2022 Help me understand this report
The HBV siRNA, ALG-125755, demonstrates a favourable nonclinical profile and significant and durable hepatitis B surface antigen reductions in the AAV-HBV mouse efficacy model
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“…essentially N-acetylgalactosamine; GalNac) (van den Berg et al, 2020;Dowdy and Levy, 2018;Hui et al, 2022;Springer and Dowdy, 2018). There are currently 5 RNAi (JNJ-3989, VIR-2218, AB-729, ALG-125755, RG6346), evaluated in monotherapies and/or combination in clinical trials (Fitzgerald et al, 2022;J. Hepatol.…”
Section: Strategies To Directly or Indirectly Improve Hbsag Loss/sero...mentioning
confidence: 99%
“…essentially N-acetylgalactosamine; GalNac) (van den Berg et al, 2020;Dowdy and Levy, 2018;Hui et al, 2022;Springer and Dowdy, 2018). There are currently 5 RNAi (JNJ-3989, VIR-2218, AB-729, ALG-125755, RG6346), evaluated in monotherapies and/or combination in clinical trials (Fitzgerald et al, 2022;J. Hepatol.…”
Section: Strategies To Directly or Indirectly Improve Hbsag Loss/sero...mentioning
confidence: 99%
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