The Haemodynamic Effects of Quazodine, a Cardiac Stimulant, in Experimental E. Coli Endotoxin Shock in the Cat

Parratt, J. R.; Winslow, E.

doi:10.1111/j.1440-1681.1974.tb00524.x

Cited by 59 publications

(2 citation statements)

References 23 publications

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“…This modification of the effects of a cardiac stimulant by endotoxin is not restricted to monensin. It occurs with other cardiac stimulants, such as the catecholamines (Parratt 1973), glucagon (Bower et a1 1970) and the phosphodiesterase inhibitor quazodine (Parratt & Winslow 1974). All these drugs probably act by increasing intracellular levels of CAMP, either by activating adenylate cyclase (catecholamines, glucagon) or by inhibiting CAMP breakdown (quazodine).…”

Section: Discussionmentioning

confidence: 99%

Haemodynamic effects of the carboxylic ionophore monensin when administered before and during shock induced by E. coli endotoxin

McCaig

Parratt

1979

Journal of Pharmacy and Pharmacology

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The haemodynamic effects of the carboxylic ionophore monensin have been examined in cats anaesthetized with sodium pentobarbitone. Marked increases in left ventricular dP/dtmax (and dP/dt at fixed isovolumic pressures) and slight increases in cardiac output and stroke volume occurred, indicating increased myocardial contractility. Heart rate was unchanged but systemic arterial pressure was substantially increased. Satisfactory increases in contractility and arterial pressure were obtained when monensin was infused intravenously in a total dose of 0·25 mg kg−1 over 10 min. Larger doses, especially if rapidly injected, resulted in very marked increases in myocardial contractility leading eventually to cardiac failure. The haemodynamic effects of monensin were markedly reduced during shock induced by E. coli endotoxin and there was unfortunately no evidence to suggest that this extremely potent compound might be potentially beneficial in this form of profound cardiovascular shock.

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Section: Discussionmentioning

confidence: 99%

Haemodynamic effects of the carboxylic ionophore monensin when administered before and during shock induced by E. coli endotoxin

McCaig

Parratt

1979

Journal of Pharmacy and Pharmacology

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“…There may therefore be changes in the sensitivity of myocardial /31-adrenoceptors in shock states. The stimulant actions of two other agents, quazodine (Parratt & Winslow, 1974) effects on fi-adrenoceptors but are both thought to increase cellular cyclic adenosine 3'-5'-monophosphate (cyclic AMP) levels. It is thus possible that the ability of myocardial cells to generate cyclic AMP is reduced during shock.…”

Section: Introductionmentioning

confidence: 99%

A COMPARISON OF THE CARDIOVASCULAR EFFECTS OF DOBUTAMINE AND A NEW DOPAMINE DERIVATIVE (D4975) DURING SHOCK INDUCED BY E. Coli ENDOTOXIN

McCaig

Parratt

1980

British J Pharmacology

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1 The effects of a newly developed dopamine-xanthine derivative, 7-propyl-theophylline-dopamine (D4975) and of dobutamine have been examined in anaesthetized cats before and after the induction of shock with E. coli endotoxin. 2 Both D4975 and dobutamine caused dose-related increases in left ventricular (LV) dP/dtmax (and LVdP/dt at fixed isovolumic pressures. Significantly smaller increases in LVdP/dtmax occurred as early as 0.5 to 1 h after endotoxin, with maximal attenuation at 1 to 2 h and some improvement in sensitivity in cats surviving 2 to 4 h. The maximum response to each drug was markedly reduced in shock. 3 Neither D4975 nor dobutamine had significant effects on heart rate. D4975 caused dose-related increases in systemic arterial blood pressure which were smaller during shock, the changes in responsiveness following those in LVdP/dtmax. 4 Possible mechanisms responsible for changing myocardial sensitivity to these and other agents are discussed. It is concluded that D4975 may be more useful in the treatment of shock than either dopamine or dobutamine because (a) it is more potent during shock than dobutamine (perhaps as a result of phosphodiesterase inhibition by the theophylline component of D4975); (b) its action is longer-lasting than dobutamine or dopamine and (c) like dobutamine, its effect on heart rate is insignificant.

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Changes in intestinal blood flow during the development of chronic large bowel obstruction

Coxon

Dickson

Taylor

1984

Journal of British Surgery

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The effect of chronic progressive distal large bowel obstruction on intestinal blood flow was studied in 12 mini-pigs. Blood flow was measured by the techniques of xenon133 clearance and intracardiac injections of radiolabelled microspheres. Intestinal blood flow was increased in the left colon and ileum but decreased in the caecum. Blood was shunted from the mucosa to the muscle layers. The results suggest that primary anastomosis of the obstructed left colon is not contraindicated by haemodynamic considerations.

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The Haemodynamic Effects of Quazodine, a Cardiac Stimulant, in Experimental E. Coli Endotoxin Shock in the Cat

Cited by 59 publications

References 23 publications

Haemodynamic effects of the carboxylic ionophore monensin when administered before and during shock induced by E. coli endotoxin

Haemodynamic effects of the carboxylic ionophore monensin when administered before and during shock induced by E. coli endotoxin

A COMPARISON OF THE CARDIOVASCULAR EFFECTS OF DOBUTAMINE AND A NEW DOPAMINE DERIVATIVE (D4975) DURING SHOCK INDUCED BY E. Coli ENDOTOXIN

Changes in intestinal blood flow during the development of chronic large bowel obstruction

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