The H+ Transporter SLC4A11: Roles in Metabolism, Oxidative Stress and Mitochondrial Uncoupling

Bonanno, Joseph A.; Shyam, Rajalekshmy; Choi, Moonjung; Ogando, Diego G.

doi:10.3390/cells11020197

Cited by 15 publications

(15 citation statements)

References 69 publications

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“…Nfe2l2 regulates not only circadian clock loops, especially Cry2 and metabolic signals but is known to be a key factor for anti‐oxidative and anti‐inflammatory properties (Wible et al, 2018; Yamawaki, 2022), mitochondrial homeostasis (Zhuang et al, 2022), H + transport (Bonanno et al, 2022), redox‐sensitivity (Li et al, 2021), and redox‐sensitive potassium channels (Ishii et al, 2013) in kidney tissues. Another transcriptional factor, PPARG, has an important role in the circadian rhythm by counteraction with Per2 (Bae et al, 2001; Duszka & Wahli, 2020) as well as in kidney function (Corrales et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

PPARG agonist pioglitazone influences diurnal kidney medulla mRNA expression of core clock, inflammation‐, and metabolism‐related genes disrupted by reverse feeding in mice

Izmailova¹,

Kabaliei²,

Shynkevych³

et al. 2022

Physiological Reports

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This study examined the influence of PPARG activation by pioglitazone (PG) on the mRNA of core clock, inflammation‐ and metabolism‐related genes in the mouse kidney medulla as well as urinary sodium/potassium excretion rhythms disrupted by reverse feeding. Mice were assigned to daytime feeding and nighttime feeding groups. PG 20 mg/kg was administered at 7 am or 7 pm . On day 8 of the feeding intervention, mice were killed at noon and midnight. Kidney medulla expression of Arntl, Clock, Nr1d1, Cry1, Cry2, Per1, Per2, Nfe2l2, Pparg , and Scnn1g was determined by qRT PCR. We measured urinary K + , Na + , urine volume, food, and H 2 O intake. The reverse feeding uncoupled the peripheral clock gene rhythm in mouse kidney tissues. It was accompanied by a decreased expression of Nfe2l2 and Pparg as well as an increased expression of Rela and Scnn1g. These changes in gene expressions concurred with an increase in urinary Na + , K + , water excretion, microcirculation disorders, and cell loss, especially in distal tubules. PG induced the restoration of diurnal core clock gene expression as well as Nfe2l2, Pparg , Scnn1g mRNA, and decreased Rela expressions, stimulating Na + reabsorption and inhibiting K + excretion. PG intake at 7 pm was more effective than at 7 am .

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Section: Discussionmentioning

confidence: 99%

PPARG agonist pioglitazone influences diurnal kidney medulla mRNA expression of core clock, inflammation‐, and metabolism‐related genes disrupted by reverse feeding in mice

Izmailova¹,

Kabaliei²,

Shynkevych³

et al. 2022

Physiological Reports

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“…Apoptosis and mitochondrial dysfunction are instead encouraged by SERPINC1 knockout because it activates the Bax pathway [ 107 ]. In the mitochondrial anti-oxidative system, SLC4 (solute carrier 4) scavenges ROS to improve radioresistance [ 108 ]. Hence, SERPINC1 and SLC4 may enhance radioresistance by enhancing mitochondrial metabolism and their capacity to scavenge ROS molecules.…”

Section: Enhancing the Normal Cells’ Mitochondria Reduces The Radioth...mentioning

confidence: 99%

Mitochondrial Metabolism: A New Dimension of Personalized Oncology

Behnam

Taghizadeh‐Hesary

2023

Cancers

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Energy is needed by cancer cells to stay alive and communicate with their surroundings. The primary organelles for cellular metabolism and energy synthesis are mitochondria. Researchers recently proved that cancer cells can steal immune cells’ mitochondria using nanoscale tubes. This finding demonstrates the dependence of cancer cells on normal cells for their living and function. It also denotes the importance of mitochondria in cancer cells’ biology. Emerging evidence has demonstrated how mitochondria are essential for cancer cells to survive in the harsh tumor microenvironments, evade the immune system, obtain more aggressive features, and resist treatments. For instance, functional mitochondria can improve cancer resistance against radiotherapy by scavenging the released reactive oxygen species. Therefore, targeting mitochondria can potentially enhance oncological outcomes, according to this notion. The tumors’ responses to anticancer treatments vary, ranging from a complete response to even cancer progression during treatment. Therefore, personalized cancer treatment is of crucial importance. So far, personalized cancer treatment has been based on genomic analysis. Evidence shows that tumors with high mitochondrial content are more resistant to treatment. This paper illustrates how mitochondrial metabolism can participate in cancer resistance to chemotherapy, immunotherapy, and radiotherapy. Pretreatment evaluation of mitochondrial metabolism can provide additional information to genomic analysis and can help to improve personalized oncological treatments. This article outlines the importance of mitochondrial metabolism in cancer biology and personalized treatments.

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“…In effect, in both mice [ 57 , 58 ] and humans [ 59 ], the alteration in anhydrase activity results in reduced sperm motility. Finally, there are discrepancies about the type of solutes transported by SLC4A11 or BTR1, as it could act as either an electrogenic Na + /B(OH) 4 − cotransporter or an electrogenic H + transporter activated by NH 3 and alkaline pH [ 60 ].…”

Section: Bicarbonate Transportersmentioning

confidence: 99%

A Review on the Role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals

Delgado-Bermúdez

Yeste

Bonet

et al. 2022

IJMS

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Alkalinization of sperm cytosol is essential for plasma membrane hyperpolarization, hyperactivation of motility, and acrosomal exocytosis during sperm capacitation in mammals. The plasma membrane of sperm cells contains different ion channels implicated in the increase of internal pH (pHi) by favoring either bicarbonate entrance or proton efflux. Bicarbonate transporters belong to the solute carrier families 4 (SLC4) and 26 (SLC26) and are currently grouped into Na+/HCO3− transporters and Cl−/HCO3− exchangers. Na+/HCO3− transporters are reported to be essential for the initial and fast entrance of HCO3− that triggers sperm capacitation, whereas Cl−/HCO3− exchangers are responsible for the sustained HCO3− entrance which orchestrates the sequence of changes associated with sperm capacitation. Proton efflux is required for the fast alkalinization of capacitated sperm cells and the activation of pH-dependent proteins; according to the species, this transport can be mediated by Na+/H+ exchangers (NHE) belonging to the SLC9 family and/or voltage-gated proton channels (HVCN1). Herein, we discuss the involvement of each of these channels in sperm capacitation and the acrosome reaction.

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The H+ Transporter SLC4A11: Roles in Metabolism, Oxidative Stress and Mitochondrial Uncoupling

Cited by 15 publications

References 69 publications

PPARG agonist pioglitazone influences diurnal kidney medulla mRNA expression of core clock, inflammation‐, and metabolism‐related genes disrupted by reverse feeding in mice

PPARG agonist pioglitazone influences diurnal kidney medulla mRNA expression of core clock, inflammation‐, and metabolism‐related genes disrupted by reverse feeding in mice

Mitochondrial Metabolism: A New Dimension of Personalized Oncology

A Review on the Role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals

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