The gut microbiota–brain axis in behaviour and brain disorders

Morais, Lívia H.; Schreiber, Henry L.; Mazmanian, Sarkis K.

doi:10.1038/s41579-020-00460-0

Cited by 1,269 publications

(936 citation statements)

References 168 publications

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“…We also confirm that these alternations are transient and there exist the neuroprotective effect of probiotics against intestinal dysbacteriosis. Furthermore, gut microbiota can produce neuroactive compounds such as neurotransmitters including noradrenaline, γ-aminobutyric acid (GABA), dopamine and serotonin [ 32 ]. Thus, it is possible that the changed neurotransmitter release are involved in various neurological disorders caused by antibiotics treatment, which would be further explored in our future study.…”

Section: Discussionmentioning

confidence: 99%

Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice

Wang

Cao

et al. 2021

Mol Brain

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Antibiotics affect gut microbial composition, leading to Gut–Brain-Axis imbalance and neurobehavioral changes. However, the intestinal dysbacteriosis associated behavior changes are not consistently reported. It is not clear whether these changes are transient or permanent. The neuroprotective effect of probiotics against intestinal dysbacteriosis induced alternations needs to be determined either. In the present study, oral antibiotic mixture including Ampicillin, Streptomycin, and Clindamycin was utilized to induce intestinal dysbacteriosis in mice. Antibiotics application triggered mechanical allodynia in von frey test and spontaneous pain in open field test. It also resulted in increased anxiety and depressive-like behaviors and damaged spatial memory performance. After application of probiotics, the mechanical allodynia and spontaneous pain were alleviated significantly. The anxiety behaviors, depressive-like behaviors and recognitive performance were ameliorative as well. By using Fos protein as a marker, it is found that the sensory, emotion and memory related brain regions were activated in mice with intestinal dysbacteriosis. Our study is not only helpful for enriching our basic knowledge for understanding the changed pain responses and related brain disorders in antibiotics-induced dysbacteriosis mice, but also beneficial for providing a more comprehensive mechanistic explanation for the regulation of antibiotics and probiotics on gut microbiota and relevant alternations in animal neurological behaviors.

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Section: Discussionmentioning

confidence: 99%

Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice

Wang

Cao

et al. 2021

Mol Brain

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“…Microglia and systemic cytokines (inflammatory level) have key mediating effects. These pathways may be involved in the pathogenesis of neurodegenerative diseases and other neuro related diseases ( Morais et al, 2020 ).…”

Section: Gm and Neurodegenerative Diseasesmentioning

confidence: 99%

Role and Mechanism of Gut Microbiota in Human Disease

Chen

Zhou

Wang

2021

Front. Cell. Infect. Microbiol.

320

187

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The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic diseases. The underlying mechanisms of GM on human diseases are incredibly complicated. This review focuses on the regulation and mechanism of GM on neurodegenerative diseases, cardiovascular diseases, metabolic diseases and gastrointestinal diseases, thus providing a potential target for the prevention and treatment of disease.

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“…Although metagenomics has revolutionized the perception of the human microbiome and metabolomic analyses have contributed to the identification of derived metabolites acting on host cells, it remains important to better differentiate the strain-specificity among species and to decipher the functional properties of the bacterial community. Some correlation studies, comparing the microbiomes of patients and healthy individuals highlighted the association between dysbiosis and many chronic non-communicable diseases, notably metabolic syndrome, obesity [ 22 , 23 ], diabetes [ 24 ], inflammatory bowel diseases [ 25 , 26 ], liver diseases [ 27 , 28 ], and neurodegenerative and psychiatric disorders [ 29 , 30 ]. These works concluded on the importance of the diversity of the intestinal microbiota and a sustainable cross-talk between the microbiota and its host for healthy status.…”

Section: Introductionmentioning

confidence: 99%

Identification of New Potential Biotherapeutics from Human Gut Microbiota-Derived Bacteria

et al. 2021

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The role of the gut microbiota in health and disease is well recognized and the microbiota dysbiosis observed in many chronic diseases became a new therapeutic target. The challenge is to get a better insight into the functionality of commensal bacteria and to use this knowledge to select live biotherapeutics as new preventive or therapeutic products. In this study, we set up a screening approach to evaluate the functional capacities of a set of 21 strains isolated from the gut microbiota of neonates and adults. For this purpose, we selected key biological processes involved in the microbiome-host symbiosis and known to impact the host physiology i.e., the production of short-chain fatty acids and the ability to strengthen an epithelial barrier (Caco-2), to induce the release of the anti-inflammatory IL-10 cytokine after co-culture with human immune cells (PBMC) or to increase GLP-1 production from STC-1 endocrine cell line. This strategy highlighted fifteen strains exhibiting beneficial activities among which seven strains combined several of them. Interestingly, this work revealed for the first time a high prevalence of potential health-promoting functions among intestinal commensal strains and identified several appealing novel candidates for the management of chronic diseases, notably obesity and inflammatory bowel diseases.

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The gut microbiota–brain axis in behaviour and brain disorders

Cited by 1,269 publications

References 168 publications

Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice

Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice

Role and Mechanism of Gut Microbiota in Human Disease

Identification of New Potential Biotherapeutics from Human Gut Microbiota-Derived Bacteria

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