The Haemodynamics of Endovascular Aneurysm Treatment: A Computational Modelling Approach for Estimating the Influence of Multiple Coil Deployment

Kakalis, Nikolaos M.P.; Mitsos, Aristotelis P.; Byrne, James; Ventikos, Yiannis

doi:10.1109/tmi.2008.915549

Cited by 77 publications

(64 citation statements)

References 28 publications

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“…[19][20][21][22][23] Using state-of-the-art techniques, several studies have reported the influence of blood flow on the results of coil embolization for intracranial aneurysms. [24][25][26][27][28][29] In this study, we investigated the hemodynamics of basilar tip aneurysms with special attention to the volume of blood flow into aneurysms through the neck. In addition, we examined the correlation between the configuration of the parent arteries and the proportion of blood flow entering into the aneurysms.…”

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confidence: 99%

Blood Flow Into Basilar Tip Aneurysms

Sugiyama

Niizuma

Sato

et al. 2016

Stroke

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We retrospectively investigated the clinical and radiological data from 111 consecutive patients who underwent endovascular treatment Background and Purpose-Hemodynamic forces may play a role in the recanalization of coiled aneurysms. The purpose of this study was to investigate the influence of presurgical hemodynamics on the efficacy of coil embolization for basilar tip aneurysms. Methods-We identified 82 patients who underwent endovascular coil embolization for basilar tip aneurysms with a followup of >1 year. Presurgical hemodynamics were investigated using computational fluid dynamics with 3-dimensional data derived from rotational angiography. During postprocessing, we quantified the rate of net flow entering the aneurysm through its neck and calculated the proportion of the aneurysmal inflow rate to the basilar artery flow rate. In addition, we investigated the correlation between the basilar bifurcation configuration and the hemodynamics. Results-Twenty-five of the 82 patients were excluded because of difficult vascular geometry reconstruction. Among the 57 examined patients, angiographic recanalization was observed in 19 patients (33.3%). The proportion of the aneurysmal inflow rate to the basilar artery flow rate and a coil packing density <30% were independent and significant predictors for the recanalization of coiled aneurysms. Additional investigation revealed that a small branch angle formed by the basilar artery and the posterior cerebral artery increased blood flow into the aneurysm. Conclusions-The proportion of the aneurysmal inflow rate to the basilar artery flow rate, influenced by the basilar bifurcation configuration, was an independent and significant predictor for recanalization after coil embolization in basilar tip aneurysms.

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confidence: 99%

Blood Flow Into Basilar Tip Aneurysms

Sugiyama

Niizuma

Sato

et al. 2016

Stroke

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“…[2][3][4] CFD simulations have been used to gain insight into the patient-specific hemodynamics and could potentially assist rupture-risk assessment [5][6][7][8][9] and treatment planning. [10][11][12][13][14][15][16] Vascular models can be constructed through segmentation of 3DRA and CTA images. Compared with CTA, 3DRA produces images with higher contrast, higher spatial resolution, and lower visibility of bone, [17][18][19] which lead to better segmentation results 20 and superior anatomic accuracy.…”

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confidence: 99%

Patient-Specific Computational Hemodynamics of Intracranial Aneurysms from 3D Rotational Angiography and CT Angiography: An In Vivo Reproducibility Study

Geers¹,

Larrabide²,

Radaelli³

et al. 2010

AJNR Am J Neuroradiol

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“…1). Coil bundles can be modeled as a porous zone in order to study intra-aneurysmal flow characteristics (19) (20) . However, we assumed the coil had been embolized and the porous zone between coils was filled with soft clots.…”

Section: Aneurysm Modelsmentioning

confidence: 99%

“…The hemodynamics of partially blocked aneurysms have been analyzed using a computational fluid dynamics (CFD) method (17) (18) . Furthermore, intra-aneurysmal hemodynamics have been investigated computationally by modeling coils as a porous medium (19) (20) . Thromboembolization inside the coils was simulated using a viscosity model, which was defined as a function of both residence time and clotting fluid concentration (21) .…”

Section: Introductionmentioning

confidence: 99%

Effects of Coil Bundle Deformation on Intra-Aneurysmal Flow

Jeong¹,

Han

Rhee³

2012

JBSE

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Aneurysm recanalization can be attributed to coil compaction and migration, which are affected by hemodynamic forces acting on the packed coil inside the aneurysm. The effects of coil bundle deformation on the hemodynamic changes in coil-inserted lateral aneurysm models were investigated using computational fluid dynamics methods incorporating fluid-structure interactions. Lateral aneurysms with normal and wide necks were modeled, and coil bundles were modeled as elastic spheres. The time-averaged mean velocity magnitude at the neck (MVN) and the time-averaged mean kinetic energy (MKE) were calculated to quantify the overall inflow strength and intra-aneurysmal flow activity, respectively. The MVNs and MKEs were higher in elastic coil models than in rigid models, and elastic coil models with lower Young's moduli had higher MVNs. Therefore, coil deformation caused by hemodynamic forces is suspected to provide an unfavorable hemodynamic environment for aneurysm embolization.

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The Haemodynamics of Endovascular Aneurysm Treatment: A Computational Modelling Approach for Estimating the Influence of Multiple Coil Deployment

Cited by 77 publications

References 28 publications

Blood Flow Into Basilar Tip Aneurysms

Blood Flow Into Basilar Tip Aneurysms

Patient-Specific Computational Hemodynamics of Intracranial Aneurysms from 3D Rotational Angiography and CT Angiography: An In Vivo Reproducibility Study

Effects of Coil Bundle Deformation on Intra-Aneurysmal Flow

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