The notion that the world has been witnessing a profound neoliberal transformation since around the 1980s onward is widely accepted in many parts of social science and the humanities. Moreover, the overarching impression is that this transformation has mostly been regrettable in economic, political, and other social terms. At the same time, careful interdisciplinary research recently uncovered that neoliberalism has been notoriously hard to define. Based on that research, this article first clarifies the conceptual confusion surrounding neoliberalism and presents a broad, synthetic institutions-based working definition of it that captures its typical contemporary usages. The article then asks if a systematic empirical assessment of neoliberalism’s social impact over the past decades across the world is even possible. It suggests it is by empirically operationalizing neoliberalism in three distinct, yet potentially overlapping, ways that appear in the literature: first, as a broad set of economic institutions measured by economic freedom indexes; second, as the process of international trade liberalization (itself proxied by import shocks); and third, as shock-therapy type institutional reforms in (parts of) post-communist Europe. Synthesizing the findings of the existing vast research literature, the main conclusion of the article is that neoliberalism’s social impact has been more nuanced than suggested by prevailing discourse.