The Hazard Content of Cadmium, Lead, and Other Trace Elements in Some Medicinal Herbs and Their Water Infusions

Ababneh, Fuad A.

doi:10.1155/2017/6971916

Cited by 31 publications

(17 citation statements)

References 31 publications

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“…Our ndings for The range of cadmium in plants from the same sampling region was often broad with maximum and minimum concentrations approximately 12-fold in Manga sub-county and 11-fold in Borabu sub-county. Our ndings are similar to those reported for vegetation and indicated that the vegetation absorbed Cd from contaminated soil and water(Khattak and Khattak 2011;Khan 2013;Ting et al 2013;Zhu et al 2013;Filipiak-Szok et al 2015;Ababneh 2017).…”

supporting

confidence: 91%

Assessment of bio-availability of Cd, Pb, As and Tl via Gastric/Intestinal Digestion in Plants Collected From Different Kenyan Regions

Mogwasi

Getenga

Olale

et al. 2021

Preprint

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In this study, total and bio-available levels of cadmium (Cd), Lead (Pb), arsenic (As) and Thallium (Tl) in 19 Kenya plants from two study sites (Manga and Borabu) were evaluated. ICP-MS technique was used to determine total Cd, Pb, As and Tl contents, while ultra-filtration and physiological extraction tests evaluated bio-accessibility of these elements. The plants had low concentrations; Cd (0.27±0.02 and 0.26±0.02), As (0.32±0.02 and 0.48±0.04), Tl (0.07± 0.02 and 0.06±0.01) and Pb (1.23±0.11 and 1.16±0.10) mg/kg in Manga and Borabu sites. However, sequential ultra-filtration showed more than 70% high molecular weight species (>10 kDa) predominated with Pb, Cd and Tl. The physiological based tests showed Cd, Pb, As and Tl extracted enzymatically were significantly higher (0.45±0.11, 0.46±0.12, 0.37±0.10 and 0.81±0.19µg/g) than aquatically extracted (0.32±0.07, 0.34±0.11, 0.26±0.08 and 0.50±0.27) µg/g, (p<0.05). Low bio-accessibility levels of these elements in medicinal plants justifies their use therapeutically.

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supporting

confidence: 91%

Assessment of bio-availability of Cd, Pb, As and Tl via Gastric/Intestinal Digestion in Plants Collected From Different Kenyan Regions

Mogwasi

Getenga

Olale

et al. 2021

Preprint

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“…Sources of heavy metal contamination in herbal preparations could be linked to water used in irrigation, polluted soils, fertilizers and pesticides, industrial emissions, transportation, and harvesting and storage processes [3,4]. Metals such as zinc, iron, manganese, and copper are essential elements since they play an important role in biological systems and only become harmful at high concentrations, whereas mercury, lead, arsenic, chromium, and cadmium are nonessential elements as they are toxic, even at low concentration levels [5]. In general, the toxicity of heavy metals is due to the chemical reactivity of the ions with cellular structural proteins, enzymes, and membrane systems [6].…”

Section: Introductionmentioning

confidence: 99%

Health Risk Assessment and Determination of Some Heavy Metals in Commonly Consumed Traditional Herbal Preparations in Northeast Ethiopia

Meseret

Ketema

Kassahun

2020

Journal of Chemistry

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Background. Most traditional medicines were prepared from plant origins. These plants could be contaminated by heavy metals, pesticides, and/or toxins. Therefore, the aim of the present study was to determine the level of heavy metals such as lead (Pb), cadmium (Cd), chromium (Cr), and copper (Cu) in frequently used traditional herbal preparations sold in Northeast Ethiopia and to estimate their health risks associated with their daily intake. Methods. A total of 6 traditional herbal preparations were randomly collected from local herbal shops of Dessie and Kombolcha town, Northeast Ethiopia. The samples were prepared for analysis by wet digestion method using nitric acid and hydrochloric acid treatment. The accuracy of the method was analyzed by the spike recovery test. Determination of Pb, Cd, Cr, and Cu by microwave plasma atomic emission spectroscopy was made in herbal preparations traditionally used in Dessie and Kombolcha town, Northeast Ethiopia. By calculating estimated daily intake (EDI), hazard quotients (HQ), and Hazard Index (HI) of metals, the health risk associated with the consumption of the analyzed herbal preparations was also evaluated. Results. The levels of heavy metals were in the range of 3.0–3.92 mg/kg for Pb, 5.35–10.7 mg/kg for Cr, and 0.815–12.3 mg/kg for Cu. However, cadmium was not detected in any of the traditional herbal preparations. This study revealed that the level of Pb and Cu in all analyzed samples was within the WHO maximum permissible limit of 10 mg/kg and 40 mg/kg, respectively. The level of Cr in all traditional herbal preparations was beyond the WHO maximum permissible limit (2 mg/kg). From the health point of view, the HQ value of Cr for KD-03 and KD-04 is greater than 1, suggesting potential health risk. Furthermore, the HI value had revealed that the consumption of KD-02, KD-03, and KD-04 samples had the potential of posing health risks to consumers over long-term consumption of herbal preparations. Conclusion. This study showed that most of the metal concentration levels in the herbal products were within the WHO maximum permissible limits. However, all samples had Cr levels above the WHO maximum permissible limit. Based on the results of this study, there would be a noncarcinogenic health risk to the consumer associated with the consumption of some herbal preparations marketed in Northeast Ethiopia.

