresh theory on novel mechanisms of fCVD (Figure 1 & Figure 2), which are mediated by E(e)SEEDi lifestyle and microbiome. As a new theory, the “brain-heart-gut” axis will help us to earlier and better prevent and control both eCVD and fCVD with healthy E(e)SEEDi lifestyle.

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Diet Mediate the Impact of Host Habitat on Gut Microbiome and Influence Clinical Indexes by Modulating Gut Microbes and Serum Metabolites

Zhang,

Qi,

et al. 2024

Advanced Science

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The impact of external factors on the human gut microbiota and how gut microbes contribute to human health is an intriguing question. Here, the gut microbiome of 3,224 individuals (496 with serum metabolome) with 109 variables is studied. Multiple analyses reveal that geographic factors explain the greatest variance of the gut microbiome and the similarity of individuals’ gut microbiome is negatively correlated with their geographic distance. Main food components are the most important factors that mediate the impact of host habitats on the gut microbiome. Diet and gut microbes collaboratively contribute to the variation of serum metabolites, and correlate to the increase or decrease of certain clinical indexes. Specifically, systolic blood pressure is lowered by vegetable oil through increasing the abundance of Blautia and reducing the serum level of 1‐palmitoyl‐2‐palmitoleoyl‐GPC (16:0/16:1), but it is reduced by fruit intake through increasing the serum level of Blautia improved threonate. Besides, aging‐related clinical indexes are also closely correlated with the variation of gut microbes and serum metabolites. In this study, the linkages of geographic locations, diet, the gut microbiome, serum metabolites, and physiological indexes in a Chinese population are characterized. It is proved again that gut microbes and their metabolites are important media for external factors to affect human health.

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The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases

Cited by 75 publications

References 80 publications

The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis

The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis

The “brain-heart-gut” axis and novel mechanisms of future cardiovascular disease

Diet Mediate the Impact of Host Habitat on Gut Microbiome and Influence Clinical Indexes by Modulating Gut Microbes and Serum Metabolites

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