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“…Atualmente, têm ocorrido uma crescente preocupação no meio científico com a segurança e a qualidade (Zeiner & Cindrić, 2017) inerente à toxicidade de metais pesados em medicamentos à base de plantas, e isso é ilustrado pelos vários estudos realizados em países Asiáticos, como a China (Kong et al, 2020;Luo et al, 2021;Meng et al, 2021), Paquistão (Khan et al, 2021), Índia (Subramanian et al, 2012) e Filipinas (Solidum, 2014), em países Africanos, como Etiópia (Meseret; Ketema e Kassahun, 2020), Nigéria (Nkeiruka, Ebere & Obianime, 2012;Onyele & Anyanwu, 2018) e Argélia (Messaoudi & Begaa, 2018), em países Europeus, como Moldávia (Zinicovscaia et al, 2020) e Espanha (Martín-Domingo et al, 2017), em países do Oriente Médio, como Jordânia (Ababneh, 2017), Arábia Saudita (Ibrahim, 2014;Brima, 2017) e Irã (Zinsaz et al, 2015;Kohzadi et al, 2019) e em países da América do Sul, como o Brasil (Caldas & Machado, 2004;Leal et al, 2013;Silva, Francisconi & Gonçalves, 2016;Caldeirão et al, 2021;Souza et al, 2021;Tschinkel et al, 2020) e Peru (Zárate-Quiñones et al, 2021). Mas ainda há muito o que ser estudado (Zárate-Quiñones et al, 2021), considerando a importância dos oligoelementos para o metabolismo humano, bem como os riscos inerentes à saúde humana (Silva, Francisconi & Gonçalves, 2016).…”

Section: Metais Pesados Em Plantas Medicinais: Potencial Risco à Saúde Humanaunclassified

Plantas medicinais e fitoterápicos regulamentados no Brasil: risco de toxicidade por metais pesados

Alves

Melo

Gondim

et al. 2022

RSD

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Plantas medicinais acumulam metais pesados e metaloides em sua estrutura e em seus metabólitos secundários. Entretanto, quando a população consome essas plantas para o tratamento ou prevenção de diferentes doenças, sem o devido controle de qualidade e quantificação de metais pesados, pode estar se expondo a riscos de toxicidade devido a ingestão de elementos químicos que estão acima dos limites seguros para o consumo humano. Esse estudo de revisão narrativa teve por objetivo descrever as regulamentações relativas ao controle de metais pesados em plantas medicinais e fitoterápicos e destacar os riscos de metais pesados quantificados em plantas medicinais, com ênfase nas espécies compreendidas na Relação de Plantas Medicinais de Interesse ao Sistema Único de Saúde Brasileiro (RENISUS), que possuem Informações Sistematizadas. De acordo com os resultados obtidos, observamos que as Informações Sistematizadas da RENISUS não consideram as informações relativas a metais em plantas medicinais, mesmo havendo dados publicados. Nesse sentido, destacamos que é necessário o monitoramento periódico de metais pesados e a fiscalização de plantas medicinais sob a forma de drogas vegetais, com o intuito de mitigar a vulnerabilidade da população que consome esses produtos procurando benefícios à saúde com base na fitoterapia.

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The Hazard Content of Cadmium, Lead, and Other Trace Elements in Some Medicinal Herbs and Their Water Infusions

Cited by 31 publications

References 31 publications

Assessment of bio-availability of Cd, Pb, As and Tl via Gastric/Intestinal Digestion in Plants Collected From Different Kenyan Regions

Assessment of bio-availability of Cd, Pb, As and Tl via Gastric/Intestinal Digestion in Plants Collected From Different Kenyan Regions

Health Risk Assessment and Determination of Some Heavy Metals in Commonly Consumed Traditional Herbal Preparations in Northeast Ethiopia

Plantas medicinais e fitoterápicos regulamentados no Brasil: risco de toxicidade por metais pesados

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